A team of scientists conducting diabetes research at the Fox Chase Research Center in Philadelphia, PA discovered the presence of a toxic substance , 3-deoxyglucosone (3DG), in skin. These scientists then uncovered the link between 3DG, skin aging, collagen depletion, and loss of skin elasticity. Further scientific research led the team to develop Supplamine, a powerful new formulation for addressing the effects of glycation and oxidative stress on skin. Clinical tests demonstrate that Supplamine inhibits the harmful effects of 3DG, reduces the appearance of fine lines and wrinkles, increases moisture and skin glow, and improves overall skin texture, firmness and smoothness. Noticeable results occur in just four weeks or less! MEG 21 Age Defying Hand Treatment is far beyond a good moisturizer. This unique formulation powered by Supplamine revitalizes hands and reduces the appearance of aging by counteracting the effects of glycation and oxidative stress on skin. Supplamine contains an intensive combination of amino acids, anti-inflammatory agents, and anti-oxidants that target fine lines, wrinkles, dryness and uneven skin tones.
Key Ingredients
Free U.S. Shipping. Period. View Our Shipping Policy
Return Policy: This product is non-returnable
Availability: This product is no longer available.
Submit your question about this product to our talented team of Customer Care Representatives, and we'll get back to you as soon as possible!
lss
Verified Purchase
Not wowed by this hand cream. I have a feeling no matter what anyone says, all hand creams are probably pretty much the same.
bear
Verified Purchase
Love this and it has no fragrance, and it seems to be a great anti-aging product so far!
LovelySkin Customer
Verified Purchase
Confession: I was skeptical about this product, but the reviews convinced me to try it, and I'm so glad I did! This MEG 21 treatment works wonders for skin suppleness and wrinkling. My hands look and feel younger, smoother, more emoliated, and far better hydrated. I'm a great Before - I have 65-year-old hands that spent a lot of time in the high desert, along with Raynaud's Syndrome - which reduces circulation quality on the hands - so my hands were showing their years. But not any more! I now pair this MEG 21 with a hand cream from a different brand from the fine folks here at LovelySkin and apply liberally. Don't like to get caught without it! MEG 21 is a total game-changer.
LovelySkin Customer
Verified Purchase
Excellent hand treatment -- I use Meg21 on my face as well. I use it twice a day, just on the top of my hands.
LovelySkin Customer
Verified Purchase
I was looking for a product for my hands and arms. This product is great and I have activated a auto replenishment on it so I can be sure to have it on hand. The texture of my skin improved very quickly and some hand bruising I was getting has subsided since using this product.
susanb26
Verified Purchase
…that’s not saying much. Perhaps my 65-year-old hands are beyond help. I have been using this almost every night before bed for almost 6 months. I like the way my hands look when I put it on, but it’s not super-moisturizing and there seem to be no cumulative effects. I just keep buying it coz I haven’t yet found anything better.
Mella
Verified Purchase
This is fairly moisturizing. Haven’t noticed a huge difference in my hands, however. Maybe after a bit more time it will get better.
blc59
Verified Purchase
I have only been using for a few weeks but it appears that the back of my hands look and feel smother as well are a little less spotted. I am looking forward to seeing how they look after a few months of use.
Debann
Verified Purchase
I think I need to use it a little longer for the best results but so far I am loving how it makes my hands look and feel. I would recommend it to anyone looking to improve the appearance of their hands!
Anonmously
Verified Purchase
1st time user and after 3 weeks, I have a softer feel than any other lotion has provided - can't wait to see the difference at 6 months:)
LovelySkin Customer
Verified Purchase
I purchased to soothe my very dry aging hands and this hand treatment delivers results. I apply twice a day, in the am after I'm done applying my skincare and evening before bed. The Meg21 treatment absorbs fast and leaves no greasy film. To soon to see results of faded dark pigments but after use, the tops of my palms look firmer. I also use on rough dry elbows.
LovelySkin Customer
Verified Purchase
This lotion takes patience but after using it every night for a month, I definitely see improvement in the look and feel of the skin on my hands. Reasonably priced. Recommend.
Radu
Verified Purchase
I'm 43 with fair skin. I take great care of my face but have neglected my hands. The last few years I've noticed my hands aging. I've been using this lotion for the tops of my hands only for about a week. I am seriously impressed with the difference! Crepy skin is slightly reduced but there is a significant decrease in hyperpigmentation/age spots. I will never be without this product again! And I'm going to purchase driving gloves too!
LovelySkin Customer
Verified Purchase
I have been using Meg 21 morning and Evening for about three weeks now. I have very dry hands which cause them to look older than they should. I love the feel of this lotion. Instantly my hands look smoother and younger. It doesn't really have a smell and doesn't leave an oily feel. I plan to purchase again!!
LovelySkin Customer
Verified Purchase
Pro: I have noticed a reduction in my developing age spots. My hands do appear more even in appearance. However, I do not find this lotion to be particularly moisturizing. Given the small size and large cost, not sure it’s worth it and probably will look for a different product.
Tramany
Verified Purchase
This hand lotion is amazing! My hands have been so dry especially now with washing my hands extra times due to the pandemic. I have tried so many other lotions and was never satisfied but this lotion is a WINNER!
MomofIrishtwins
Verified Purchase
I’ve been using this product for a little while and it really does work. I was initially sent a sample and loved it so much that I decided to buy a full sized bottle. The backs of my hands, which were starting to look like crepe paper, are now smooth and hydrated. It’s non greasy and penetrates into my skin rather quickly. I wash my hands a lot and apply this throughout the day. I’m so thankful that my hands are looking much better.
Melissao
Verified Purchase
If I had to say one thing that really shows a person's age- it would be their hands. I think they are often neglected. I received a sample of this and I ordered within a week of trying it. It smooths and plumps effortlessly. It is not heavy or sticky
Lada
Verified Purchase
MEG 21 Top of the Hands HAND CREAM IS BY FAR THE BEST HAND CREAM I HAVE EVER USED! I will never again go searching for something that works because I found it! I am thrilled with the results and so quickly. HIGHLY RECOMMEND!
LovelySkin Customer
Verified Purchase
My hands are aging fast with all of the hand washing and gardening I'm doing this year. . . I liked how a sample of this made my hands feel. I notice the most improvement in appearance right after using it. Definitely makes them look younger, more luminous. Not sure it really has long term results, but I'm really putting my hands through a lot, so I don't know if I can really expect anything topical to turn back time. I'm 44.
| Mon - Fri | 9 - 5 p.m. CT |
| Sat (chat only) | 9 - 3 p.m. CT |
| Sun / Holidays | Closed |
| Call or Text: | 402-697-1100 |
20% Off Most Brands During Our Customer Appreciation Sale + Free $6 OLAPLEX No. 3 Hair Perfector Gift! 
