SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator

1.7 fl oz

4.6 View 278 reviews

| HSA/FSA Eligible LMN Required

$192.00

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Highlights

Provides immediate and long-term hydration
Boosts hyaluronic acid production

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Product Overview

SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator restores hyaluronic acid production deep in skin for a plump, dewy complexion.

Featuring five forms of hyaluronic acid, plus a Hydra Collagen Complex for immediate hydration, this lightweight cream to water serum restores endogenous hyaluronic acid production deep within the skin's layer to provide immediate results that last 48 hours. Potent and powerful, this serum improves hydration, reinforces the skin barrier and boosts skin's water-holding capacity.

Clinical Results:

Patients reported their skin looked approximately 3 years younger by week 12
93% reported it made their skin appear more healthy and dewy in 2 weeks
85% experienced visibly pumper skin in 12 weeks
97% agreed this product improved skin quality at 12 weeks
100% experienced confidence in their skin by week 12

Key Features:

HA5®, featuring five proprietary forms of hyaluronic acid, releases different molecular weights and types of hyaluronic acid (2x the previous HA5 formula) to instantly smooth the appearance of fine lines and wrinkles on the skin's surface
A Hydra Collagen Complex, derived from vegan collagen, provides optimal immediate hydration
Proprietary Advanced VITISENSCE® Technology provides long-term hydration and targets existing collagens within the skin to boost hydration naturally
Contains 100% vegan collagen complex; not a certified animal-derived collagen product

Highlights

Provides immediate and long-term hydration
Boosts hyaluronic acid production
Made with Vegan Collagen

Ingredients

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Questions & Answers (7)

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Product Specifications

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About the Brand

Featured In

Customer Reviews (278)

Overall Rating

4.6

Based on 278 reviews

Review Summary

5 Stars

231

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278 Reviews

FlygirlD

from Arkansas

Normal Skin

Verified Purchase

April 10, 2026

Nice moisturizer

Love the moisturizer effect of this product. I put it on top of day and nighttime serums or treatments. Have been using product for 3 week. Seem to “ soften” fine lines. The moisture seems to last all day on me, but not heavy or oily. Might consider keeping this one in my skincare routine. No break outs or irritation.

1 person found this helpful

Charlies4th

from Indiana

Age Group: 60-69

Wavy Hair

Normal Skin

April 08, 2026

Makes my Face look plumper

Love this product. I put this on as my last item in my skincare routine and it makes your skin feel so good. It makes my skin plumper and since I don't use a moisturizer this works at hydrating my skin very well. Goes great with the skin line ZO. It doesn't interact and ball up like other products do.

0 people found this helpful

Candygirl21

from Virginia

Age Group: 50-59

Verified Purchase

April 06, 2026

Amazing

This is the best product and a must add to your daily use. My skin has never looked so good! Been using for a year now. It’s a must use!

1 person found this helpful

Mine

from Georgia

Verified Purchase

March 31, 2026

Skinmedica HA5 Hydra Collagen Replenish + Restore Hyrator

This product is one of my favorites. It hydrates my skin and keeps it younger looking.

0 people found this helpful

Jog1

from Maine

Age Group: 70-79

Combination Skin

Verified Purchase

March 30, 2026

Luxury product

This serum goes on like a layer of silk. It’s so cold in Maine during the winter and I had little dry skin flakes all over my face. Within three days they were all gone and they’ve stayed gone. Love this product.

2 people found this helpful

ImNotOld

from Florida

Age Group: 60-69

Coily, Dry Hair

Dry Skin

Verified Purchase

March 29, 2026

Great Hydrator

I have used Skin Medica hyaluronic acid for a long time and love the new formulation. It dries beautifully- Not sticky like some other brands. It is step one of my skin care routine for day and night

1 person found this helpful

LovelySkin Customer

from Georgia

Age Group: 60-69

Mature Skin

Verified Purchase

March 24, 2026

Made a real difference

I've been trying lots of different products to address what I think is just a hydration issue. At any rate, nothing has made much of a change until this. After just a few days my skin looked fresher and plumper. I had used this years ago and I'm happy to have found it again!

1 person found this helpful

TexasTingle

from Texas

Age Group: 60-69

Mature Skin

Verified Purchase

March 22, 2026

Fantastic Product

This is an amazing product and has helped my fine lines and wrinkles become much less noticeable. Goes on like silk, absorbs quickly, and since you only use a small amount, lasts quite awhile. Though it’s costly, you can’t feel and see it’s a high end product.

1 person found this helpful

Momhere

from Florida

Age Group: 80+

Verified Purchase

March 20, 2026

Great product

Keeps skin moist but not greasy. I use every morning and night. Wrinkles have softened too! Yea!

1 person found this helpful

Mmp2627

Age Group: 70-79

Mature Skin

Verified Purchase

March 19, 2026

Mature skin

Helpful. I have somewhat fragile skin. No reaction. That is something for me. I use Skin Ceuticals Triple Lipid as a moisturizer

1 person found this helpful

LovelySkin Customer

from Massachusetts

Verified Purchase

March 19, 2026

HA5

Fantastic product that not only nourishes but deeply hydrates. This is my go to product to apply immediately following infrared mask treatments

0 people found this helpful

LovelySkin Customer

Age Group: 70-79

Mature Skin

Verified Purchase

March 17, 2026

Love this

This goes on so silky and easily, no rubbing in or tugging at your skin! It hydrates, plumps a bit and wears well under makeup.

0 people found this helpful

NP2

Age Group: 70-79

Mature Skin

Verified Purchase

March 16, 2026

Great hydration

I love this moisturizer. It makes my skin clean, bright and it glows. Restores hydration and it’s balanced and healthy. It helps to smooth out fine lines and removes any dry patches. My skin looks years younger after month of use

1 person found this helpful

GANurse

from Georgia

Age Group: 50-59

Verified Purchase

March 14, 2026

Silky Smooth

I love how smooth and silky the product feels on my skin. Non-irritating on my neck and decollete.

0 people found this helpful

MAS01254

Verified Purchase

March 13, 2026

Love this product

Use it day and night and want a difference it makes!

0 people found this helpful

LovelySkin Customer

from Massachusetts

Verified Purchase

March 12, 2026

One of my favorite serums

Love this serum. However the new formula broke me out and I’m devastated.

0 people found this helpful

LovelySkin Customer

from North Carolina

Age Group: 60-69

Wavy, Dry Hair

Dry Skin

Verified Purchase

March 11, 2026

Relief for dry skin

I have mature dry skin. The Skin Medica line- specifically the HA5 Hydra really has helped combat my dry, tight- feeling skin this winter. I mix it in my moisturizer for best results for me.

1 person found this helpful

Crazysadie

from New York

Verified Purchase

March 10, 2026

Very Hydrating

I really like using this product, but wish that it wasn't so expensive. It hydrates and does the job that it's suppose to do.

2 people found this helpful

LovelySkin Customer

Verified Purchase

March 10, 2026

SkinMedica HA5 Hydra Collegen Replenish

This is a great product for skin hydration, rejuvination. It goes on smoothly and dries quickly. I use it every morning as my first product after cleansing my face. Would definitely recommend it.

0 people found this helpful

Cathi

from Florida

Age Group: 70-79

Verified Purchase

March 09, 2026

Absolutely perfect for me!

I’m 71 and have been using HA5 for 2 years and use it morning and night. Immediately adsorbs, moisturizer and then foundation with SPF!

1 person found this helpful

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SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator

Product Overview

SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator restores hyaluronic acid production deep in skin for a plump, dewy complexion.

Highlights

Ingredients

Directions

Shipping & Returns

Questions & Answers (7)

Product Specifications

Special Offers

About the Brand

Featured In

Customer Reviews (278)

Overall Rating

Review Summary

Write a Review

Nice moisturizer

Makes my Face look plumper

Amazing

Skinmedica HA5 Hydra Collagen Replenish + Restore Hyrator

Luxury product

Great Hydrator

Made a real difference

Fantastic Product

Great product

Mature skin

HA5

Love this

Great hydration

Silky Smooth

Love this product

One of my favorite serums

Relief for dry skin

Very Hydrating

SkinMedica HA5 Hydra Collegen Replenish

Absolutely perfect for me!

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