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SkinMedica TNS® Advanced+ Serum

1.0 oz
| HSA/FSA Eligible LMN Required
$295.00

Special Offer: 10% off use code SKMD10

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Highlights
  • Fragrance-free
  • Boosts collagen and elastin production
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Product Overview

SkinMedica TNS® Advanced+ Serum offers the classic formula, now supercharged.

This SkinMedica serum builds upon the legendary results of its predecessor for powerful anti-aging. Every piece of the TNS Essential serum, from the peptides to the growth factors has been rethought and amplified. Because of this, it’s even better at softening wrinkles, diminishing dark spots and addressing other signs of aging.

Formulated with TNS®-MR, the next-generation growth factor blend, this serum acts on multiple levels of the skin to achieve the best results. Additionally, Renessensce (RSC) Advanced, a highly active blend of botanicals, peptides and marine extracts, supports skin renewal for plumper, more youthful skin, delivering results in as little as two weeks.

Clinical Results:

  • Smooths visible coarse wrinkles and fine lines; with results starting as early as 2 weeks
  • Clinically proven to address sagging skin at week 8
  • Progressive results measured over 24 weeks

Key Features:

  • New Innovative 2 Tripeptide Complex visibly firms and smooths fine lines and wrinkles
  • Potent blend of Spanish Marine extract and Green Microalgae builds collagen and supports skin's repair process
  • Provides antioxidants for improved defense against environmental stress
  • Visibily lifts sagging skin while improving skin tone and texture
  • Fragrance-free and paraben-free

Highlights

  • Fragrance-free
  • Boosts collagen and elastin production
  • Contains growth factors

Ingredients

Directions

Shipping & Returns

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Special Shipping Requirements: ORM-D Class
ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! .

Questions & Answers (6)

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Product Specifications

About the Brand

Customer Reviews (1952)

Overall Rating

4.6
Based on 1952 reviews

Review Summary

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1952 Reviews

Profile picture of LazyL.

LazyL

from Georgia

Age Group: 60-69

Straight, Dry Hair

Mature Skin

Verified Purchase

April 30, 2026

Great Product

I've been using this product for over one month and have noticed such a great improvement with my skin. I am in my late 60's, my skin is dry and I have not had any facial fillers so I do have wrinkles from aging. Since using this serum I have noticed less wrinkles, my dryness especially around the mouth area is not as pronounced and overall appearance on my face looks so much better. I am also using this on my neck and it has made such an improvement that it's not so dry and tight feeling. I do use this morning and evening. I like that this product doesn't have a scent too.

0 people found this helpful

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nguerlain

from Oregon

Age Group: 40-49

Wavy hair, Dry/flaky scalp

Dry Skin

Verified Purchase

April 28, 2026

Great Serum

I also rotate in the TNS Recovery Treatment. They are both spendy but I notice a difference in my skin fairly quickly and I already have great skin.

0 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 50-59

Wavy hair, Damage & split ends

Normal Skin

Verified Purchase

April 27, 2026

Not Impressed

I have been using it for 7 weeks and haven't noticed any improvements in my skin, not even the texture. When I run out of this bottle, I won't be buying another one.

0 people found this helpful

Profile picture of Guesswho1225.

Guesswho1225

from Florida

Age Group: 70-79

Curly hair, Dry/flaky scalp

Combination Skin

Verified Purchase

April 26, 2026

INFERIOR PACKAGING FOR EXCELLENT PRODUCT

First time ordering and most likely will find a suitable substitute, as the one side of the dispensing product has failed to perform, making me not be the benefit of the full product. Skin Medica really missed the boat on this product. Now I only have 1 side to dispense from. More than likely will search for an equal product with better dispensing.

0 people found this helpful

Profile picture of Suzyg.

Suzyg

from New York

Age Group: 60-69

Wavy, Color treated hair

Mature Skin

Verified Purchase

April 26, 2026

Definitely recommend

Expensive but the best with excellent results I highly recommend spending the extra money

0 people found this helpful

Profile picture of Pattiandmom.

Pattiandmom

Wavy, Color treated hair

Normal Skin

Verified Purchase

April 14, 2026

Improved packaging

Been using TNS since it's beginning, it's a valuable product, especially for mature skin .In the past, I had problems with the dispenser so far it seems to be improved with the new packaging. It dispenses better, more evenly and more consistently. A must have night time basic . Use it -give your skin the edge You'll be thankful

3 people found this helpful

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LovelySkin Customer

from California

Age Group: 70-79

Wavy Hair

Dry Skin

Verified Purchase

April 13, 2026

Amazing TNS

Been using this product for years. It’s the best anti-aging cream out there. I can tell my dry skin is nourished and glowing. And the new way of dispensing is great!

1 person found this helpful

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LovelySkin Customer

from Arizona

Verified Purchase

April 13, 2026

Game changer.

I love this product–silky going on, not sticky. I use in my evening routine and and visible results in a couple weeks. Absolute game changer. Only con is the air pump - was temperamental when traveling.

1 person found this helpful

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LovelySkin Customer

from Michigan

Wavy Hair

Verified Purchase

April 10, 2026

My skin never looked Better

I am a 77 year-old woman and I have been told I have beautiful skin. Thanks to skin medica serum. I’m not gonna lie. I do have wrinkles however by using this, it has definitely softened them and I love the feel of my skin. This is part of my daily ritual.

1 person found this helpful

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LovelySkin Customer

from Washington

Verified Purchase

April 06, 2026

Skin Medica TNS Advanced Serum

I have been using this product for nearly two years. I am 68 yrs old with sensitive aging skin. My skin does very well with this product. No irritation! I see visible results with my skin looking smooth, less wrinkles and redness.

0 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 60-69

Mature Skin

Verified Purchase

April 05, 2026

Totally Awesome Serum

Buy this product NOW. Within a day, my 63 year old skin looked smoother, more hydrated and brighter. In fact, after using for about one week, my sister looked at me and said that my skin looked amazing and asked what I was using. I highly recommend it and will definitely purchase again.

0 people found this helpful

Profile picture of HollyS1.

HollyS1

from Texas

Age Group: 40-49

Dry Skin

Verified Purchase

April 05, 2026

Not happy with the new pump!

I’m 49 and have used TNS serum many years but my last 2 bottles the peptide side ran out way before the other and that makes the product not effective. I’m going to need to look at buying other products because I can’t afford for my product to run out like that.

7 people found this helpful

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LovelySkin Customer

from Arizona

Age Group: 60-69

Dry Skin

Verified Purchase

April 02, 2026

One Side Ran Out Before the Other!

I love the TNS Advanced+Serum. I've been using it for about a year now. Never had an issue with the two sides regarding distribution but this bottle (which is the new version) has been completely empty with the clear Serum for a week now! This is way too expensive for this to be happening.

11 people found this helpful

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LovelySkin Customer

from Virginia

Verified Purchase

April 01, 2026

New packaging, same wonderful results!

Have been using this serum for many years with wonderful results. Pricey, but worth it!

2 people found this helpful

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Mine

from Georgia

Verified Purchase

March 31, 2026

Absolutely the best product I have used!

I am so happy with this product! It has made a drastic change to my skin.

4 people found this helpful

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LovelySkin Customer

from Texas

Verified Purchase

March 27, 2026

Amazing

Transformed my skin in 2weeks

3 people found this helpful

Profile picture of LaurieLaurie.

LaurieLaurie

from Michigan

Age Group: 70-79

Wavy Hair

Mature Skin

Verified Purchase

March 25, 2026

So excited!

Im 70. I just ordered the TNS Advance and cant wait to get started. I did the camera skin analysis and I'll come back and leave a 60 day review.

3 people found this helpful

Profile picture of Minsk.

Minsk

from Texas

Verified Purchase

March 23, 2026

Good product however

This is a great product, but very pricey for the amount. The new packaging works a bit better but runs out much sooner than the last one. I hate not knowing when your last pump is. Especially when you are on a trip. No way to know how much is left , when to reorder. No way to get the last bit out. And at this price point, you certainly want every last drop. Bottles are impenetrable.

16 people found this helpful

Profile picture of Kwittmayer.

Kwittmayer

from Oregon

Age Group: 40-49

Normal Skin

Verified Purchase

March 23, 2026

Worth the Investment

Finally decided to invest in better skin care and this product has not disappointed. I am in my mid 40s and have decided to make sure that I am using the right product that will help me long-term. My fine lines and wrinkles have definitely improved and the new packaging works great. I’ll be using this as a part of my skin care routine moving forward!

2 people found this helpful

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LovelySkin Customer

from Massachusetts

Age Group: 50-59

Verified Purchase

March 21, 2026

Long time user

I have used this product for over 10 years. I can confidently say that it is one of the reasons my skin is still very firm and youthful.

1 person found this helpful

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