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SkinMedica TNS® Advanced+ Serum

1.0 oz
| HSA|FSA Eligible LMN Required
$221.25
$295.00 25% Off
Highlights
  • Fragrance-free
  • Boosts collagen and elastin production
  • Contains growth factors
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Product Overview

SkinMedica TNS® Advanced+ Serum offers the classic formula, now supercharged.

This SkinMedica serum builds upon the legendary results of its predecessor for powerful anti-aging. Every piece of the TNS Essential serum, from the peptides to the growth factors has been rethought and amplified. Because of this, it’s even better at softening wrinkles, diminishing dark spots and addressing other signs of aging.

Formulated with TNS®-MR, the next-generation growth factor blend, this serum acts on multiple levels of the skin to achieve the best results. Additionally, Renessensce (RSC) Advanced, a highly active blend of botanicals, peptides and marine extracts, supports skin renewal for plumper, more youthful skin, delivering results in as little as two weeks.

Clinical Results:

  • Smooths visible coarse wrinkles and fine lines; with results starting as early as 2 weeks
  • Clinically proven to address sagging skin at week 8
  • Progressive results measured over 24 weeks

Key Features:

  • New Innovative 2 Tripeptide Complex visibly firms and smooths fine lines and wrinkles
  • Potent blend of Spanish Marine extract and Green Microalgae builds collagen and supports skin's repair process
  • Provides antioxidants for improved defense against environmental stress
  • Visibily lifts sagging skin while improving skin tone and texture
  • Fragrance-free and paraben-free

Highlights

  • Fragrance-free
  • Boosts collagen and elastin production
  • Contains growth factors

Ingredients

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Questions & Answers (6)

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Product Specifications

About the Brand

Customer Reviews (1879)

Overall Rating

4.6
Based on 1879 reviews

Review Summary

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1879 Reviews

Profile picture of buffaloprince.

buffaloprince

from Minnesota

Verified Purchase

December 03, 2025

TNS

I guess it works? I don’t notice big differences in my skin so for the price not sure I’ll buy again

0 people found this helpful

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LovelySkin Customer

from Minnesota

Age Group: 40-49

Verified Purchase

December 01, 2025

Overall

I’ve been using this product for over a decade. It is an amazing product that I always return to. I love how it improves my skin. So I am still giving this a 5 star review based on that. However, I’ve now seen three different packaging designs over the years and I must say that the newest packaging design is the worst by far. The pumps are too far apart. You have to first try to pump product evenly into your palm to then mix together and then apply to your face. It’s messy, clunky and easy to accidentally pump too much or too little of each serum creating an uneven mixture. I do not understand how SkinMedica R&D thought this would be a better packaging solution. Honestly this poorly designed packaging could force me to move to a different brand. At least I will know the product I’m putting on my face is consistent every time.

1 person found this helpful

Profile picture of Jellyka.

Jellyka

Age Group: 50-59

Straight Hair

Normal Skin

Verified Purchase

December 01, 2025

I like it so far

I like this so far. I can’t really say if it actually has changed my skin because in all fairness, I buy it off and on and I’m not consistent with it because it is pricey. I’ve read that this is more like the cherry on top once you are consistent with sunscreen, vitamin C, and retin A. I just purchased again because I plan on being consistent this time. If after this bottle I don’t see significant change in my skin then I will just stick to the basics and a couple of other skin care items that I think make a difference like peptides, glycolic acid and a good lipid containing moisturizer to top it all off. If any young women are reading this (Denise) if you can only put on one thing daily, make it sunscreen. It will be the best investment and later you won’t need to reverse that sun damage. Sunscreen, vitamin C, Retin A once you’re doing that consistently then you can add this cherry on top if you want to splurge. That’s my advice to all you young pretty girls..

1 person found this helpful

Profile picture of Gigi88.

Gigi88

from North Carolina

Age Group: 70-79

Straight hair, Damage & split ends

Mature Skin

Verified Purchase

November 29, 2025

My #1 Serum

I think most of us look for the products that are easy to use and produce noticeable results. This serum is so good it is hard to replace...I haven't purchased another face serum for years because SkinMedica TNS moisturizes, firms, evens my skin, and fades dark spots. People that I haven't seen for years ask me if I had work done. If I could only have one product for my skin, it would be this one. Still searching for my #1 eye product! It's expensive, but totally worth it!

0 people found this helpful

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LovelySkin Customer

from Tennessee

Verified Purchase

November 27, 2025

TNS Serum

I started using this and love the way my skin feels and glows. It just gets better and better! Lots of compliments and how glowy my skin looks

0 people found this helpful

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LovelySkin Customer

from Texas

Age Group: 60-69

Straight, Color treated hair

Mature Skin

Verified Purchase

November 26, 2025

Love this product

I love the way this makes my face feel. I am retired so was up in the air as to whether to spend the money or not. Well worth the investment.

3 people found this helpful

Profile picture of JillF123.

JillF123

from Alabama

Age Group: 40-49

Normal Skin

Verified Purchase

November 25, 2025

It’s good…

…but it’s not perfect and for this price I think it should be. It pills underneath my sunscreen/makeup so I have stopped using it as a daytime serum. I also don’t love the pump; it doesn’t work well and I think it wastes product. It seems like they updated the pump right after I purchased mine so maybe that’s resolved. I do like how my skin has been looking; I feel like my skin is glowy/soft and my discoloration looks a little less noticeable. When the pump doesn’t work correctly and I wind up with extra serum I have been putting it on the tops of my hands and I think even that little bit has my hands looking better. I don’t know yet if I will purchase it again, it was on sale so I wanted to give it a try.

3 people found this helpful

Profile picture of Meme.

Meme

from California

Age Group: 50-59

Dry Skin

Verified Purchase

November 19, 2025

Liquid gold

I love this stuff. It really does everything it claims. I use it once a day and saw noticeable difference in one month of use. I have been using this for a few months now. The price seems like you are paying for gold but it is, liquid gold. Can't live without it now!

0 people found this helpful

Profile picture of LindaJ.

LindaJ

from California

Verified Purchase

November 18, 2025

It's really good!

I have used this product for years and enjoy the results!

0 people found this helpful

Profile picture of DSamIam.

DSamIam

Age Group: 60-69

Mature Skin

Verified Purchase

November 15, 2025

Morning/Nightly Addiction

I absolutely love the Skinmedica TNS!! It is the first thing I put on my face in the morning & the last thing at night. My skin looks smoother since I started using it about a year ago. Now I auto-ship because I cannot do without it.

0 people found this helpful

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LovelySkin Customer

Age Group: 40-49

Verified Purchase

November 14, 2025

Holy Grail

I started using this 2-3 years ago, buying when SkinMedica products offered a discount due to $$$. But a small amount of product goes a long way. I can see deceased signs of aging and improved skin texture on my face and neck with continued use. If I splurge on a beauty product, this is the one!

0 people found this helpful

Profile picture of KatieMC.

KatieMC

from California

Age Group: 40-49

Straight Hair

Normal Skin

Verified Purchase

November 13, 2025

The holy grail

I should have started this earlier but I am now addicted. The way it makes you skin feel and the glow you get from it is none other. Highly recommend - price is high but worth every penny!

0 people found this helpful

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LovelySkin Customer

from Illinois

Age Group: 70-79

Wavy, Dry Hair

Combination Skin

Verified Purchase

November 13, 2025

TNS ADVANCE + SERUM

I have been using TNS for over 2 years. I am in my 70’s and have used many facial serums. Since using TNS I have seen great improvement in fine lines and wrinkles on all areas of my face. Overall I am more than pleased with the results of this product.

1 person found this helpful

Profile picture of Sbeny.

Sbeny

from Idaho

Verified Purchase

November 12, 2025

Great Product

I have been using SkinMedica TNS Advanced+ Serum for almost 2 years now. I have really noticed a difference in my skin texture and tone. Love it!

1 person found this helpful

Profile picture of LauraMac.

LauraMac

from California

Age Group: 30-39

Combination Skin

Verified Purchase

November 11, 2025

You can see the results!

This was recommended by my dermatologist, and I’ve been using it for about 2 years now. It does not irritate my sensitive, acne prone skin, and I can see the results.

0 people found this helpful

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LovelySkin Customer

from Indiana

Age Group: 50-59

Straight, Color treated hair

Dry Skin

Verified Purchase

November 11, 2025

My Beauty Secret

I have been using this religiously for years. I just turned 51 and get compliments on my skin often. I got for my 77 year old mother and she says it makes a difference and is worth every penny!!!

0 people found this helpful

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LovelySkin Customer

from California

Verified Purchase

November 04, 2025

GOAT

Yes, I expensive but works so well. I think I’m on maybe my 10th bottle and everyone always says I look younger than my age

0 people found this helpful

Profile picture of Mic53.

Mic53

Age Group: 50-59

Verified Purchase

October 30, 2025

TNS

I’ve been using TNS Advanced+ Serum for a while now, and the results are incredible. My skin feels noticeably smoother, firmer, and more radiant. The texture is lightweight and absorbs quickly, leaving my face feeling refreshed and hydrated without any greasy residue. I’ve also noticed that my fine lines appear softer, and my overall complexion looks more even and youthful. It truly gives my skin that “glow from within” look. What I love most is how consistent the results are — my skin keeps improving week after week. It feels like a professional-grade treatment in a bottle.

0 people found this helpful

Profile picture of BKF.

BKF

from Georgia

Age Group: 60-69

Curly, Dry Hair

Mature Skin

Verified Purchase

October 28, 2025

TNS Advanced Serum

This was recommended to me by an esthetician. I have only been using for a couple of weeks. So far my skin does feel smooth but I feel I haven't used long enough to see much of a difference as far as wrinkles are concerned. I have mature, post menopausal dry/dehydrated skin. Hopefully with time it will improve. I do store this product upside down as recommended which helps when dispersing as it has two formulas within one bottle. This helps with even distribution of the product.

2 people found this helpful

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LovelySkin Customer

from Texas

Age Group: 40-49

Verified Purchase

October 28, 2025

Can’t live without it!

I’ve been using this for years! My skin is not the same when I stop using it! It truly makes your skin glow and appear several years younger! I get compliments on my skin even by estheticians and I promise this is one of the key factors to beautiful skin!

0 people found this helpful

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