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SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator with Vegan Collagen Duo

 
| HSA/FSA Eligible LMN Required
$384.00

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Highlights
  • Deeply moisturizing
  • Provides immediate and long-term hydration
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Product Overview

SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator with Vegan Collagen Duo restores hyaluronic acid production for a plump, dewy complexion.

Featuring five forms of hyaluronic acid, plus a Hydra Collagen Complex for immediate hydration, this lightweight cream-to-water serum restores endogenous hyaluronic acid production deep within the skin's layers to provide immediate results that last 48 hours. Potent and powerful, this serum improves hydration, reinforces the skin barrier and boosts skin's water-holding capacity.

Set Includes:

  • HA5 Hydra Collagen Replenish + Restore Hydrator (2.0 oz x 2)

Clinical Results:

  • Patients reported their skin looked approximately 3 years younger by week 12
  • 93% reported it made their skin appear more healthy and dewy in 2 weeks
  • 85% experienced visibly pumper skin in 12 weeks
  • 97% agreed this product improved skin quality at 12 weeks
  • 100% experienced confidence in their skin by week 12

Key Features:

  • HA5®, featuring five proprietary forms of hyaluronic acid, releases different molecular weights and types of hyaluronic acid (2x the previous HA5® formula) to instantly smooth the appearance of fine lines and wrinkles on the skin's surface
  • A Hydra Collagen Complex, derived from vegan collagen, provides optimal immediate hydration
  • Proprietary Advanced VITISENSCE® Technology provides long-term hydration and targets existing collagens within the skin to boost hydration naturally

Highlights

  • Deeply moisturizing
  • Provides immediate and long-term hydration
  • Boosts hyaluronic acid production

Ingredients

Directions

Shipping & Returns

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Return Policy: This product is non-returnable

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Special Shipping Requirements: ORM-D Class
ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! .

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Product Specifications

About the Brand

Customer Reviews (271)

Overall Rating

4.6
Based on 271 reviews

Review Summary

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271 Reviews

Profile picture of Momhere.

Momhere

from Florida

Age Group: 80+

Verified Purchase

March 20, 2026

Great product

Keeps skin moist but not greasy. I use every morning and night. Wrinkles have softened too! Yea!

0 people found this helpful

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Mmp2627

Age Group: 70-79

Mature Skin

Verified Purchase

March 19, 2026

Mature skin

Helpful. I have somewhat fragile skin. No reaction. That is something for me. I use Skin Ceuticals Triple Lipid as a moisturizer

0 people found this helpful

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LovelySkin Customer

from Massachusetts

Verified Purchase

March 19, 2026

HA5

Fantastic product that not only nourishes but deeply hydrates. This is my go to product to apply immediately following infrared mask treatments

0 people found this helpful

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LovelySkin Customer

Age Group: 70-79

Mature Skin

Verified Purchase

March 17, 2026

Love this

This goes on so silky and easily, no rubbing in or tugging at your skin! It hydrates, plumps a bit and wears well under makeup.

0 people found this helpful

Profile picture of NP2.

NP2

Age Group: 70-79

Mature Skin

Verified Purchase

March 16, 2026

Great hydration

I love this moisturizer. It makes my skin clean, bright and it glows. Restores hydration and it’s balanced and healthy. It helps to smooth out fine lines and removes any dry patches. My skin looks years younger after month of use

0 people found this helpful

Profile picture of GANurse.

GANurse

from Georgia

Age Group: 50-59

Verified Purchase

March 14, 2026

Silky Smooth

I love how smooth and silky the product feels on my skin. Non-irritating on my neck and decollete.

0 people found this helpful

Profile picture of MAS01254.

MAS01254

Verified Purchase

March 13, 2026

Love this product

Use it day and night and want a difference it makes!

0 people found this helpful

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LovelySkin Customer

from Massachusetts

Verified Purchase

March 12, 2026

One of my favorite serums

Love this serum. However the new formula broke me out and I’m devastated.

0 people found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 60-69

Wavy, Dry Hair

Dry Skin

Verified Purchase

March 11, 2026

Relief for dry skin

I have mature dry skin. The Skin Medica line- specifically the HA5 Hydra really has helped combat my dry, tight- feeling skin this winter. I mix it in my moisturizer for best results for me.

0 people found this helpful

Profile picture of Crazysadie.

Crazysadie

from New York

Verified Purchase

March 10, 2026

Very Hydrating

I really like using this product, but wish that it wasn't so expensive. It hydrates and does the job that it's suppose to do.

1 person found this helpful

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LovelySkin Customer

Verified Purchase

March 10, 2026

SkinMedica HA5 Hydra Collegen Replenish

This is a great product for skin hydration, rejuvination. It goes on smoothly and dries quickly. I use it every morning as my first product after cleansing my face. Would definitely recommend it.

0 people found this helpful

Profile picture of Cathi.

Cathi

from Florida

Age Group: 70-79

Verified Purchase

March 09, 2026

Absolutely perfect for me!

I’m 71 and have been using HA5 for 2 years and use it morning and night. Immediately adsorbs, moisturizer and then foundation with SPF!

0 people found this helpful

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LovelySkin Customer

from Ohio

Age Group: 60-69

Verified Purchase

March 02, 2026

HA5

I have been using this for a while and it is a lightweight foam cleanser that I use in the morning. It makes your face feel fresh and hydrated. As far as taking makeup off in the evening I use a stronger cleanser but it is great for my morning cleanser to refresh my face

0 people found this helpful

Profile picture of BtflyATX.

BtflyATX

from Texas

Age Group: 60-69

Wavy Hair

Verified Purchase

February 28, 2026

My skin disapproves

I purchased 3 Skinceutical products at once so it took a minute to determine which was causing breakouts in my sensitive skin. I’m 100% certain this is the culprit. Additionally I saw no improvement in my wrinkles or brightness from my skin.

3 people found this helpful

Profile picture of Jules1.

Jules1

from Tennessee

Age Group: 50-59

Mature Skin

Verified Purchase

February 28, 2026

Good stuff!

I didn’t realize how much I like this product until I quoted using it.. I am happy to be using it again.

0 people found this helpful

Profile picture of Myskin.

Myskin

from Pennsylvania

Verified Purchase

February 24, 2026

Found it effective

This product was introduced to me by a Med Spa. I have mature skin, and to restore color, texture and plumpness to my facial skin was my main concern. This product is effective in doing all those things and more. My skin is softer, clearer and plumper with the proper hydration. It works well AM and PM. I apply it before foundation and the foundation goes on smoother and doesn't settle into pores. I found it effective as a solution to my concern.

3 people found this helpful

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LovelySkin Customer

from California

Verified Purchase

February 23, 2026

Skin Quench

I received a sample of this product and a friend also recommended it. I use it over a hyaluronic B 3. I absolutely love how my whole face, cheeks in particular, are never dry and dull looking. Seems to make the fine lines around the eyes and mouth almost disappear. Highly recommend.

2 people found this helpful

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LovelySkin Customer

Verified Purchase

February 23, 2026

SkinMedica HA5 Hidra Collagen

This Product is absolutely AMAZING!! My skin looks great! Thanks SkinMedica!!

1 person found this helpful

Profile picture of Bellagirl.

Bellagirl

from California

Age Group: 60-69

Curly Hair

Normal Skin

Verified Purchase

February 22, 2026

Great hydrator

I’m in my early 60’s & I’ve noticed how much better my skin looks since I started using this product. I feel like my skin is so smooth & soft now. I feel like it definitely plumps it & helps my mature skin look a bit younger too. I love this product.

1 person found this helpful

Profile picture of kwgoodman.

kwgoodman

from Georgia

Verified Purchase

February 22, 2026

Please bring back original!

I had the original HA5 on subscription and swore by it for years. This new formula causes a reaction and breaks out my face. I had to toss an entire bottle of it. I don't know what they did differently, but please bring back the original as an option!

6 people found this helpful

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