View more from SkinMedica

Earn & redeem Allē Rewards.
Learn More

SkinMedica TNS® Advanced+ Serum

1.0 oz
| HSA/FSA Eligible LMN Required
$295.00

Special Offer: 10% off use code SKMD10

View Details

Highlights
  • Fragrance-free
  • Boosts collagen and elastin production

Your subscription will continue until you cancel it

In stock & ready to ship!

Buy Now, Pay Later or
Free, fast shipping all U.S. orders, no minimums. 2-3 day delivery, most orders
Learn More
Authorized Retailer of SkinMedica
Authorized Retailer
Never receive a fake product
Learn More

Product Overview

SkinMedica TNS® Advanced+ Serum offers the classic formula, now supercharged.

This SkinMedica serum builds upon the legendary results of its predecessor for powerful anti-aging. Every piece of the TNS Essential serum, from the peptides to the growth factors has been rethought and amplified. Because of this, it’s even better at softening wrinkles, diminishing dark spots and addressing other signs of aging.

Formulated with TNS®-MR, the next-generation growth factor blend, this serum acts on multiple levels of the skin to achieve the best results. Additionally, Renessensce (RSC) Advanced, a highly active blend of botanicals, peptides and marine extracts, supports skin renewal for plumper, more youthful skin, delivering results in as little as two weeks.

Clinical Results:

  • Smooths visible coarse wrinkles and fine lines; with results starting as early as 2 weeks
  • Clinically proven to address sagging skin at week 8
  • Progressive results measured over 24 weeks

Key Features:

  • New Innovative 2 Tripeptide Complex visibly firms and smooths fine lines and wrinkles
  • Potent blend of Spanish Marine extract and Green Microalgae builds collagen and supports skin's repair process
  • Provides antioxidants for improved defense against environmental stress
  • Visibily lifts sagging skin while improving skin tone and texture
  • Fragrance-free and paraben-free

Highlights

  • Fragrance-free
  • Boosts collagen and elastin production
  • Contains growth factors

Ingredients

Directions

Shipping & Returns

Free U.S. Shipping. Period. View Our Shipping Policy

Return Policy: This product is non-returnable

Return Policy: View Our Return Policy

Special Shipping Requirements: ORM-D Class
ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! .

Questions & Answers (6)

Submit your question about this product to our talented team of Customer Care Representatives, and we'll get back to you as soon as possible!


Product Specifications

About the Brand

Customer Reviews (2036)

Overall Rating

4.6
Based on 2036 reviews

Review Summary

Write a Review

You can receive 50 rewards points by sharing your honest opinion of SkinMedica TNS® Advanced+ Serum.

Read all reviews

2036 Reviews

Default profile picture.

LovelySkin Customer

from Minnesota

Age Group: 70-79

Verified Purchase

October 12, 2026

Luxury in feel and easy to use day and night

I just started using this and already feel like it is a winner!

0 people found this helpful

Profile picture of Daphne1.

Daphne1

from California

Age Group: 70-79

Dry Skin

Verified Purchase

October 09, 2026

5 stars in waiting?

I haven’t used this too long but am liking A LOT what I am seeing. It seems to have softened lines and skin clearer. It is frightfully expensive so it will need to definitely become 5 star worthy if I purchase again but so far so good!

0 people found this helpful

Default profile picture.

LovelySkin Customer

from Tennessee

Age Group: 60-69

Verified Purchase

October 08, 2026

The Gold Standard in Skin Care

I never want to run out of this product!!!!

0 people found this helpful

Default profile picture.

LovelySkin Customer

Verified Purchase

October 07, 2026

Good product

I like this product a lot, but I'm not sure how much difference it makes for the price. I only purchase it when it's on sale, and I want to try one more round, but the cost for the amount is a lot. It didn't seem to last very long, and I only used it once a day.

0 people found this helpful

Default profile picture.

LovelySkin Customer

from Florida

Age Group: 30-39

Wavy Hair

Oily Skin

Verified Purchase

September 30, 2026

Amazing product!

I’ve been using for 2 years already & it’s one of my favorite products for anti-aging! Big fan of skin medica…highly recommended!

1 person found this helpful

Profile picture of btdt2.

btdt2

from Missouri

Age Group: 60-69

Verified Purchase

September 26, 2026

A Fan For Life!

What I love most about SkinMedica’s TNS Advanced+ Serum on a daily basis is how immediately satisfying it is to use. The texture is lightweight, absorbs effortlessly, and layers beautifully under my other products. From the very first week, it has kept my skin feeling incredibly soft, touchably smooth, and deeply hydrated. It gives my complexion that coveted plump, healthy, dewy look that makes me feel like I just stepped out of a high-end medical spa. For anyone hesitant about the investment, take it from someone who uses it religiously: it works. It doesn't just rest on top of your skin; it completely transforms your texture from the inside out. If you want a product that backs up its claims with actual visible smoothness and firmness, this is it. SkinMedica has a fan for life!

2 people found this helpful

Default profile picture.

LovelySkin Customer

from Illinois

Age Group: 50-59

Wavy, Dry Hair

Mature Skin

Verified Purchase

September 26, 2026

Soft, glowing skin

Love this serum! TNS Advanced+ has quickly become one of my favorite skincare products. My skin feels smoother, firmer, and more hydrated, and I’ve noticed an overall improvement in its texture and appearance. It’s definitely an investment, but a little goes a long way and I feel like I’m actually seeing results. Worth the splurge!

3 people found this helpful

Profile picture of Megg.

Megg

from Texas

Age Group: 50-59

Wavy, Dry Hair

Dry Skin

Verified Purchase

September 23, 2026

Seems to be working well

This seems to be helping the texture of my skin. I'm noticing less fine lines and crepiness. Only negative is that one side of the formula often seems to run out more quickly than the other even though I use equal amounts each time.

5 people found this helpful

Default profile picture.

LovelySkin Customer

from Oregon

Age Group: 50-59

Wavy, Color treated hair

Mature Skin

Verified Purchase

September 23, 2026

The Best

I've been using TNS 2x daily, including on my neck, for about 8 weeks. The softening of fine lines (and even deeper ones) is noticeable. I also use Skinmedica's Instant Bright Eye Cream. I finally ordered the Neck Correct Cream and will start using that for more focused treatment there, but TNS is a permanent part of my skincare routine.

5 people found this helpful

Default profile picture.

LovelySkin Customer

from Nebraska

Verified Purchase

September 22, 2026

Favorite skin care

Makes your skin feel great

3 people found this helpful

Default profile picture.

LovelySkin Customer

from Illinois

Verified Purchase

September 22, 2026

Love!

I would bathe in this serum if I could. I have used it for over 12 years and love how my face feels and looks.

4 people found this helpful

Default profile picture.

LovelySkin Customer

from Iowa

Age Group: 40-49

Verified Purchase

September 20, 2026

The high reviews are accurate

I gave TNS advanced+ serum a try based on an Allure magazine review. It is an amazing product. It has diminished fine lines and wrinkles around my eyes and lips and has given my skin a healthy glow. I acknowledge that it is costly. I'll continue to buy it as long as the formula doesn't change and the cost doesn't increase.

6 people found this helpful

Profile picture of CC11.

CC11

from Arizona

Verified Purchase

September 20, 2026

Great serum

I like this serum very much. I’m on my third order. It makes my skin very smooth and really does help fine lines and wrinkles. I plan to continue using this serum and highly recommend it.

5 people found this helpful

Profile picture of BTrapp.

BTrapp

from Louisiana

Age Group: 70-79

Mature Skin

Verified Purchase

September 18, 2026

Nothing better

I have been using this for years even before the package change. I tried cheaper products and some near the same cost but I keep coming back to this. It works for me. My lines are less noticeable and skin tone brighter when this is my product.

8 people found this helpful

Default profile picture.

LovelySkin Customer

from Pennsylvania

Age Group: 50-59

Verified Purchase

September 18, 2026

Can’t Go Without-

I’ve been using this for decades and I swear by it. Excellent product extremely effective can’t live without. You will see results. xx

4 people found this helpful

Default profile picture.

LovelySkin Customer

from California

Verified Purchase

September 18, 2026

Overpriced

The serums feel heavy and don't absorb well. Nearly no results. Overpriced. Worst of all, it is impossible to dispense both serums at a time! Totally defective design. May I have a refund, please?

4 people found this helpful

Default profile picture.

LovelySkin Customer

from Minnesota

Age Group: 40-49

Verified Purchase

September 14, 2026

My skin has never looked better!

Within two weeks my skin has completely transformed.

3 people found this helpful

Profile picture of LesPie.

LesPie

from Tennessee

Age Group: 60-69

Curly, Dry Hair

Mature Skin

Verified Purchase

September 13, 2026

Nice product!

I have used TNS serum on and off over the years and in the recent months I have started using it again. I can really see a difference in my skins texture and firmness. It is pricy but it is truly a quality product, especially for my mature skin.

3 people found this helpful

Profile picture of ASK.

ASK

from Nebraska

Verified Purchase

September 11, 2026

AK

Loving it so far! Been using for almost 3 weeks and my skin already seems brighter!

2 people found this helpful

Default profile picture.

LovelySkin Customer

from Washington

Verified Purchase

September 07, 2026

Great Transaction

Product sent/recieved in a timely manner, it was fresh and authentic.

2 people found this helpful

Top Picks



Loading
Return to the top