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SkinMedica TNS® Advanced+ Serum

1.0 oz
| HSA|FSA Eligible LMN Required
$295.00

Special Offer: 10% off use code SKMD10

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Highlights
  • Fragrance-free
  • Boosts collagen and elastin production
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Product Overview

SkinMedica TNS® Advanced+ Serum offers the classic formula, now supercharged.

This SkinMedica serum builds upon the legendary results of its predecessor for powerful anti-aging. Every piece of the TNS Essential serum, from the peptides to the growth factors has been rethought and amplified. Because of this, it’s even better at softening wrinkles, diminishing dark spots and addressing other signs of aging.

Formulated with TNS®-MR, the next-generation growth factor blend, this serum acts on multiple levels of the skin to achieve the best results. Additionally, Renessensce (RSC) Advanced, a highly active blend of botanicals, peptides and marine extracts, supports skin renewal for plumper, more youthful skin, delivering results in as little as two weeks.

Clinical Results:

  • Smooths visible coarse wrinkles and fine lines; with results starting as early as 2 weeks
  • Clinically proven to address sagging skin at week 8
  • Progressive results measured over 24 weeks

Key Features:

  • New Innovative 2 Tripeptide Complex visibly firms and smooths fine lines and wrinkles
  • Potent blend of Spanish Marine extract and Green Microalgae builds collagen and supports skin's repair process
  • Provides antioxidants for improved defense against environmental stress
  • Visibily lifts sagging skin while improving skin tone and texture
  • Fragrance-free and paraben-free

Highlights

  • Fragrance-free
  • Boosts collagen and elastin production
  • Contains growth factors

Ingredients

Directions

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ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! .

Questions & Answers (6)

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Product Specifications

About the Brand

Customer Reviews (1923)

Overall Rating

4.6
Based on 1923 reviews

Review Summary

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1923 Reviews

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LovelySkin Customer

Age Group: 50-59

Mature Skin

Verified Purchase

March 04, 2026

Good Product, but way to pricey

I have used this and a growth factor serum from a different brand and I think this one may have a tiny edge over the other brand in what it does for the skin, but not enough to warrant the much higher price. The other brand actually has pretty good sales, but unfortunately SkinMedica is one of those brands that rarely has sales and they are not too significant when they do. If you can afford the cost then I would say go for this one, but if you are trying to save a little and make your dollar go further than I would try the other.

0 people found this helpful

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LovelySkin Customer

from Montana

Age Group: 40-49

Verified Purchase

March 02, 2026

SkinMedica TNS

I absolutely love it. I can see difference already. Fine lines around my eyes are much softer, my skin looks “awake”, fresh! I have rosacea and very sensitive skin, I have zero reactivity to this product. Highly recommend! It is expensive but I purchased it when it was on sale so it was a little bit more affordable.

0 people found this helpful

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LovelySkin Customer

from Indiana

Age Group: 50-59

Verified Purchase

February 28, 2026

The best!

Love this product!

0 people found this helpful

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LovelySkin Customer

from Tennessee

Age Group: 80+

Straight Hair

Normal Skin

Verified Purchase

February 27, 2026

Love TNS

I have used TNS for years. It helps improve the texture of my skin and smooths out fine wrinkles. I tried other products but came back to TNS because I saw a difference. It’s the best even though it is expensive!

3 people found this helpful

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maryt

from Illinois

Age Group: 40-49

Wavy hair, Damage & split ends

Mature Skin

Verified Purchase

February 25, 2026

Awesome serum

Awesome serum, and the new packaging is a huge improvement

2 people found this helpful

Profile picture of Pati.

Pati

from North Carolina

Age Group: 60-69

Wavy Hair

Mature Skin

Verified Purchase

February 23, 2026

SkinMedica TNS Advanced+ Serum

I love this product and have been using it for years. My dermatologist recommended it.

3 people found this helpful

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Burg

from Virginia

Verified Purchase

February 21, 2026

Design Change

I am late to the design change of this dispenser. I DO NOT like the dual action pump. Small amounts of both ingredients do not come out equally. And then am I supposed to mix it myself? The product is excellent and I have been a loyal user since it was first introduced but thinking now of finding something simpler. This is not produced for the mature client but for youngsters who enjoy experimenting. At this price point, I expect fluidity.

3 people found this helpful

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ARosario

from Florida

Age Group: 50-59

Wavy Hair

Normal Skin

Verified Purchase

February 16, 2026

Hands down, a necessity for daily skincare

I’ve used this product for 15 years and my skin is noticeably different when I skip a day. It is light, effective and the perfect addition to my routine! It does what it says.

3 people found this helpful

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Rosalyn

from Ohio

Age Group: 50-59

Verified Purchase

February 12, 2026

tns serum

Wish I either didn't like it as much OR it was BOGO Lol

4 people found this helpful

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DanaAZ

from Arizona

Age Group: 60-69

Curly Hair

Mature Skin

Verified Purchase

February 11, 2026

Best ever!

I've been using this product for a decade. It's incredible for my skin and anti-aging. Everyone thinks I'm 15 years younger than i am. But the delivery system was not always terrific. They have now created a fail safe delivery system that ensures both products come out evenly and easily. Thank you so much skinmedica.

4 people found this helpful

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LovelySkin Customer

from Puerto Rico

Verified Purchase

February 10, 2026

Love

My favorite serum !! Mi skin look real radiant !! Is my second bottle .

0 people found this helpful

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Bengalgirl

Verified Purchase

February 08, 2026

Magic Product

This is worth every penny. It's helped more to clear up my skin than any acne med. I haven't used it long enough to judge antiaging benefits but based on results so far am very hopeful.

0 people found this helpful

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LovelySkin Customer

from Texas

Age Group: 70-79

Curly Hair

Normal Skin

Verified Purchase

February 06, 2026

Amazing!

I’ve been using TNS for a little over 2 years. My skin never looked so good. I highly recommend it!

1 person found this helpful

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HW

from South Carolina

Age Group: 40-49

Wavy, Color treated hair

Mature Skin

Verified Purchase

February 04, 2026

Funky Smell & Bad Pump

I wanted to love this, but the funky smell & malfunctioning pump were enough to override the positives. You can take the top apart and get more even distribution, but you shouldn’t have to. It definitely wastes some product until you get the pump working right. The smell is just plain bad, like something may have gone wrong. I also found that a different product gives my skin a better texture & glow, as a 49 year old dealing with some aging issues to address. It has growth factors as well, without the pump & smell issues.

3 people found this helpful

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LovelySkin Customer

from Virginia

Verified Purchase

January 30, 2026

Amazing

The product is amazing I seen results in just a few weeks!

1 person found this helpful

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JenniferJW

from Louisiana

Age Group: 50-59

Straight Hair

Mature Skin

Verified Purchase

January 28, 2026

SkinMedica TNS Advanced Serum

I love this product! I use it day and night and take it with me on all of my travels. I use it on the back of my hands too. Truly changes the appearance of your skin. Smoother, visible signs in texture and firmness.

2 people found this helpful

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Finn

from California

Verified Purchase

January 25, 2026

a must have serum

I highly recommend this product. my skin never have looked so gorgeous and plump. This is a product i can’t live without!

1 person found this helpful

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Awilson4

from Oklahoma

Age Group: 40-49

Straight, Color treated hair

Normal Skin

Verified Purchase

January 24, 2026

Still unsure

I really wanted to add an EGF into my routine and gave this a try. I really like the consistency and the way it lays on my skin but I haven't really noticed any changes or positive improvements to my skin. I think you have to give it every 60 days but based off of the cost I don't think I'm going to purchase this again. I do use other skin medical products I just don't think this one's for me.

3 people found this helpful

Profile picture of HeidiL.

HeidiL

Age Group: 30-39

Wavy Hair

Dry Skin

Verified Purchase

January 21, 2026

One of My Favorites

I use this nightly as part of my routine to age gracefully, and it has become a must have for me. My skin feels smoother, firmer, and more refreshed, and I love knowing I am investing in long term skin health.

2 people found this helpful

Profile picture of ROMANHOLIDAY.

ROMANHOLIDAY

Age Group: 70-79

Mature Skin

Verified Purchase

January 20, 2026

TNS Advanced Miracle Prodent

I haven't written a review about the new packaging of this supurb product. The new pump system is a vast imporvement over the old bottle. It is much easier to select each pump for distribution and they don't clog the way the old ones used to, The product is always spectacular - I have been using is for years. and although I recently turned 75, people always comment that I look in my 50s!! Try the new packaging and see for yourself!

8 people found this helpful

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