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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum

1.0 fl oz
| HSA/FSA Eligible LMN Required
$150.00

Special Offer: Free $20 SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum Deluxe Trial Size!

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Highlights
  • Smooths 9 types of expression lines
  • Complements neurotoxin injections

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum helps reduce nine types of contraction lines and promotes glass skin radiance.

Inspired by the effects of neurotoxin injections, this serum is formulated with an Advanced Peptide Complex and a Glass Skin Complex to smooth nine types of contraction and expression lines to rejuvenate skin for a renewed glow. Neurotoxin injections are a popular in-office treatment used to treat expression wrinkles caused by muscle contractions. 

When paired together, P-TIOX and neurotoxin injections work synergistically to help reduce the appearance of wrinkles, delivering fast, long-lasting results. Versatile and innovative, this serum is also effective on its own to smooth skin, refine pores and reveal glass skin radiance in one week of use. 

Clinical Results:

  • Improves skin smoothness, refines the look of pores and reveals glass skin radiance in one week
  • Visibly reduces fine lines in one week
  • Visibly reduces nine types of contraction lines, even those hard to treat with neurotoxin injections after 12 weeks
  • Visibly reduces global fine lines by 20.6% in 12 weeks

Key Features:

  • Advanced Peptide Complex, comprised of 2% hexapeptide and 2% dipeptide, works together in synergy to fight against contraction lines
  • 5% PHA, 5% niacinamide, and 1% laminaria extract maximize hydration while gently exfoliating to visibly improve skin texture and radiance
  • Tested on all skin tones and types
  • Hydrates skin up to 24 hours after application

SkinCeuticals is removing the plastic shrink seal around the neck of SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum as part of its commitment to sustainability. The tamper-proof outer carton seal remains unchanged, and rigorous testing confirms full bottle and formula integrity.

Highlights

  • Smooths 9 types of expression lines
  • Complements neurotoxin injections
  • Reveals glass skin radiance

Ingredients

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Questions & Answers (8)

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Product Specifications

About the Brand

Customer Reviews (326)

Overall Rating

4.4
Based on 326 reviews

Review Summary

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326 Reviews

Profile picture of AmandaSpears.

AmandaSpears

from Maryland

Age Group: 50-59

Wavy, Dry Hair

Dry Skin

Verified Purchase

October 22, 2026

it's just ok, it moisturizes

I think it helps with moisturizing but not sure what it does else otherwise.

1 person found this helpful

Profile picture of Chris11.

Chris11

from Massachusetts

Age Group: 40-49

Verified Purchase

October 12, 2026

Believe the Hype

The glass skin promises of this serum are real, but temper your expectations if you're expecting it to freeze your face - those properties are subtle. Another indelible entry into the SkinCeuticals line up - I think I've just gone through what must be by 6th or 7th bottle.

0 people found this helpful

Profile picture of LTS.

LTS

from North Carolina

Age Group: 70-79

Verified Purchase

October 08, 2026

Was Excited Then Disappointed

I wanted to try this product and was excited to receive it. I used it for a week and sadly had an allergic reaction. Had to return the product. As a decades long Skinceuticals user of multiple products, this is the first Skinceuticals product to cause a negative skin reaction.

3 people found this helpful

Profile picture of RMR3958.

RMR3958

from Pennsylvania

Age Group: 60-69

Wavy, Color treated hair

Mature Skin

Verified Purchase

October 06, 2026

Magic in a bottle

My daughter let me use hers and it’s truly magic in a bottle. Six drops over my problem area’s and within a few weeks the wrinkles are starting to disappear.

2 people found this helpful

Profile picture of ICU.

ICU

from New Jersey

Age Group: 80+

Straight, Color treated hair

Normal Skin

Verified Purchase

October 03, 2026

WOW

Have been using the P-TIOX for a week and it has softened my very deep expression lines. I hope with continued use it will soften them even more.. SkinCeuticals makes products that work.

3 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 50-59

Verified Purchase

September 30, 2026

P-TIOX Wrinkle Modulating Peptide Serum

I purchased the P-TIOX Wrinkle Modulating Peptide Serum along with the P-TIOX Wrinkle Modulating Peptide Cream. I saw a difference immediately!!! I'm completely sold on Skinceuticals & will be converting over from the brand I've been using. May be a little pricey, but well worth the money & if used appropriately...will go a long way.

3 people found this helpful

Profile picture of Glowzilla.

Glowzilla

from New York

Age Group: 40-49

Wavy, Dry Hair

Dry Skin

Verified Purchase

September 25, 2026

Holy Grail serum

I would take this to my grave... I get neuromodulators, and this works a treat with them. I have been using it for a couple of years and fine lines are gone, pores are small, skin is smooth.

2 people found this helpful

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LovelySkin Customer

from New Jersey

Age Group: 50-59

Normal Skin

Verified Purchase

September 22, 2026

unbelievable

I did not believe it would really get rid of wrinkle, but kept using it. After a couple weeks, my skin looks amazing. I stopped using it when I ran out, and noticed a difference in the skin texture and fine lines within 2-3 weeks. I guess it really works!

2 people found this helpful

Profile picture of Renzy.

Renzy

Age Group: 50-59

Mature Skin

Verified Purchase

September 19, 2026

Great after botox

Love to use this serum after injections and in between next ones. Helps expression lines.

2 people found this helpful

Profile picture of JuW.

JuW

Verified Purchase

September 19, 2026

Good serum

I use the serum in the morning with a sunscreen and the cream at night. It really helps minimizing the pores and make my skin feel even and nice.

1 person found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 60-69

Mature Skin

Verified Purchase

September 18, 2026

Nice Product

I have been using this product for months and I do think it has improved the appearance of my forehead wrinkles. However, I would not say it gives me "glass like skin" as advertised. I would purchase again.

3 people found this helpful

Profile picture of Jesse.

Jesse

from Pennsylvania

Verified Purchase

September 16, 2026

P-Tiox serum

I was reading a lot about this product. Decided to try. I’m amazed at how smooth this product is making my face! Was reading maybe glass skin?? Not sure if I have noticed less wrinkles, but only using it maybe 2 weeks. Def really pleased with what I’m seeing!!!

3 people found this helpful

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LovelySkin Customer

from Puerto Rico

Age Group: 40-49

Verified Purchase

September 16, 2026

Best product ever!

I will buy this product again.

3 people found this helpful

Profile picture of AbbyB19.

AbbyB19

from Michigan

Verified Purchase

August 31, 2026

A keeper

I use the ptiox serum and cream by skinceuticals twice per day. I find an immediate improvement in the appearance of my skin and I feel its condition has improved since using them

2 people found this helpful

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LovelySkin Customer

Age Group: 50-59

Verified Purchase

August 26, 2026

Lovely Serum!

My absolute favorite product right now - it has really improved the bounce and glow to my skin. I was so impressed that I bought the moisturizer.

4 people found this helpful

Profile picture of TexasBarb.

TexasBarb

from Texas

Age Group: 60-69

Wavy hair, Damage & split ends

Mature Skin

Verified Purchase

August 25, 2026

Great after Botox

I've been using this product for several years, and it's really help maintain my Botox. I put it on my forehead and around my mouth, and I see really great results. I recommend this product.

3 people found this helpful

Profile picture of GabrielaP.

GabrielaP

from California

Verified Purchase

August 20, 2026

Fantastic result!

This serum is phenomenal! I use it in the morning and I use the cream version at night. I immediately leaves my skin feeling moisturised and glowing. I will continue to use.

1 person found this helpful

Profile picture of Painswick.

Painswick

from Arizona

Age Group: 80+

Wavy Hair

Mature Skin

Verified Purchase

August 13, 2026

Amazing serum

The texture of my skin since using is very smooth. I have never had injections but I am doing red light therapy & using serum morning and evening. I am 85 & only have expression lines. I am very pleased with this regimen; I get lots of compliments on my skin.

5 people found this helpful

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LovelySkin Customer

from Pennsylvania

Age Group: 20-29

Normal Skin

Verified Purchase

August 05, 2026

My 2nd bottle, love it!

This is an amazing peptide serum, the texture is lovely & it definitely has improved the quality of my skin. I’ve noticed improvement in a fine line & brightening around the eyes. This is a great preventative product and lasts awhile.

1 person found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 40-49

Straight hair, Damage & split ends

Normal Skin

Verified Purchase

August 04, 2026

miracle serum

i ended up buying this after getting a couple samples. it was an instantaneous difference in my skin. it’s a staple in my night time and day time regimen now!

1 person found this helpful

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