ISDIN Isdinceutics Retinal Advanced

ISDIN Isdinceutics Retinal Advanced Dual-Phase Night Serum

1.7 fl oz

4.7 View 42 reviews

| HSA/FSA Eligible LMN Required

$185.00

Highlights

Suitable for all skin types
Brings back elasticity and firmness
Hydrates and calms skin with a soothing complex

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Product Overview

ISDIN Isdinceutics Retinal Advanced Dual-Phase Night Serum visibly smooths while you sleep.

This nighttime treatment features dual-phase technology. While in the bottle, the treatment exists as two different serums, a more emollient one with retinaldehyde and a lighter one with a soothing complex. They combine right when you use the treatment to keep the retinaldehyde potent and create a lovely texture.

Clinical Results (One Month):

43% reduction in wrinkles

Consumer Results (Three Months):

90% observed renewed skin
97% observed firmer skin
97% observed no discomfort
97% observed a reduction of wrinkles and fine lines

Key Features:

Reduces visible wrinkles in just one month
Addresses discoloration and redness with niacinamide
Combines 0.1% retinaldehyde with bakuchiol, a natural retinol-like extract

Highlights

Suitable for all skin types
Brings back elasticity and firmness
Hydrates and calms skin with a soothing complex

Ingredients

Directions

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Questions & Answers (3)

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Product Specifications

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Customer Reviews (42)

Overall Rating

4.7

Based on 42 reviews

Review Summary

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42 Reviews

djc1110

from Texas

Age Group: 70-79

Mature Skin

Verified Purchase

February 20, 2026

Great product(s)!

I absolutely love this product! It has made such a difference in the way my skin feels. No longer the dry feeling at night. I have been using Isdin products for over a year now, on the recommendation of my dermatologist

0 people found this helpful

Emmarand

from Maine

Age Group: 40-49

Combination Skin

Verified Purchase

February 20, 2026

Luxurious

Love it! Ordered it by accident and would definitely order it again.

1 person found this helpful

CherG

from Massachusetts

Verified Purchase

February 07, 2026

Great Retinol Formula

I like this product which is recommended by my dermatologist. Leaves my skin very smooth. No irritation at all.

0 people found this helpful

LovelySkin Customer

from Massachusetts

Age Group: 60-69

Straight Hair

Combination Skin

Verified Purchase

January 21, 2026

Love it!

I use the ISDIN retinal advanced night serum after washing my face in the evening and I absolutely notice a difference in my skin. It took a few weeks before I really noticed a difference but I am hooked and will continue to use this product. My dermatologist recommended it and I am so glad that they did.

2 people found this helpful

LovelySkin Customer

from Florida

Age Group: 70-79

Verified Purchase

November 11, 2025

ISDIN NIGHT SERUM

I recently started using this serum and like the texture of the serum very much. However, I have not noticed any noticeable changes in my skin at this time.

2 people found this helpful

Mamadop

from New York

Age Group: 60-69

Curly Hair

Mature Skin

Verified Purchase

October 28, 2025

Unbelievable!!

ISDIN retinal advanced dual phase night serum is awesome… my skin has NEVER felt smoother or looked better!!! I highly recommend.. you won’t be sorry!!!

3 people found this helpful

Lovelyskinat60

from Massachusetts

Verified Purchase

August 26, 2025

Liquid Gold

I use retinal as part of my daily nightly routine, but I have not found one that that I love as much as this one. It is pure luxury. I use it after a couple of lightweight serums, and then top it off with Isdin's Melatonik for top notch results. This is a must-have product for retinal users. I highly recommend.

1 person found this helpful

Jesse

Verified Purchase

August 02, 2025

ISDIN Retinol Advanced Serum

I really like the ISDIN

1 person found this helpful

Marshie

from New York

Dry Skin

Verified Purchase

July 11, 2025

Lovely Serum

Easy to apply. Go on smoothly. A little goes a long way. Very gentle on skin. Too soon to determine any reduction of fine lines and wrinkles.

2 people found this helpful

LovelySkin Customer

Verified Purchase

May 18, 2025

My favorite night time routine

I absolutely love this product. I wake up with smooth and glowing skin. It isn't irritating as other retinols I have used in the past. I will keep using ISDIN Retinal Advanced!!

2 people found this helpful

MariaCampos

Verified Purchase

May 12, 2025

favorite in my skincare routin

I’ve been using this retinol for a few weeks now and I’m seriously impressed. My skin feels smoother, looks more even. It’s gentle enough that I didn’t experience any major irritation, but still effective.

1 person found this helpful

LovelySkin Customer

Verified Purchase

April 29, 2025

Love ISDIN

I love this retinal cream by ISDIN. It is not as harsh as the regular RetinA. It feels great on the skin. I like the dual chamber and it mixes well. Highly recommend especially if you cannot tolerate tretinoin/ RetinA.

1 person found this helpful

dsnc109

Verified Purchase

February 27, 2025

Great serum

I have finally found a serum that I am in love with. This serum does what it says. I wake up with an even and smooth complexion every morning. Really has made a difference in wearing makeup too as the skin is smooth and even toned. I plan on getting some more of this even before I run out of the one I am currently using just so I won't run out.

2 people found this helpful

ArtistAnn

Verified Purchase

February 02, 2025

Works for smoother, brighter skin

Love this product! I am in my 70s so, not a spring chick! If it works for me it will work for you!

4 people found this helpful

LovelySkin Customer

Verified Purchase

January 11, 2025

amazing retinol

Feel like it is strong and working but does not burn like others have and can tell it is already working!

0 people found this helpful

LovelySkin Customer

Verified Purchase

January 03, 2025

Great Retinal Serum

I had been purchasing this serum years before Lovely Skin sold the product on the advice of my dermatologist. It dispenses perfectly from the dual chambers and can then be blended on the back of my hand. One pump per night goes a long way! A great retinal option!

3 people found this helpful

suzy

Verified Purchase

January 02, 2025

Great Serum

Helps my skin look fresher in the morning. Goes on very easily. Would prefer a single chamber dispenser, though. So far, it works fine.

1 person found this helpful

CMC11

Verified Purchase

December 10, 2024

Great Product!

I have only been using this product for a few weeks so I haven't seen a noticeable difference yet. I have extremely sensitive skin and have a hard time with retinols. I use other ISDIN products and decided to try this one. Love the pump! I've had trouble with other brands and pumps. This one is perfect. Two pumps on my fingers, rub together and smooth over the face. I can almost feel the tingling from the start. Once it dries, I follow with moisturizer. Used every other night for a week until my skin was ready for every night. There is a little dryness/flaky skin the next day. The reason I gave it 4 stars is due to the fragrance. I don't care for it. It does dissipate within a reasonable amount of time. That won't keep me from purchasing again.

1 person found this helpful

Spaskin

Verified Purchase

December 06, 2024

Age Reversal!

Received the Retinal Advanced as a sample, and it's made a big impact on my skin! You can feel it working the moment you apply it, and it's not drying which is a bonus! I've already noticed some dark spots lightening, and my skin is very smooth. I'm in my early 60s and this will become a forever product for me to use.

0 people found this helpful

LovelySkin Customer

Verified Purchase

December 01, 2024

Holy Grail!

I’ve been using this product for about 3 months now. I can definitely see the difference in my skin. Very smooth textured skin now, and the wrinkle in my forehead is gone.

1 person found this helpful

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ISDIN Isdinceutics Retinal Advanced Dual-Phase Night Serum

Product Overview

ISDIN Isdinceutics Retinal Advanced Dual-Phase Night Serum visibly smooths while you sleep.

Highlights

Ingredients

Directions

Shipping & Returns

Questions & Answers (3)

Product Specifications

Featured In

Customer Reviews (42)

Overall Rating

Review Summary

Write a Review

Great product(s)!

Luxurious

Great Retinol Formula

Love it!

ISDIN NIGHT SERUM

Unbelievable!!

Liquid Gold

ISDIN Retinol Advanced Serum

Lovely Serum

My favorite night time routine

favorite in my skincare routin

Love ISDIN

Great serum

Works for smoother, brighter skin

amazing retinol

Great Retinal Serum

Great Serum

Great Product!

Age Reversal!

Holy Grail!

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