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SkinCeuticals Advanced RGN-6 Regenerative Cream

1.7 fl oz
| HSA|FSA Eligible LMN Required
$195.00
Highlights
  • Can be used on all skin types
  • Encourages smoother, firmer, more even skin
  • Brightens the appearance of dark spots
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Product Overview

SkinCeuticals Advanced RGN-6 Regenerative Cream helps regenerate skin while improving six signs of aging.

Inspired by laser regeneration science, this powerful cream helps improve skin tone damage and signs of aging. Its patented formula contains six key ingredients to improve redness, stubborn discoloration and wrinkles with visible results in as little as one week. 10% Glyco-Repair™, a nutrient-dense derivative of carob seeds, helps trigger barrier repair and renew skin texture while 1% eperuline, derived from eperua falcata bark, soothes skin and reduces signs of aging. 2% niacinamide helps reduce the appearance of discoloration and strengthen the skin barrier while 0.2% ectoin, an amino acid derivative, helps soothe, hydrate and prevent oxidative damage. Lastly, 0.2% Bioceramide 603, a patented, exclusive ceramide that's bioavailable to the skin, targets discoloration and supports skin barrier function.

Clinical Results (12 weeks):

  • 69% Reduction in visible redness
  • 36% Reduction in post-acne marks
  • 26% Reduction in dark spots
  • 18% Reduction in wrinkles
  • 35% Increase in smoothness
  • 35% Increase in firmness

Key Features:

  • Developed to be used as part of a daily routine and alongside in-office laser procedures
  • Helps reduce downtime post-procedure for improved texture and hydration
  • Promotes skin barrier repair, improves the look of discoloration and reduces visible redness post-treatment

Highlights

  • Can be used on all skin types
  • Encourages smoother, firmer, more even skin
  • Brightens the appearance of dark spots

Ingredients

Directions

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ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! . Ships within the U.S. only.

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Product Specifications

About the Brand

Customer Reviews (39)

Overall Rating

4.5
Based on 39 reviews

Review Summary

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39 Reviews

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LovelySkin Customer

Verified Purchase

December 03, 2025

New favorite SkinCeuticals product.....

that I can't live without! I thought I'd give it a try as I am loyal to SkinCeuticals. I've almost finished my first bottle (I just ordered a 2nd) and I believe it transformed my skin! It is pricey and since I don't do lasers or any facial treatments, I briefly hesitated on buying this 2nd bottle but so glad I did. In my opinion, it's magical!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

October 22, 2025

Soothing

I used this after microneedling and it was very soothing and helped my skin recover faster. I have also used it other times when my skin felt irritated and got immediate relief. I will continue using as needed and plan to repurchase. Shared information with my esthetician.

0 people found this helpful

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Jess2

from Puerto Rico

Age Group: 40-49

Wavy hair, Damage & split ends

Combination Skin

Verified Purchase

October 10, 2025

Amazing

Im 45 years old and I only use Skinceutical producs, that are quite expensive but worth ever penny. This is a MUST have for aging skin.

1 person found this helpful

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Broncobarb

from Florida

Age Group: 60-69

Mature Skin

Verified Purchase

October 08, 2025

RGN-6 Regenerative Cream

I have purchased this twice and have been using it after C02 Laser. It did not irritate, and I believe it helped improve the red skin. It is difficult to tell when it is going to run out because you cannot see thru the bottle and it heavy.

2 people found this helpful

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LovelySkin Customer

from California

Age Group: 60-69

Mature Skin

Verified Purchase

October 08, 2025

This is very moisturizing

I like this product. This product is good for layering with a heavier moisturizer or during the summer. I have not seen any anti-aging benefits, but it is a good light-weight moisturizer.

0 people found this helpful

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JaniceMary

from Colorado

Age Group: 70-79

Straight hair, Damage & split ends

Mature Skin

Verified Purchase

October 08, 2025

Love This New Regenerative Cream

I have been using the new regenerative cream by SkinCeutical for 2 weeks now, and my skin looks so much clearer. I use it morning and night. It is a little pricey, but it will last a long time....and I am worth it :)

0 people found this helpful

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lss

Verified Purchase

October 02, 2025

Not a miracle in a bottle

Expensive for what you get. I don't think it is "advanced" and I am not seeing any results. For the price I want to see some changes. Will move onto a different product.

3 people found this helpful

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PC13

from Texas

Verified Purchase

October 01, 2025

Did Not Like

This is one Skinceuticals product I did not like. This was really drying to my skin and I should have stopped using it sooner. It also made my dark spots darker and that made me mad!! It was an expensive mistake, but I really wanted to try it.

1 person found this helpful

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Nakshi

from California

Age Group: 30-39

Straight, Color treated hair

Dry Skin

Verified Purchase

September 27, 2025

Must have !!

Now I’m going to buy the 3rd bottle.. it work on me so well . I recommend surely

0 people found this helpful

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LovelySkin Customer

from Wisconsin

Mature Skin

Verified Purchase

September 16, 2025

Nice but could be better

I love the pump packaging and texture of this product. Nice list of ingredients which I was excited about. It doesn’t take a lot to cover my face so the bottle should last longer than my SC jar moisturizers. This does feel nice on my skin but, even in Summer, this isn’t hydrating enough for my dry mature skin. I am using it as a final serum/pre-moisturizer. This has many excellent reviews and I agree that this is an excellent product for many people. I’m just not sure it is worthwhile for me to buy again. I think SC suggests this for all skin types but maybe not the best for super dry mature skins or at least mine. Still an excellent product that is worth trying. I’m hoping they come out with a rich version.

1 person found this helpful

Profile picture of Peachie.

Peachie

from Georgia

Verified Purchase

August 29, 2025

convenient

I have been using this for a few weeks and the jury is still out. It does absorb easily but doesn't feel as moisturizing as AGE Interrupter or the Lipid Cream. Will be a while before I am sure which is best for me. It does have a very nice fragrance.

1 person found this helpful

Profile picture of Josephine.

Josephine

from California

Verified Purchase

August 25, 2025

SkinCeuticals RGN-6

Product is fabulous. My skin is hydrated and much smoother. The fine lines I had are no longer noticeable. Overall, face redness is diminished and skin texture is much improved. Definitely recommend product.

1 person found this helpful

Profile picture of Wilmarie.

Wilmarie

from Puerto Rico

Age Group: 60-69

Straight, Color treated hair

Combination Skin

Verified Purchase

August 18, 2025

Advance RGN-6 Regenerative cream

I've been using Advance RGN-6 for about a month and a half. My skin looks more moisturized, clearer (the redness has decreased), and my expression lines have softened and my skin is smoother. I recommend it 100%.

2 people found this helpful

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sdell

from Illinois

Age Group: 50-59

Curly, Color treated hair

Mature Skin

Verified Purchase

August 08, 2025

enjoy using every morning!

part of my morning routine. Not sticky or gooey, and makeup application is perfect.

0 people found this helpful

Profile picture of SSW.

SSW

from Kansas

Age Group: 60-69

Dry Skin

Verified Purchase

July 29, 2025

1st time user

The RGN-6 Regenerative Cream is a must have. I have never used it before but I will be a repeat buyer of this product.

2 people found this helpful

Profile picture of CharlieC.

CharlieC

Verified Purchase

July 29, 2025

Great product

This is a great overall product. I used it after minimally invasive laser resurfacing and it seemed to heal a lot quicker with less peeling. I also notice an overall better glow and plumpness that I didn’t have before. I get laser often so it was definitely different than getting laser without using this product and I have had no bad skin reactions and I actually notice a lightening of my dark spots during the summer months where there is sun exposure soo that’s pretty impressive!!!

3 people found this helpful

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LovelySkin Customer

from California

Age Group: 60-69

Mature Skin

Verified Purchase

July 24, 2025

Great!

This cream is wonderful. Of course, it's a Skinceutical product! I'm so happy Lovely Skin carries Skinceuticals products. I always get them for a great price.

2 people found this helpful

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Priz

from Wisconsin

Verified Purchase

July 24, 2025

Honestly

Have been using this new product for several weeks now and honestly it’s too soon to tell. I like the texture of the product and my skin feels soft but it needs more time to notice a difference.

0 people found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 80+

Straight, Dry Hair

Dry Skin

Verified Purchase

July 19, 2025

Regenerative cream

I’ve been using the Regenerative cream for a month and I notice softer skin and the fine lines have diminished. I really like how it feels on my skin.

3 people found this helpful

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LovelySkin Customer

from California

Verified Purchase

July 19, 2025

Skin care

So far very happy with this new product. I use this morning and evening, the week before an in office procedure and a few days after. It seems to help my skin heal. All I can say is my skin looks great. Getting lots of compliments! Expensive but you only use a little each time. Totally try it!

0 people found this helpful

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