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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum

1.0 fl oz
| HSA/FSA Eligible LMN Required
$150.00

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Highlights
  • Smooths 9 types of expression lines
  • Complements neurotoxin injections

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum helps reduce nine types of contraction lines and promotes glass skin radiance.

Inspired by the effects of neurotoxin injections, this serum is formulated with an Advanced Peptide Complex and a Glass Skin Complex to smooth nine types of contraction and expression lines to rejuvenate skin for a renewed glow. Neurotoxin injections are a popular in-office treatment used to treat expression wrinkles caused by muscle contractions. 

When paired together, P-TIOX and neurotoxin injections work synergistically to help reduce the appearance of wrinkles, delivering fast, long-lasting results. Versatile and innovative, this serum is also effective on its own to smooth skin, refine pores and reveal glass skin radiance in one week of use. 

Clinical Results:

  • Improves skin smoothness, refines the look of pores and reveals glass skin radiance in one week
  • Visibly reduces fine lines in one week
  • Visibly reduces nine types of contraction lines, even those hard to treat with neurotoxin injections after 12 weeks
  • Visibly reduces global fine lines by 20.6% in 12 weeks

Key Features:

  • Advanced Peptide Complex, comprised of 2% hexapeptide and 2% dipeptide, works together in synergy to fight against contraction lines
  • 5% PHA, 5% niacinamide, and 1% laminaria extract maximize hydration while gently exfoliating to visibly improve skin texture and radiance
  • Tested on all skin tones and types
  • Hydrates skin up to 24 hours after application

SkinCeuticals is removing the plastic shrink seal around the neck of SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum as part of its commitment to sustainability. The tamper-proof outer carton seal remains unchanged, and rigorous testing confirms full bottle and formula integrity.

Highlights

  • Smooths 9 types of expression lines
  • Complements neurotoxin injections
  • Reveals glass skin radiance

Ingredients

Directions

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Questions & Answers (8)

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Product Specifications

About the Brand

Customer Reviews (302)

Overall Rating

4.4
Based on 302 reviews

Review Summary

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302 Reviews

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LovelySkin Customer

from Florida

Age Group: 30-39

Verified Purchase

July 19, 2026

Love!

This product has been a great addition to my skin care routine. It’s smooth and soaks right into my face nicely!

0 people found this helpful

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Molecule

from Arizona

Mature Skin

Verified Purchase

July 19, 2026

Skinceuticals is the best!

I love Skinceutical products! This serum goes on easy and paired with the P-Tiox cream, it leaves my skin feeling like smooth silk. I have used Skinceutical products for several years and they all are wonderful! I've tried other brands and always returns to Skinceutical products. I won't be buying anything else from now on. Their products last a long time and you don't have to use a lot for great results.

0 people found this helpful

Profile picture of GoJo.

GoJo

from Illinois

Age Group: 70-79

Mature Skin

Verified Purchase

July 04, 2026

Great results!

In just a little over a week I can see this product is making a huge difference!

5 people found this helpful

Profile picture of Dovey.

Dovey

from Pennsylvania

Age Group: 60-69

Straight, Color treated hair

Dry Skin

Verified Purchase

June 28, 2026

Exceptional Results

This is the best serum I’ve found for my aging skin. Results for me are usually subtle, but with P-TIOX I saw a very noticeable improvement in lines and wrinkles as well as a more refined texture. I follow it with Skinceuticals A.G.E. Interrupter cream at night.

8 people found this helpful

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SM28

from Puerto Rico

Age Group: 30-39

Oily Skin

Verified Purchase

June 27, 2026

Too pricey for the hype

The hype on this product is real!! Too pricey for what is says to achieve. I do use retinol and other products so I can’t really tell or say honestly that this does help with fine lines or wrinkles because I haven’t seen any results from one bottle. I do like the glow I have in the morning from it and it does leave this healthy shine, but that’s not the point to spend this nuch money.

6 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 70-79

Curly, Color treated hair

Combination Skin

Verified Purchase

June 26, 2026

Not a fan

Tried the SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum but not impressed enough with the results to reorder. You can only layer two or three treatment products on your face and there are more effective serums on the market than this one.

8 people found this helpful

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Marsh

from North Carolina

Verified Purchase

June 19, 2026

SkinCeuticals P-TIOX Wrinkle Modulating Peptide

I have been using this in complete with the cream and my skin looks good and I can tell a difference

4 people found this helpful

Profile picture of CMN.

CMN

from Washington

Age Group: 40-49

Normal Skin

Verified Purchase

June 08, 2026

SC P-TIOX

I’m loving this stuff. It’s making my skin so soft and smooth. Gentle yet so very effective. I highly recommend

6 people found this helpful

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LovelySkin Customer

Verified Purchase

June 07, 2026

Crepiness and acne

I have sensitive, redness prone, normal-to-dry skin with acne rosacea. P-TIOX didn't work as well as expected and caused crepiness and acne.

12 people found this helpful

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LovelySkin Customer

from Colorado

Age Group: 60-69

Wavy, Color treated hair

Mature Skin

Verified Purchase

June 03, 2026

I just started, I LIKE IT!!!

I was Lasered a month ago.....And to maintain healing & Smooth Skin THIS HELPS!!! Yes Diet, Protein, Hydration, & Exercise is very important!!! BUT I HAVE BEEN USING it & I WILL FOLLOW THROUGH!!! THANK YOU for the VIDEO instruction & Honest from the "Docs"!!!!

5 people found this helpful

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LovelySkin Customer

from Ohio

Verified Purchase

June 02, 2026

Glass skin glow

This is my second bottle of P-TIOX that I have purchased. I am not so sure it really makes lines and wrinkles look softer but it does give your face a healthy radiant look. It is on the pricey side so I will decide after this bottle if it is worth repurchasing

13 people found this helpful

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LovelySkin Customer

from Puerto Rico

Age Group: 30-39

Wavy, Color treated hair

Dry Skin

Verified Purchase

June 02, 2026

Best product

Life changing product.

3 people found this helpful

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NonprofitBanker

from California

Age Group: 60-69

Mature Skin

Verified Purchase

May 23, 2026

P-Tiox winner

On my 3rd bottle of P-tiox and find it calms my skin down. I use with other suggested SkinCeuticals products for beautiful skin.

2 people found this helpful

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LovelySkin Customer

from Wisconsin

Verified Purchase

May 23, 2026

Softened Fine Lines

This is my second purchase of this product and will continue use. It softened the fine laugh lines.

2 people found this helpful

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CharlieC

Verified Purchase

May 16, 2026

Great long term results

Love this because it is very thin and dries quickly. I use it on my smile lines under eyes and 11 lines underneath any other creams and serums/treatments. I didn’t realize how much it actually did until I quit using it temporarily and noticed my lines slowly peeking through again. It definitely works on fine lines and the longer I use it the better the results seem to get.

2 people found this helpful

Profile picture of BYG.

BYG

from North Carolina

Age Group: 60-69

Wavy Hair

Mature Skin

Verified Purchase

May 12, 2026

Fantastic product

I received a sample of P-Tiox and glad I did! This is another great product from skinceuticals. I’ve been skeptical until now about the results it could deliver. Well it does. Just follow the instructions

1 person found this helpful

Profile picture of MIAMIJOSHUATREE.

MIAMIJOSHUATREE

from Florida

Age Group: 50-59

Straight, Color treated hair

Normal Skin

Verified Purchase

May 05, 2026

Great Product!!

I use it after my SERUM 10 product. I love the P-TIOX I use it every morning!

1 person found this helpful

Profile picture of Bailyboo.

Bailyboo

from Florida

Age Group: 70-79

Straight Hair

Dry Skin

Verified Purchase

April 27, 2026

Works

I am really loving this product I feel it helps my skin look soft I use it at night but going to start in the morning I am 74 I always get stop about my skin I always had beautiful skin but even at 74 going on 75 i myself am surprised it looks soft and almost glass looking after I wake up in the morning it ‘s really plumped up also .i feel it worth the price if it works and this does for me .

1 person found this helpful

Profile picture of Lpetra.

Lpetra

from Oregon

Age Group: 50-59

Mature Skin

Verified Purchase

April 22, 2026

Not worth the money

Love Skinceuticals but no this. This really didn't do anything for my skin or wrinkles. I used it day and night as suggested until the bottle was empty and did not notice anything at all.

11 people found this helpful

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LovelySkin Customer

Age Group: 40-49

Verified Purchase

April 15, 2026

The product does help.

I have used the product for 5 months, and I can see the wrinkles are not as obvious as before.

1 person found this helpful

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