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GlyDerm Cream Plus 12% 1.5 oz /42.5 g

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Product Overview

Product Overview

GlyDerm Cream Plus 12% helps reveal youthful skin.

Achieve maximum resurfacing results with GlyDerm Cream Plus 12%. As the most potent cream in the GlyDerm lineup, this formula is ideal for those with mature or severely dry skin. It contains 12% glycolic acid, a powerful sugarcane derivative, plus salicylic acid, to exfoliate skin and clear pores. This helps to minimize redness and discoloration and smooth away rough patches. In addition to being one of the best exfoliators on the market, glycolic acid helps to reduce the appearance of signs of aging, such as fine lines and wrinkles, and stimulate healthy collagen production. It also works to increase overall hydration and moisture retention.

• Ideal for mature or very dry skin

• Exfoliates with salicylic acid and 12% glycolic acid

• Stimulates healthy collagen growth

Say goodbye to rough, tired skin with GlyDerm Cream Plus 12%.


  • Softens roughness
  • Exfoliates with glycolic acid
  • Stimulates collagen synthesis

Customer Reviews

Customer Reviews

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Overall Rating


Based on 6 reviews
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Verified Purchase

August 27, 2020

Glyderm cream 12%

I’ve used this for years and love it

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Verified Purchase

April 03, 2020

A real workhorse!

I use other Glyderm products (cleanser, face lotion 5, face lotion 10) and thought I’d advance to this one. Used sparingly and only at night this cream both hydrates and exfoliates. Begin with the gentler creams or lotions and move up to this when you can tolerate the increased glycolic acid content. Glycolic acid helps to build collagen, and is a good addition to a regimen which already includes vitamin C serum, sunscreen and retinol.

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LovelySkin Customer

Verified Purchase

August 10, 2017

Glyderm 12%

I purchased this in attempt to replace my md formulations glycolic acid night cream that was discontinued. I like this even better!

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Verified Purchase

May 09, 2017

Works well

This works really well on my dry skin. A little goes a long way and I do feel some stinging when I first apply it, but then it goes away. I feel I have seen an improvement in my skin. I do switch this out with my retinol.

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LovelySkin Customer

Verified Purchase

March 21, 2017

Glyderm 12

Great product to be used with caution. You should always start out with a lower dose #5 or #10 I believe. It does work well and should only be used at night. I use it as a exfoliator every so often.

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LovelySkin Customer

Verified Purchase

December 29, 2012

Great nighttime exfoliator

I've been using Glyderm products for over 15 years, since I first purchased them in my dermatologist's office. Glyderm Cream Plus 12% has been one of my staples. I do switch between a retinole product and this for my night "treatment", and probably use this more often of the two. The price is affordable; and, a little goes a long way. I am 60 and live in a high altitude, dry environment where I spend a good deal of time outdoors. The hydration delivered by this product is enough that I never wake up feeling dried out by the glycolic acid ingredients. Meanwhile, this product has helped ensure that my skin has never developed a less-than-new feeling or look inspite of the years which relentlessly keeping adding up!

Shipping & Returns

Shipping & Returns

Free U.S. Shipping. Period. View Our Shipping Policy

Return Policy: This product is non-returnable

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Special Shipping Requirements: ORM-D Class
ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In Stock.

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