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iS CLINICAL Hydra-Cool Serum  

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Product Overview

Product Overview

iS CLINICAL Hydra Cool Serum provides dry, damaged skin with essential hydration.

This cool, refreshing moisturizer provides the complexion with intense hydration, calming and soothing for dry, rosacea-prone or sunburned skin. This skin serum has optimal antioxidant benefits to nourish the complexion. It can also be used to calm mild acne symptoms or help with post-procedural healing. Your skin will feel soothed and refreshed with continued use of this hydrating serum.

This skin serum is formulated with ingredients to provide your complexion with essential antioxidant benefits.

Ideal for damaged, dry skin, this serum’s advanced formula contains powerful ingredients clinically proven to nourish your complexion. Its key ingredient, Centella Asiatica, is a botanical complex high in antioxidant benefits that heals and protects the skin. Hyaluronic acid binds essential moisture to the skin, rehydrating your dry complexion. These beneficial ingredients calm redness from rosacea and sunburns, leaving your complexion feeling soothed and renewed.


  • Calms irritation
  • Reduces acne symptoms
  • Increases hydration

Customer Reviews

Customer Reviews

Tell us your thoughts about iS CLINICAL Hydra-Cool Serum and receive 50 rewards points!

Overall Rating

Based on 88 reviews
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LovelySkin Customer

Verified Purchase

January 26, 2021


I love how this product is so easy and lightweight. I had been using a heavier HA and recently switched over to the iS Clinical line and I’m very happy. I use am and pm.

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Verified Purchase

January 15, 2021

This is a great skin calming product

I've used this serum for years and it definitely helps calm down redness in my cheeks +. It's my base layer every day.

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Verified Purchase

January 13, 2021

Keeps skin hydrated

I have combination skin that can get really oily or really dry depending on the weather or skin care routine. I love this serum because it hydrates your skin without getting greasy. I feel like I can add as much as I want without that greasy look.

Profile picture of EMK.


Verified Purchase

January 11, 2021

Soothing, Cooling Sensation

This is probably my 10th bottle of this stuff; it just WORKS. Hands down my favorite hydraulic serum. You instantly feel a cooling, soothing sensation when you put it on. I almost never skip a day with this serum, and layer it often with other iS Clinical serums. But it's also so good that sometimes wear it just on its own.

Profile picture of NRanner.


Verified Purchase

December 24, 2020

Beautiful, light hydrator

Beautiful product. Very lightweight, but effective. Just a little thicker than water, but it slides on so well that you only need to use 5-6 drops to cover your whole face. Love that it has a variety of ingredients in there too. Not your standard hydrating product.

Profile picture of Maki.


Verified Purchase

December 24, 2020

Hydra cool serum

My aesthetician switch up my skin care routine and I’m using iS Clinical products only now. And hydra serum is so perfect for me. My use to use SkinMedica HA5 but it would irritate my face. Hydra cool delivers! I just wish it came in a bigger bottle!

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LovelySkin Customer

Verified Purchase

December 12, 2020

Best serum

Because of the price, I tried other product but I always have to come back to this serum. This is a great serum for sensitive skin.

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Verified Purchase

November 21, 2020

My favorite serum

This serum provides quick absorbing moisture and is wonderful to mix with any iS Clinical serum to provide for improved absorption. Love this product and highly recommend.

Profile picture of Kay26.


Verified Purchase

November 13, 2020


This serum is hydrating and helps reduce redness. I'll definitely buy it again!

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Verified Purchase

November 08, 2020

Very nice

It has really helped with the healing of my acne as well as calming the inflammation and redness of existing acne. I am currently using topical meds and because of that, I find that on its own, it’s not hydrating enough and I definitely need to use a moisturizer after. But it has a nice cooling affect on the skin. I would recommend applying this on damp skin to allow it to penetrate better and then lock it with a good moisturizer.

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LovelySkin Customer

Verified Purchase

November 01, 2020

Favorite moisturizing serum

I was without this for a short while and began to notice creepiness on my cheeks. It diminished within a week of getting back on my routine - 2 x a day!

Profile picture of BunnyGirl.


Verified Purchase

October 24, 2020

Great serum with any vitamin c serum

I have very sensitive skin so most serums make my skin red. This serum is perfect to calm my red reaction. Now I can use the pro heal serum, which I love. The Hydra cool serum cools my skin after the pro heal. The two are a great combination.

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LovelySkin Customer

Verified Purchase

October 17, 2020

iS Hydra-cool Serum

Have used this product for over a year. The product goes on extremely smoothly alone or when combined with iS Genex-C or iSActive Serum. No sticky feeling after applying. After application, my skin has a nice feel and has helped maintain my skin's smoothness and texture. Don't let the price of this product put you off, as a very small amount of this product goes a long way, especially when combined with other products as noted above.

Profile picture of Metel.


Verified Purchase

October 16, 2020

slightly different from the sample I used

I really loved this when I tried the little sampler which my friend gave. I bought the same one but the cool feeling and aroma were way weaker than the one I used. Are there any changes to the formula? It is still Ok but not the best :(

Profile picture of Dyermaykker.


Verified Purchase

October 05, 2020

Pretty Good

I first received this as a sample and loved it. My skin was glowing. I then bought a bottle and thought it wasn't doing anything so I stopped using it and my skin became super dull. I couldn't believe the difference so I am back on using it daily in the morning. Super thin formula and it doesn't leave me sticky. Very mild smell. I like it.

Profile picture of Frenchthings.


Verified Purchase

October 02, 2020

Great enhancement to tinted sunscreen

Really enhances the application and look of my tinted moisturizer. Love it.

Profile picture of MaryLH.


Verified Purchase

October 02, 2020

So Many Benefits, So Many Uses!

This has been a great addition to my skin care routine. I'm 60 years old and use it nightly for increased hydration. In the morning, I mix a couple of drops in my liquid foundation. I read that tip from the original sample card. About a week ago, I had a Fraxel Dual treatment and found the Hydra-Cool Serum very helpful with healing!

Profile picture of lmsarbach.


Verified Purchase

September 17, 2020

First Time Trying This Serum

A water-based serum that hydrates, calms, soothes and cools skin, and provides antioxidant protection. It also keeps any adult acne in check. I only use this twice a week and do not have any issues with acne.

Profile picture of ER.


Verified Purchase

September 07, 2020

Not Sure

I’ve been using for 2 weeks and haven’t seen much difference. Will continue to use each night until bottle is gone.

Profile picture of Colourful.


Verified Purchase

September 05, 2020

Good Product

I tried a sample of this product from the IS Clinical travel size / starter kit and ended up buying the full size product. It's pretty good-- but doesn't seem like there's anything super exceptional about it. It's a nice HA serum to use as a base before moisturizer. I'm not sure if it's completely worth the cost though, as there may be other similar products for much less expensive.

Shipping & Returns

Shipping & Returns

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Return Policy: This product is non-returnable

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Special Shipping Requirements: ORM-D Class
ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: Depends on selected option.

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