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iS CLINICAL Hydra-Cool Serum

 
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$108.00

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Highlights
  • Calms irritation
  • Reduces acne symptoms
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Product Overview

iS CLINICAL Hydra-Cool Serum intensely hydrates, calms and soothes skin.

This cool, refreshing moisturizing serum provides intense hydration, calming and soothing benefits to dry, sensitized, rosacea-prone or sunburned skin. Formulated with antioxidant-rich Centella Asiatica, this serum provides protection against the aging effects of free radical damage while helping revitalize aging or compromised skin. 

Key Features:

  • Hyaluronic acid binds intense moisture to the surface of skin, plumping and smoothing fine lines
  • Vitamin B5 (pantothenic acid), helps restore damaged skin tissue
  • Ideal for all skin types, and is gentle enough for sensitive skin

Highlights

  • Calms irritation
  • Reduces acne symptoms
  • Increases hydration

Ingredients

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ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

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Product Specifications

About the Brand

Customer Reviews (209)

Overall Rating

4.7
Based on 209 reviews

Review Summary

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209 Reviews

Profile picture of Skin85258.

Skin85258

Verified Purchase

February 04, 2026

Perfect HA

This is the perfect HA serum. Absorbs in the skin nicely while being hydrating. Does not make products I put on top of pill either.

0 people found this helpful

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poreDecisions

Verified Purchase

January 09, 2026

Calms my skin faster than I calm myself

This serum is basically a chill pill for angry skin. Red, irritated, over-exfoliated, or just dramatic? Two pumps of Hydra-Cool and my face immediately stops filing formal complaints. It’s lightweight, sinks in fast, and doesn’t leave me shiny, sticky, or questioning my life choices. It layers beautifully under moisturizer, SPF, and actives — no pilling, no beef with retinol, no chaos. I especially love it post-treatment or on mornings when my skin wakes up choosing violence. That said… for the price, I did briefly expect it to pay my bills. The hydration is excellent but not long-lasting on its own, so you will still need a moisturizer unless you live in a rainforest or have naturally unproblematic skin (couldn’t be me). Why four stars? Because it’s amazing at calming and cooling, but it’s a supporting character, not the main hydration star. Incredible vibes, just not a one-product routine. Best for: sensitive or reactive skin, redness, post-procedure care, and people who like their skincare effective but not dramatic. Would I repurchase? Yes — while side-eyeing the price the entire time.

2 people found this helpful

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PalomaMia

from South Dakota

Normal Skin

Verified Purchase

December 26, 2025

Love this!

I have been using this serum for several years and I love it. Its the perfect light, hydrating, soothing and cooling serum. It truly does everything it promises to do! And I love the blue bottle. I would highy recommend this serum.

2 people found this helpful

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MissG

Verified Purchase

August 08, 2025

Leaves skin soft

This product leaves my skin soft. A little goes a long way.

2 people found this helpful

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JMP

from Florida

Oily Skin

Verified Purchase

July 26, 2025

Really Like

I got the sample size first and like it so much I purchased the full size. It hydrates my skin without making it feel greasy. I have sensitive, acne prone skin. This product works well for my difficult skin.

0 people found this helpful

Profile picture of TWood.

TWood

Verified Purchase

July 08, 2025

Soothing

I love this product, I use it twice a day and see the results dramatically when I use this product consistently. I can also see immediately when I don’t use the product. This leaves my skin feeling soothed and smoothed.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

May 01, 2025

The best

Hands down the best hydrating serum on the market. Cooling, lays well under makeup and other serums, perfect for my type 2 rosacea.

1 person found this helpful

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LovelySkin Customer

Verified Purchase

April 22, 2025

Love this

Love the IS Clinical line. Been using it a year recommended by my dermatologist and do see a difference.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

April 21, 2025

Favorite serum, just expensive

I love love love this serum, I just wish it was not so expensive. Otherwise it would be the only serum I ever use.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

April 15, 2025

Refreshing, gentle, hydrating serum

This serum glides on my skin and feels super refreshing. I use it before a night moisturizer when my skin is feeling extra dry and in the morning layered over the pro heal serum. It feels very smooth on my sensitive skin and doesn’t cause any irritation.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

March 11, 2025

Works well with cooling my face

When my spots flare up burning and itchy. I use this product and mix one of it's companion serums they have 2 . I use both one day and one night. They have helped me a lot. I will continue to buy them

1 person found this helpful

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connieb

Verified Purchase

March 11, 2025

hydra cool

this is the best product if you have any kind of procedure done that includes laser or heat, it cools the skin and helps the dryness while your skin recovers. love it wont be without it

0 people found this helpful

Profile picture of Bowie.

Bowie

Verified Purchase

February 20, 2025

Favorite product

I’ve been using for over a year now. I can’t believe the results

0 people found this helpful

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LovelySkin Customer

Verified Purchase

December 20, 2024

Absorbs quickly

Nice serum that absorbs quickly and doesn’t leave your skin feeling oily or dry, just smooth and plumped when used with the is clinical reparative moisture emulsion.

1 person found this helpful

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LovelySkin Customer

Verified Purchase

November 21, 2024

Dehyrate

The Hydra-Cool serum feels so good on my face. It definitely helps with my dry skin. I’ve become addicted to this stuff!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

October 05, 2024

Just OK

I purchased this thinking it will really hydrate my skin. I don’t feel like it hydrates as much as I expected. Perhaps it is because the menthol in it? I have been using it for about 3 weeks now. I don’t think I will repurchase this.

0 people found this helpful

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Diana445

Verified Purchase

October 03, 2024

Wonderful

This is a great product. I had been searching for a serum that wouldn't make me breakout or cause redness. My skin is super sensitive. This is the one. My skin has smoothed, evened and glows. People who have not seen me for a while , commented on how youthful I look, and me with gray hair. They tell me I look 40/45. I am 67! Thank you iS clinical!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

October 02, 2024

Great product

I received a sample of this on my previous order from the lovely skin , I was using skin pro health serum which is my number one serum recently added this one to my routine care which I love that too .highly recommended too

0 people found this helpful

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LovelySkin Customer

Verified Purchase

July 28, 2024

Hmmm

This felt nice and cooling initially but I’m not sure if it actually helped hydrate my skin more. Probably won’t repurchase but it was nice to use!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

July 22, 2024

Soothing

Recommended by my aesthetician, IS CLINICAL Hydra-Cool Serum is just that. I use it in the evening to prep my skin for retinoid application. My skin used to feel dry and tight as a result, but now it feels smooth and silky.

0 people found this helpful

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