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iS CLINICAL Super Serum Advance+

 
| HSA|FSA Eligible
$177.00

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Highlights
  • Increases collagen production
  • Increases collagen production
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Product Overview

iS CLINICAL Super Serum Advance+ brightens and improves signs of aging with advanced ingredients.

This effective anti-wrinkle treatment serum takes a multifaceted approach and targets wrinkles, dark spots and the look of hypertrophic scarring, while preventing future damage. Made with a powerful blend of high-quality ingredients, this serum uses 15% L-ascorbic acid to protect and correct signs of aging while copper tripeptide growth factors reduce wrinkles and maximize the effectiveness of other ingredients.

Key Features:

  • Centella Asiatica (gotu kola) provides powerful antioxidant protection
  • Arutin and musroom extract brightens the look of dark spots
  • Provides support against environmental factors

Highlights

  • Increases collagen production
  • Increases collagen production
  • Reduces fine lines and wrinkles

Ingredients

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ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

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Product Specifications

About the Brand

Customer Reviews (141)

Overall Rating

4.6
Based on 141 reviews

Review Summary

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141 Reviews

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LovelySkin Customer

from Florida

Age Group: 40-49

Verified Purchase

January 27, 2026

IS Clinical is the holy grail!

I have used the IS Clinical Active Serum for almost 20 years and wanted to add this to help with uneven skin tone and dark spots as I approach my late 40s. Wow! Within a week a few of the spots were noticeably lighter, and barely a month later they have almost disappeared. I use this at night and the active serum in the morning, IS Clinical Cleansing Complex twice a day, and the IS Clinical Moisturizing Complex twice a day. Yes, these are pricey, but you don't need to use a lot of product, so the bottles will last a while. And they WORK!!! You get what you pay for.

0 people found this helpful

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LovelySkin Customer

from Illinois

Age Group: 70-79

Mature Skin

Verified Purchase

January 03, 2026

Fantastic vitamin C product

I have repeatedly ordered iS CLINICAL Super Serum Advance+ because it has proven to provide a noticeable brightening to my skin. I stopped using it consistently a few months ago because I was trying to integrate different products into my routine, but came back to using it and saw almost immediate brightening soon after. For me, this is a holy grail product, and I would recommend it to anyone wanting to brighten and give their skin a glow.

0 people found this helpful

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KittyGirl

from California

Age Group: 60-69

Mature Skin

Verified Purchase

December 28, 2025

Love it

Those product gives me a nice glow and helps keep my moisturized all day. I have sensitive skin, but this does not bother me and seems to be effective.

0 people found this helpful

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Diana445

from Oregon

Age Group: 30-39

Wavy hair, Damage & split ends

Combination Skin

Verified Purchase

December 16, 2025

Brighter, Firmer, and Youthful Skin

I absolutely love the iS CLINICAL Super Serum Advance+! It has transformed my skin—fine lines and uneven texture are visibly improved, and my complexion looks brighter and more radiant. The serum absorbs quickly and feels lightweight, yet delivers powerful anti-aging benefits. My skin feels firmer, smoother, and healthier after regular use. Highly recommend for anyone looking to target signs of aging and boost overall skin radiance.

0 people found this helpful

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Apollosmom

from California

Age Group: 70-79

Wavy, Color treated hair

Mature Skin

Verified Purchase

November 05, 2025

The best vitamin C serum for me!

I have been using this vitamin C serum for at least a few years, if not more, now. This was the first VC serum my skin did not react badly, and I also like the way it brightens my skin. I try buying it on sale and having a stock enough to last for at least several months.

0 people found this helpful

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Suzzz

Verified Purchase

June 10, 2025

Very Nice!

I usually use iS Clinical Healing Serum so I thought I'd try this for a change. I like it and would buy again.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

January 08, 2025

More than just a Vit C Serum

I’ve never stayed faithful to a single vitamin C serum, even THAT famous one. I was about to give up on them completely, thinking my skin simply didn’t respond as well as others to the vitamin’s brightening effects. However, the ingredient list on this Super Advanced Plus serum is just so impressive! More skin brightening ingredients than any other brand, and a blend peptides to boot. So far, I have seen a gradual brightening of sun damage and an overall boost in radiance. I expect to see more results with continued use. So happy to have easy access to the serum at a great price here on LovelySkin.

1 person found this helpful

Profile picture of AnJB.

AnJB

Verified Purchase

December 31, 2024

My Face Is Brighter

I have tried many products in my search for the perfect anti-aging skin care. Lots of broken promises from high and moderately priced serums, potions and lotions. I've been using this Super Serum Advance + for about 3 weeks and I do believe my skin looks brighter and more even toned that before. Many years ago I was a sun worshipper and though it felt so good back then, those age spots and uneven skin tone are not easy to reverse. Once daily use of this serum at night, under a very emollient hydrating cream has really made a difference in just a few weeks. I tried using in in the morning under makeup but it definitely pills for me. So even just using it once a day has shown some improvement for me, and I'm hopeful that as I keep using it, my skin will look even better! This is not an inexpensive product but it looks like it will last at least 3-4 months if I use it once a day so I feel the cost is worth it if it makes my skin look bright and even! Try it yourself and see!

0 people found this helpful

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SamGar

Verified Purchase

September 01, 2024

Excellent Product

This serum is quite effective.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

August 06, 2024

So far so good

Smells neutral. Goes on easily. No irritation. Haven't used long enough, so still waiting to see results.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

July 28, 2024

Nah

This irritated my skin and caused breakouts for me. I do have acne prone skin though so I still think it’s worth trying. Texture and application was nice.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

May 31, 2024

Is Clinical Super Serum Advanced

I’ve been using the super serum advanced for a few years now and have been very pleased with the results. I don’t have to worry about dark spots from sun exposure (and I spend a lot of time in the sun). This was recommended for me by the esthetician at my dermatologist’s office.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

March 09, 2024

Alternative to the other brand

So far I am really loving it! I notice a slight stinging to my face vs the other major name brand that starts with an S. This tells me it is more concentrated. Also like that it helps with collagen synthesis and has other actives. My skin is brighter for sure. Still halfway on my first bottle. Will probably re-order.

0 people found this helpful

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BrandyD

Verified Purchase

March 07, 2024

My holy grail serum!

I have repurchased this serum over and over and over again! My previous esthetician used it on me and recommended it and I have been hooked since! I truly notice a difference when I run out! Will forever rebuy!!

1 person found this helpful

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LovelySkin Customer

Verified Purchase

February 28, 2024

Superior Vitamin C serum

I’ve tried several vitamin C serums including the Pro Heal, and this has been the best one by far. I have sensitive, acne prone, combination skin, and this serum did not cause any adverse reactions as other vitamin c serums have. After one month of use, I can see lightening of my hyperpigmentation and overall brightening of my skin. I took away one star because the product does sting when first applied to my skin, but it dissipates quickly.

2 people found this helpful

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Hawkscout1

Verified Purchase

January 17, 2024

Nice Serum but super thin.

I think I am seeing results after using it for about a month. I do not have bad issues with my skin and have used several of their products. It is super thin so you have to be careful when applying it.

0 people found this helpful

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Hdhd

Verified Purchase

December 19, 2023

The best!!!

I am a product junkie and have tried every vit C product on the market …this one is by far the best!!!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

December 06, 2023

Good serum

I was between this and the Pro-heal that I normally purchase. This was good but next time I'll good back to the Pro-heal because it keeps my skin a little more clear.

0 people found this helpful

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nyxsl

Verified Purchase

December 02, 2023

The best vitamin C serum

Saw wonderful reviews about this product so I decided to pick it up during the holiday sale.. my favorite new vitamin C serum. The texture is very thin and absorbs right into my skin. Not to mention the copper peptides/other beneficial skin ingredients. Definitely a winner. I picked up the smaller size because I wasn't sure how my skin would react to it as I have very sensitive skin but this is product is so gentle.. will pick up the larger size when I'm finished. Also like the dropper on this product, makes it easy to use.

1 person found this helpful

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LovelySkin Customer

Verified Purchase

October 21, 2023

Soft skin

Softer brighter skin with no irritation. Love it! Sunscreen and makeup layer nicely on top

0 people found this helpful

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