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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$150.00
Highlights
  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream targets deep-set wrinkles with injection-inspired technology.

This advanced peptide cream harnesses patented technology to address the static, deep-set lines that neurotoxin injections alone can't fully correct. 10% MYRIXIN and an anti-wrinkle peptide support a smoother feel while niacinamide, LHA and zinc PCA reveal greater radiance. Tested by physicians, this cream can either enhance your neurotoxin results or stand on its own as a pillar of your anti-aging regimen.

Clinical Results:

  • Hydration is boosted by 94% in just one hour and provides 24-hour hydration
  • Sebum accumulation is reduced by 50% after 8 hours vs untreated skin
  • Wrinkles are visibly reduced by up to 33% after 12 weeks
  • Pore size is reduced by up to 30% after 12 weeks
  • Seven skin quality parameters are visibly improved including skin tone evenness (up to 30%) after 12 weeks

Key Features:

  • Ideal for men and women seeking refined texture and clarity
  • Enhances the results of in-office neurotoxin injections to visibly reduce wrinkles
  • Brings out a glass-skin appearance in just 1 week when used with P-TIOX Serum

Highlights

  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

Ingredients

Directions

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Product Specifications

About the Brand

Customer Reviews (53)

Overall Rating

4.6
Based on 53 reviews

Review Summary

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53 Reviews

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LovelySkin Customer

from California

Age Group: 80+

Curly Hair

Normal Skin

Verified Purchase

August 14, 2026

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

The sample of the cream felt really good on my skin and noticed my skin looked better. I immediately ordered the cream. I am in my 80's and this cream made my skin look even better. I have not had any chemical or laser peel to my skin and rely on good products to make my skin look and feel good. I am very happy with this cream.

0 people found this helpful

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Spasmith

from Colorado

Verified Purchase

August 13, 2026

Moisturizing and cooling

I love the consistency of the product and it keeps my skin hydrated through the night.

0 people found this helpful

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Bevdog

from New Mexico

Age Group: 60-69

Verified Purchase

August 13, 2026

ideal for mature skin

I really like the lightweight feel of PTOX cream. I have not necessarily seen results but I'm encouraged by the feel of my skin.

0 people found this helpful

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pzg

from Idaho

Age Group: 70-79

Mature Skin

Verified Purchase

August 13, 2026

Amazing!

What a nice surprise. Thank you LovelySkin for the sample! My skin is always changing during the seasons. I'm 75! I took a chance on this and boy am I glad I did. The hydration is perfect! My pores seem to calm down. My Rosacea is calmer. Lines seem to soften! Perfect! This is a keeper!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

August 13, 2026

3Goldengirls

NICE PRODUCT- SINKS INTO SKIN-NOT GREASY-NICE UNDER SKIN CEUTICALS TINTED SPF.WOULD PROBABLY USE THICKER CREAM AT NIGHT, BUT DEFINITELY LIKE THIS PRODUCT.

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

August 08, 2026

Great Day Time Moisturizer

I love this cream. It is light enough to use under my moisturizing sunscreen, but it is effective enough to moisturize and keep my skin wrinkle-free, and I have actually seen a decrease in oil buildup around my nose and chin area. I use the serum as well, and the two together will keep my 63-year-old skin looking like I am in my 40's :). Thank you, SkinCeuticals, for NOT putting fragrance in this product.

0 people found this helpful

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VA

from Illinois

Age Group: 70-79

Mature Skin

Verified Purchase

August 07, 2026

P-TIOX

Since turning 70, I am dealing with a loss of volume around the corners of my mouth (not nasal labial folds, more around my lower palate). In addition to this disappointing development, my chin seems to be taking on an "orange peel" appearance. YIKES! I just started using this for pore correction on the chin and help with the lines at the corners of my mouth. I feel like sticking cotton balls in this area (like Marlon Brando in The Godfather). I love how the product feels; the texture of the cream is truly wonderful. I don't know yet whether it will help much with the truly scary areas of my face but the parts of face that haven't gone to pot do look better since I started using this cream. Still, I'm hoping for help with the chin and mouth corners and do not want to end up with a Joker mouth so I will not consider injectables, fillers, etc. I figure my jaw is receding and I probably am experiencing some bone loss is this area. Oh well.

2 people found this helpful

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Enmy

Age Group: 70-79

Mature Skin

Verified Purchase

August 04, 2026

Looking younger

I am a 70+ year old female with a devoted practice to using Skinceutical products. Prior to using P-Tiox i had used the Triple Lipid formula for a couple of years. I could see a visible difference in skin looking softer and less wrinkly with P-Tiox just after 2 weeks so i will stick with the P-Tiox formula. It also goes on very smoothly and absorbs quickly into my dry skin.

1 person found this helpful

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EPyer

from Tennessee

Age Group: 70-79

Verified Purchase

August 03, 2026

P-Tiox peptide cream

Just started using it but combined with P-Tiox Serum it definitely seems to be helping slight wrinkles. Time will tell.

1 person found this helpful

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LovelySkin Customer

from Louisiana

Age Group: 50-59

Straight Hair

Combination Skin

Verified Purchase

August 01, 2026

Favorite by far!!

I’m very satisfied with this product.

2 people found this helpful

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LovelySkin Customer

from California

Age Group: 70-79

Combination Skin

Verified Purchase

July 30, 2026

P-TIOX Cream

I switched to P-TIOX from another Skinceuticals face cream for nighttime use on the advice of my facialist. She was right. It is light on the skin but very effective. I'm already seeing a difference after a month of using it, and I'm pretty sure I'll never go back to a typical heavy night cream again. It seems pretty amazing to me!

2 people found this helpful

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HappyGrandma

from Washington

Age Group: 80+

Mature Skin

Verified Purchase

July 29, 2026

P-TIOX CREAM

I’ve been using the P-TIOX serum so I am excited to see the results when I use these two products together. I trust SkinCeuticals products. This cream is lightweight and glides onto my skin. I will use it in the morning and a heavier cream in the evenings.

1 person found this helpful

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dhinca

from California

Verified Purchase

July 28, 2026

Beautiful feel

This cream has a lovely feel, but, since I use the P-TIOX serum, I am not sure I need it. My skin is quite dry, so even if I use this, I need to add a moisturizer.

1 person found this helpful

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LovelySkin Customer

from Puerto Rico

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

July 28, 2026

In Love!

My skin is loving this cream. Goes on smoothly and absorbs quickly. No greasy feeling at all. Using at night along with the serum. Only reason didn't give the 5 stars is that I want to wait couple of month and see what happens. So far, very happy on how my skin looks and feel.

2 people found this helpful

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Rainydayz

from Oregon

Age Group: 50-59

Verified Purchase

July 27, 2026

P-TIOX Peptide Cream

So far after two weeks, I think it’s a great addition to add alternating morning routine. I love that I can apply to eyes. Would purchase again!

1 person found this helpful

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HJ

from Virginia

Verified Purchase

July 27, 2026

might work for oily/combination skin

This cream has a very lightweight, almost gel-like consistency. Because I have dry skin, it just wasn't emollient enough to provide lasting hydration. However, it would likely work beautifully for anyone with oily or combination skin types.

1 person found this helpful

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LovelySkin Customer

from Colorado

Verified Purchase

July 24, 2026

P-TIOX

I really liked this product from the first time I used it. I use it every night before bedtime now to see if it makes a significant difference over time. My skin feels moist and soft. I live in a very arid climate so moisturizing is always a challenge!

1 person found this helpful

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Skinfocus

from Texas

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

July 18, 2026

Nice addition

I was skeptical about this creme at first but went ahead and tried it. About 2 weeks into using it and do see some results. Waiting for more change as the next several weeks pass. Not dramatic but gradual improvement in fine lines and wrinkles.

2 people found this helpful

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Ar

from North Carolina

Age Group: 70-79

Straight Hair

Mature Skin

Verified Purchase

July 16, 2026

Great product.

Great product. Goes on easily. Hoping for positive results

0 people found this helpful

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Dsb

from Pennsylvania

Age Group: 60-69

Wavy Hair

Oily Skin

Verified Purchase

July 16, 2026

Nice Edition

I like the cream very much. I had tried the serum and did not love the residual feeling on my skin. I very much like the feeling of the cream although I've only been using it at night. I've been using CE Ferulic for years and started on Ultra Serum. The P-tox cream with the other products really makes a difference to me. I actually do get comments on my skin at age 65 and have my sister, daughter and nieces on board.

2 people found this helpful

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