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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$150.00

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Highlights
  • Addresses deep static wrinkles
  • Smooths the look of skin texture

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream targets deep-set wrinkles with injection-inspired technology.

This advanced peptide cream harnesses patented technology to address the static, deep-set lines that neurotoxin injections alone can't fully correct. 10% MYRIXIN and an anti-wrinkle peptide support a smoother feel while niacinamide, LHA and zinc PCA reveal greater radiance. Tested by physicians, this cream can either enhance your neurotoxin results or stand on its own as a pillar of your anti-aging regimen.

Clinical Results:

  • Hydration is boosted by 94% in just one hour and provides 24-hour hydration
  • Sebum accumulation is reduced by 50% after 8 hours vs untreated skin
  • Wrinkles are visibly reduced by up to 33% after 12 weeks
  • Pore size is reduced by up to 30% after 12 weeks
  • Seven skin quality parameters are visibly improved including skin tone evenness (up to 30%) after 12 weeks

Key Features:

  • Ideal for men and women seeking refined texture and clarity
  • Enhances the results of in-office neurotoxin injections to visibly reduce wrinkles
  • Brings out a glass-skin appearance in just 1 week when used with P-TIOX Serum

Highlights

  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

Ingredients

Directions

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ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! . Ships within the U.S. only.

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Product Specifications

About the Brand

Customer Reviews (78)

Overall Rating

4.6
Based on 78 reviews

Review Summary

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78 Reviews

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LovelySkin Customer

from Arizona

Verified Purchase

September 26, 2026

Beautiful results

I am so surprised at how nice this cream is, especially when used with the serum. It goes on smoothly and leaves my skin glowing. Makeup just glides on and the glow shines through!

0 people found this helpful

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4bikes

from North Carolina

Age Group: 40-49

Straight Hair

Normal Skin

Verified Purchase

September 25, 2026

Very hydrating!

This product does a great job hydrating the skin, and it does soften fine lines. I bought it to help Botox last longer. I think it is doing that and this is my second jar.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

September 25, 2026

It’s ok, nothing too noticeable

It doesn’t bother or irritate my sensitive skin. However I did not notice some noticeable “ wrinkle modulation “ . Just a good enough moisturizer which might not be enough for dry skin, especially in cold climates.

0 people found this helpful

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LovelySkin Customer

from California

Verified Purchase

September 24, 2026

Skin care

I love this peptide cream. I pair it with the serum, and it great. Also very nice as a moisturizer. My esthetician had recommended this, and pairing this with the serum leaves my skin looking so healthy and it simply glows. I would absolutely recommend.

0 people found this helpful

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Lgugliel

from Tennessee

Age Group: 40-49

Wavy, Color treated hair

Combination Skin

Verified Purchase

September 22, 2026

Amazing moisturizer!

Holy grail product! I can’t believe how much this products hydrates and refines skin texture! My skin has never look better.

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 50-59

Combination Skin

Verified Purchase

September 22, 2026

Will buy again

Been using for a month, my face looks slightly brighter, hydrated ( not much difference on wrinkles ) i will purchase again to see if lines around my eyes improve. Not greasy.

0 people found this helpful

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Renzy

from Pennsylvania

Age Group: 50-59

Mature Skin

Verified Purchase

September 19, 2026

Great cream

Love this peptide cream. Minimizes fine lines and wrinkles and smooths skin

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 70-79

Mature Skin

Verified Purchase

September 19, 2026

Moisturizing

It seems to be very hydrating. Leaves my skin with a dewy appearance. Haven’t used it long enough to comment on long term benefits.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

September 18, 2026

SkinCeuticals P-TIOX Peptide Cream

I had been using the serum and received a cream sample in the mail. I have found that the cream really made a difference in my skin appearance. If I could afford both I would use both but at this price I can only afford one and the cream works better for me. I would definitely recommend.

0 people found this helpful

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LAnnO

from Texas

Age Group: 50-59

Dry Skin

Verified Purchase

September 17, 2026

P-Tox

Thought I would like this more.

0 people found this helpful

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JuW

Verified Purchase

September 16, 2026

Love this new face cream

The texture is very pleasant to apply. It is light and silky. It really makes the pores smaller and the skin looks more even. I love this new face cream.

0 people found this helpful

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MargaretMarie

from Michigan

Age Group: 30-39

Normal Skin

Verified Purchase

September 16, 2026

My everyday lotion

It is the perfect weight! If you like the ptox serum, you’ll love the lotion. Great for makeup prep as well

0 people found this helpful

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Peachie

from Georgia

Age Group: 70-79

Curly Hair

Dry Skin

Verified Purchase

September 12, 2026

Best yet

I have seen a noticeable improvement in texture and cone of my skin using both P-tiox serum and the new cream. It goes in like a dream and doesn't feel greasy. I am even using it around my eyes with to allergic reaction and no puffiness. I love this stuff.

1 person found this helpful

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LovelySkin Customer

from Florida

Age Group: 70-79

Straight Hair

Mature Skin

Verified Purchase

September 12, 2026

P-TIOX

Love, Love this cream! It is light and absorbs very well - suitable for daytime use. I also use this cream at night over serum. Happy with the appearance of my skin. P-TIOX also works well in a humid climate

1 person found this helpful

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author

from Indiana

Age Group: 70-79

Mature Skin

Verified Purchase

September 11, 2026

A POWER HOUSE!

This product is amazing! I love that it can be used ALL over the face. I'm delighted to say I notice an improvement in skin around my eyes.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

September 05, 2026

Wow!!

I love the PTIOX serum, so when I saw they had a cream, I jumped on it and I'm so glad that I did! Amazing!! My skin feels great and looks great! I can see the difference in fine lines and overall appearance. Love!

1 person found this helpful

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sandytp1

from Iowa

Verified Purchase

September 02, 2026

Not moisturizing enough

I didn't think this was moisturizing enough for my dry skin. I really wanted to love it as it was rated the top firming moisturizer by InStyle.

0 people found this helpful

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LovelySkin Customer

from Oregon

Age Group: 60-69

Straight, Color treated hair

Dry Skin

Verified Purchase

September 02, 2026

Great product

I love the way this cream feels. It is so silky. It's makes my skin feel instantly soft and has really brightened my skin. Fine wrinkles are less noticeable too.

1 person found this helpful

Profile picture of AbbyB19.

AbbyB19

from Michigan

Verified Purchase

August 31, 2026

Immediate keeper

I initially found out about this product from lovely skin via the free sample sent . I respect the quality of skinceuticals products but wasn’t aware of this one. It was a nice surprise. My skin’s appearance was immediately smoother and more luminous. It’s a perfect base for the tinted sunscreen I use. I immediately ordered a full size product and will continue to do so.

0 people found this helpful

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AMIGAL

from Florida

Age Group: 50-59

Combination Skin

Verified Purchase

August 27, 2026

Peptides are all the rage...

...so I was pleased to get a sample in my last order. Loved it and purchased a full size. This cream is dreamy going on: light and sinks right in. Very pleased with the results it is having on my skin. I'll be re-ordering this for sure.

0 people found this helpful

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