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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$150.00
Highlights
  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream targets deep-set wrinkles with injection-inspired technology.

This advanced peptide cream harnesses patented technology to address the static, deep-set lines that neurotoxin injections alone can't fully correct. 10% MYRIXIN and an anti-wrinkle peptide support a smoother feel while niacinamide, LHA and zinc PCA reveal greater radiance. Tested by physicians, this cream can either enhance your neurotoxin results or stand on its own as a pillar of your anti-aging regimen.

Clinical Results:

  • Hydration is boosted by 94% in just one hour and provides 24-hour hydration
  • Sebum accumulation is reduced by 50% after 8 hours vs untreated skin
  • Wrinkles are visibly reduced by up to 33% after 12 weeks
  • Pore size is reduced by up to 30% after 12 weeks
  • Seven skin quality parameters are visibly improved including skin tone evenness (up to 30%) after 12 weeks

Key Features:

  • Ideal for men and women seeking refined texture and clarity
  • Enhances the results of in-office neurotoxin injections to visibly reduce wrinkles
  • Brings out a glass-skin appearance in just 1 week when used with P-TIOX Serum

Highlights

  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

Ingredients

Directions

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Product Specifications

About the Brand

Customer Reviews (20)

Overall Rating

4.8
Based on 20 reviews

Review Summary

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20 Reviews

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LovelySkin Customer

from California

Age Group: 40-49

Dry Skin

Verified Purchase

June 17, 2026

My new favorite moisturizer

I love skin ceuticals and was provide a sample of this by my dermatologist. It works so well with P-tiox serum (great without also). My skin feels moisturized and complexion prettier. I’m 49, sensitive, dry skin, this feels so good on my skin.

0 people found this helpful

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Karka

from Pennsylvania

Age Group: 60-69

Curly, Dry Hair

Combination Skin

Verified Purchase

June 13, 2026

It works!

I love it. I noticed more glowy skin and my pores are smaller. Will continue to use.

0 people found this helpful

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AZDeb

Verified Purchase

June 09, 2026

Feels amazing!

It’s probably a bit too early to talk about results but I absolutely love the way this feels going on my skin. And a tiny bit goes a very long way. It feels cool and refreshing and luscious. If it’s anything like the P-TIOX serum then I’ll enjoy the benefits after a bit of time.

2 people found this helpful

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TCQ

from Texas

Mature Skin

Verified Purchase

June 09, 2026

Skin-Ceuticals Miracle Product

I was already using the P-TIOX serum & loving it. I was extremely looking forward to the Wrinkle Modulating Peptide Cream. This product does not disappoint. It glides on so easily & leaves my skin with such a beautiful satin finish. I use it morning & at night. Fabulous product to add to your skin routine.

1 person found this helpful

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LovelySkin Customer

from Illinois

Age Group: 50-59

Normal Skin

Verified Purchase

June 08, 2026

This works

Only been a few months, but I can see results. My fine lines around my mouth look much smoother.

2 people found this helpful

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KishaC

from Georgia

Age Group: 40-49

Straight, Color treated hair

Normal Skin

Verified Purchase

June 04, 2026

Excellent Night Cream!

I have been using SkinCeuticals products for over 10 years. This cream is a perfect complement to my nightly Retinol regimen. My skin looks amazing when I wake up! Supple and glowing!

1 person found this helpful

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OHinNE

from Nebraska

Age Group: 60-69

Straight Hair

Normal Skin

Verified Purchase

June 04, 2026

Silky and Smooth

Although I have used this only for a few weeks, this product goes on silky and makes the skin feel smooth! I feel I have noticed a softening of my laugh lines. I cannot wait to see what the result will look like with continued use!

1 person found this helpful

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Chris263

from Massachusetts

Age Group: 60-69

Mature Skin

Verified Purchase

June 02, 2026

Feels great !

I’ve always used triple lipid for years and then I decided to give this product to try. It feels different. It makes your skin so soft. I absolutely love it, but I will switch back-and-forth with the triple lipid and this

3 people found this helpful

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LovelySkin Customer

from Puerto Rico

Age Group: 30-39

Wavy, Color treated hair

Dry Skin

Verified Purchase

June 02, 2026

The best of the best

Amazing. I wouldn’t change a thing of this product totally in love.

0 people found this helpful

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BethAnn

from Wisconsin

Age Group: 50-59

Verified Purchase

June 01, 2026

Awesome addition to my routine

I love this new product. It’s so fine and lightweight. Smooth application and soaks into my skin. My friend ask what I was doing different and I told her about this new product. She purchased as we were speaking

1 person found this helpful

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LindyMU

Verified Purchase

June 01, 2026

The BEST SkinCeuticals product!

I use many SkinCeuticals products but hands down, the P-TIOX cream is the best! It leaves your face so soft and smooth. I love it!

0 people found this helpful

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Ilap

from New York

Age Group: 40-49

Verified Purchase

June 01, 2026

Wow no more pores

Wow this is amazing, I have been using this line for 30 years and products are great but this is unbelievable cream. Pores not that I had many, but the few that I had are not visible at all after just a few days. Glow skin smoother….great cream!

1 person found this helpful

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OlyLady

from Washington

Age Group: 70-79

Verified Purchase

May 30, 2026

P-TIOX review

I have been using P-TIOX about a month. I use it at night as a moisturizer. I LOVE the consistency. It spreads across my face easily and is absorbed immediately. It has a thinner consistency than most moisturizers and I really like that. I feel like it soaks into my skin rather getting rubbed off onto my pillow case. In the morning my wrinkles do seem somewhat diminished. I’ll be interested to see the long term results.

3 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 60-69

Verified Purchase

May 30, 2026

LOVE this cream!

SkinCeuticals has been my top go-to brand for years. I tried the P-TIOX Serum when it came out but wasn’t impressed. The P-TIOX Wrinkle Modulating Peptide Cream is a different matter! I have only been using it for 2 weeks and am already noticing results. Texture is my number one skin concern. In just 2 weeks my pores appear smaller and my overall skin appearance looks smoother. Amazing! I can’t wait to see if things continue to improve. Love this product!

2 people found this helpful

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LovelySkin Customer

from Arizona

Age Group: 70-79

Mature Skin

Verified Purchase

May 29, 2026

Too light for Mature Skin

A very light moisturizer. Makeup applies smoothly over it but not suitable for dry, mature skin. Will try the serum instead under my favorite Triple Lipid product.

4 people found this helpful

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Flowers

from New York

Age Group: 70-79

Verified Purchase

May 29, 2026

My skin glows

I love how flawless my skin looks.this is really an incredible product

1 person found this helpful

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MH20

from Rhode Island

Verified Purchase

May 28, 2026

P-TIOX CREAM

I love this cream! As a user of the P-TIOX Serum I was thrilled to see the compatible cream and it does not disappoint! I love the texture and level of moisture; the consistency is soothing and so nice to use.

2 people found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 60-69

Straight hair, Dry/flaky scalp

Dry Skin

Verified Purchase

May 18, 2026

Skin Ceuticals

Skin Ceutical brand products are the Holy Grail, and this product doesn't disappoint! P-TIOX works great in my areas that were sagging or looked wrinkled. A must-have for your skin care routine.

8 people found this helpful

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CharlieC

Verified Purchase

May 16, 2026

Love!

I use the p-tiox serum on areas where I have fine lines and I was so excited to see that Skinceuticals made a cream to compliment. I normally use the triple lipid repair or Alastin for my moisturizer and was hesitant due to my slightly sensitive skin. But with about 2-4 days of adjusting to the new cream and my face is comfortable and in love with this product. It feels a lot like the triple lipid repair but not as thick and it dries a lot quicker. It goes great under makeup too…. Stay tuned for long term results

8 people found this helpful

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mazz

from South Carolina

Age Group: 40-49

Normal Skin

Verified Purchase

May 08, 2026

So far so good

Keeping in mind it is too early to determine any long term impact to lines or pores, I can vouch for the moisturization aspect. It's not as rich of a moisturizer as their others (I'm an avid Lipid Restore user) but this lightweight formula absorbs well and definitely keeps the skin hydrated. The only reason I took a star off is the scent. The actual scent is somewhat off in my opinion, almost resembling a faint wet dog odor. Fortunately, it doesn't last but it was worth mentioning.

27 people found this helpful

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