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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$150.00
Highlights
  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream targets deep-set wrinkles with injection-inspired technology.

This advanced peptide cream harnesses patented technology to address the static, deep-set lines that neurotoxin injections alone can't fully correct. 10% MYRIXIN and an anti-wrinkle peptide support a smoother feel while niacinamide, LHA and zinc PCA reveal greater radiance. Tested by physicians, this cream can either enhance your neurotoxin results or stand on its own as a pillar of your anti-aging regimen.

Clinical Results:

  • Hydration is boosted by 94% in just one hour and provides 24-hour hydration
  • Sebum accumulation is reduced by 50% after 8 hours vs untreated skin
  • Wrinkles are visibly reduced by up to 33% after 12 weeks
  • Pore size is reduced by up to 30% after 12 weeks
  • Seven skin quality parameters are visibly improved including skin tone evenness (up to 30%) after 12 weeks

Key Features:

  • Ideal for men and women seeking refined texture and clarity
  • Enhances the results of in-office neurotoxin injections to visibly reduce wrinkles
  • Brings out a glass-skin appearance in just 1 week when used with P-TIOX Serum

Highlights

  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

Ingredients

Directions

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Product Specifications

About the Brand

Customer Reviews (43)

Overall Rating

4.6
Based on 43 reviews

Review Summary

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43 Reviews

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LovelySkin Customer

from California

Age Group: 70-79

Combination Skin

Verified Purchase

July 30, 2026

P-TIOX Cream

I switched to P-TIOX from another Skinceuticals face cream for nighttime use on the advice of my facialist. She was right. It is light on the skin but very effective. I'm already seeing a difference after a month of using it, and I'm pretty sure I'll never go back to a typical heavy night cream again. It seems pretty amazing to me!

1 person found this helpful

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HappyGrandma

from Washington

Age Group: 80+

Mature Skin

Verified Purchase

July 29, 2026

P-TIOX CREAM

I’ve been using the P-TIOX serum so I am excited to see the results when I use these two products together. I trust SkinCeuticals products. This cream is lightweight and glides onto my skin. I will use it in the morning and a heavier cream in the evenings.

0 people found this helpful

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dhinca

from California

Verified Purchase

July 28, 2026

Beautiful feel

This cream has a lovely feel, but, since I use the P-TIOX serum, I am not sure I need it. My skin is quite dry, so even if I use this, I need to add a moisturizer.

0 people found this helpful

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LovelySkin Customer

from Puerto Rico

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

July 28, 2026

In Love!

My skin is loving this cream. Goes on smoothly and absorbs quickly. No greasy feeling at all. Using at night along with the serum. Only reason didn't give the 5 stars is that I want to wait couple of month and see what happens. So far, very happy on how my skin looks and feel.

1 person found this helpful

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Rainydayz

from Oregon

Age Group: 50-59

Verified Purchase

July 27, 2026

P-TIOX Peptide Cream

So far after two weeks, I think it’s a great addition to add alternating morning routine. I love that I can apply to eyes. Would purchase again!

0 people found this helpful

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HJ

from Virginia

Verified Purchase

July 27, 2026

might work for oily/combination skin

This cream has a very lightweight, almost gel-like consistency. Because I have dry skin, it just wasn't emollient enough to provide lasting hydration. However, it would likely work beautifully for anyone with oily or combination skin types.

0 people found this helpful

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LovelySkin Customer

from Colorado

Verified Purchase

July 24, 2026

P-TIOX

I really liked this product from the first time I used it. I use it every night before bedtime now to see if it makes a significant difference over time. My skin feels moist and soft. I live in a very arid climate so moisturizing is always a challenge!

0 people found this helpful

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Skinfocus

from Texas

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

July 18, 2026

Nice addition

I was skeptical about this creme at first but went ahead and tried it. About 2 weeks into using it and do see some results. Waiting for more change as the next several weeks pass. Not dramatic but gradual improvement in fine lines and wrinkles.

1 person found this helpful

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Ar

from North Carolina

Age Group: 70-79

Straight Hair

Mature Skin

Verified Purchase

July 16, 2026

Great product.

Great product. Goes on easily. Hoping for positive results

0 people found this helpful

Profile picture of Dsb.

Dsb

from Pennsylvania

Age Group: 60-69

Wavy Hair

Oily Skin

Verified Purchase

July 16, 2026

Nice Edition

I like the cream very much. I had tried the serum and did not love the residual feeling on my skin. I very much like the feeling of the cream although I've only been using it at night. I've been using CE Ferulic for years and started on Ultra Serum. The P-tox cream with the other products really makes a difference to me. I actually do get comments on my skin at age 65 and have my sister, daughter and nieces on board.

2 people found this helpful

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EGG

from Texas

Age Group: 80+

Wavy, Color treated hair

Mature Skin

Verified Purchase

July 16, 2026

Great moisturizer

I was amazed at the glow this moisturizer provided. Judging from all the compliments I received I would definitely say this is a winner.

0 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 70-79

Wavy, Color treated hair

Mature Skin

Verified Purchase

July 14, 2026

It helps

I have used the serum and it has immediate visible effects, but it is a bit drying on my already dry skin. The cream is not as drying, but the effects are not as noticeable. However, I do think that using this may help delay Botox injections every few months. I will update my results in few months.

2 people found this helpful

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LovelySkin Customer

from California

Age Group: 40-49

Combination Skin

Verified Purchase

July 11, 2026

P-TIOX Cream

This is a great product. I typically use the serum and LOVE that product. This is a nice complement to my daytime routine.

0 people found this helpful

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Josephine

Verified Purchase

July 09, 2026

Skin Ceuticals P-Tiox Cream

Cream is amazing. Addressed deep wrinkles - may have clearly been reduced. My skin is very well hydrated and my pores have reduced in size. Love my skin tone - I definitely will continue to use.

1 person found this helpful

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Sunshine87

Verified Purchase

July 07, 2026

Wanted to love it…

Disappointed. I LOVE Skinceuticals P-TIOX serum, so I was hopeful about this cream. The serum feels great, and most importantly, works, but this cream did nothing. Won’t be repurchasing. Skinceuticals does the best serums, but I haven’t found a moisturizer of theirs that I like or feel works.

4 people found this helpful

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SYM

from South Carolina

Age Group: 60-69

Mature Skin

Verified Purchase

July 06, 2026

Different Cream

Feels really good when applying. Soaks into skn leaving a soft great feeling.

0 people found this helpful

Profile picture of Flyhi.

Flyhi

from Arizona

Age Group: 70-79

Verified Purchase

June 30, 2026

So far!

Have only used it for a few weeks but feels good on my skin and goes on easily. I like that this serum can be used around eyes also. Waiting for results!

0 people found this helpful

Profile picture of Teresa1955.

Teresa1955

from California

Age Group: 70-79

Verified Purchase

June 26, 2026

It’s feels like silk!

The perfect cream to help attain glass like skin, not greasy and absorbs quickly . The perfect accompaniment to the P-tox serum.

1 person found this helpful

Profile picture of Gus2000.

Gus2000

from Louisiana

Age Group: 50-59

Wavy, Dry Hair

Mature Skin

Verified Purchase

June 26, 2026

Now this is a WINNER!

Previously I had tried SkinCeuticals P-TIOX serum when it first came out and I felt it was lacking…or maybe I just liked other products better… Anyway, this one is perfect! It does improve the skin laxity and goes great under makeup. I use both morning and evening. Definitely one to consider as it is a premium product that as a woman with mature skin, I am grateful for.

3 people found this helpful

Profile picture of Cate.

Cate

from New York

Age Group: 60-69

Wavy Hair

Mature Skin

June 21, 2026

Better (for me) than the serum

I have sensitive skin and the serum seems to lead to breakouts (even at my “tender” age of almost 70). The cream, when used alone, does not do this. I do have an almost full bottle of serum that I will continue to use on my neck. The cream is wonderful and I do see a difference in as little as 4 weeks. I have tried to use this as directed: serum with the addition of cream It seems to be OK if I only use the serum twice a week.

1 person found this helpful

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