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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$150.00
Highlights
  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream targets deep-set wrinkles with injection-inspired technology.

This advanced peptide cream harnesses patented technology to address the static, deep-set lines that neurotoxin injections alone can't fully correct. 10% MYRIXIN and an anti-wrinkle peptide support a smoother feel while niacinamide, LHA and zinc PCA reveal greater radiance. Tested by physicians, this cream can either enhance your neurotoxin results or stand on its own as a pillar of your anti-aging regimen.

Clinical Results:

  • Hydration is boosted by 94% in just one hour and provides 24-hour hydration
  • Sebum accumulation is reduced by 50% after 8 hours vs untreated skin
  • Wrinkles are visibly reduced by up to 33% after 12 weeks
  • Pore size is reduced by up to 30% after 12 weeks
  • Seven skin quality parameters are visibly improved including skin tone evenness (up to 30%) after 12 weeks

Key Features:

  • Ideal for men and women seeking refined texture and clarity
  • Enhances the results of in-office neurotoxin injections to visibly reduce wrinkles
  • Brings out a glass-skin appearance in just 1 week when used with P-TIOX Serum

Highlights

  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

Ingredients

Directions

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Product Specifications

About the Brand

Customer Reviews (66)

Overall Rating

4.6
Based on 66 reviews

Review Summary

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66 Reviews

Profile picture of Peachie.

Peachie

from Georgia

Age Group: 70-79

Curly Hair

Dry Skin

Verified Purchase

September 12, 2026

Best yet

I have seen a noticeable improvement in texture and cone of my skin using both P-tiox serum and the new cream. It goes in like a dream and doesn't feel greasy. I am even using it around my eyes with to allergic reaction and no puffiness. I love this stuff.

0 people found this helpful

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LovelySkin Customer

from Florida

Age Group: 70-79

Straight Hair

Mature Skin

Verified Purchase

September 12, 2026

P-TIOX

Love, Love this cream! It is light and absorbs very well - suitable for daytime use. I also use this cream at night over serum. Happy with the appearance of my skin. P-TIOX also works well in a humid climate

0 people found this helpful

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author

from Indiana

Age Group: 70-79

Mature Skin

Verified Purchase

September 11, 2026

A POWER HOUSE!

This product is amazing! I love that it can be used ALL over the face. I'm delighted to say I notice an improvement in skin around my eyes.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

September 05, 2026

Wow!!

I love the PTIOX serum, so when I saw they had a cream, I jumped on it and I'm so glad that I did! Amazing!! My skin feels great and looks great! I can see the difference in fine lines and overall appearance. Love!

0 people found this helpful

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sandytp1

from Iowa

Verified Purchase

September 02, 2026

Not moisturizing enough

I didn't think this was moisturizing enough for my dry skin. I really wanted to love it as it was rated the top firming moisturizer by InStyle.

0 people found this helpful

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LovelySkin Customer

from Oregon

Age Group: 60-69

Straight, Color treated hair

Dry Skin

Verified Purchase

September 02, 2026

Great product

I love the way this cream feels. It is so silky. It's makes my skin feel instantly soft and has really brightened my skin. Fine wrinkles are less noticeable too.

0 people found this helpful

Profile picture of AbbyB19.

AbbyB19

from Michigan

Verified Purchase

August 31, 2026

Immediate keeper

I initially found out about this product from lovely skin via the free sample sent . I respect the quality of skinceuticals products but wasn’t aware of this one. It was a nice surprise. My skin’s appearance was immediately smoother and more luminous. It’s a perfect base for the tinted sunscreen I use. I immediately ordered a full size product and will continue to do so.

0 people found this helpful

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AMIGAL

from Florida

Age Group: 50-59

Combination Skin

Verified Purchase

August 27, 2026

Peptides are all the rage...

...so I was pleased to get a sample in my last order. Loved it and purchased a full size. This cream is dreamy going on: light and sinks right in. Very pleased with the results it is having on my skin. I'll be re-ordering this for sure.

0 people found this helpful

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StephieB

from Florida

Age Group: 70-79

Wavy, Color treated hair

Combination Skin

Verified Purchase

August 26, 2026

Skinceuticals P-TIOX Wrinkle Modulating Peptide Cream

I have been using the P-Tiox Serum for quite a while so when the peptide cream came out , I had to try it!! I am very pleased I did, I really love the way it layers on top of the serum, it soaks right in and makes my skin feel soft and supple. I use it morning and evening and I have noticed that my skin doesn’t get that dehydrated look by the end of the day! Definitely a winner!

0 people found this helpful

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Artsmart

from Georgia

Age Group: 70-79

Combination Skin

Verified Purchase

August 21, 2026

Like it.

Really like the way it feels. Seems to be working. Half way through my bottle.

0 people found this helpful

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GabrielaP

from California

Verified Purchase

August 20, 2026

Fantastic cream!

This cream is phenomenal! I use it in the evening and I use the serum version in the morning. It immediately leaves my skin feeling moisturised and glowing. I will continue to use.

1 person found this helpful

Profile picture of Ken.

Ken

Verified Purchase

August 17, 2026

W.O.W.

I cannot believe how well this product works keeping "the elevens" and smile lines at bay. Just one application smooths out the area, and consistent application does seem effective at promoting a more youthful appearance. To be clear, I don't think this product is a miracle that renders cosmetic neuromodulators unnecessary, but I've found it to be an extraordinary performer.

1 person found this helpful

Profile picture of CLC.

CLC

from California

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

August 15, 2026

Luxurious Moisturizer

I use many SkinCueticals products and love them all, but this P-TIOX moisturizer is my new favorite. When applied, it is instantly nourishing for my skin. I live in a dry climate, so am always seeking good moisture; I have found it with P-TIOX.

1 person found this helpful

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LovelySkin Customer

from California

Age Group: 80+

Curly Hair

Normal Skin

Verified Purchase

August 14, 2026

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

The sample of the cream felt really good on my skin and noticed my skin looked better. I immediately ordered the cream. I am in my 80's and this cream made my skin look even better. I have not had any chemical or laser peel to my skin and rely on good products to make my skin look and feel good. I am very happy with this cream.

1 person found this helpful

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Spasmith

from Colorado

Verified Purchase

August 13, 2026

Moisturizing and cooling

I love the consistency of the product and it keeps my skin hydrated through the night.

1 person found this helpful

Profile picture of Bevdog.

Bevdog

from New Mexico

Age Group: 60-69

Verified Purchase

August 13, 2026

ideal for mature skin

I really like the lightweight feel of PTOX cream. I have not necessarily seen results but I'm encouraged by the feel of my skin.

0 people found this helpful

Profile picture of pzg.

pzg

from Idaho

Age Group: 70-79

Mature Skin

Verified Purchase

August 13, 2026

Amazing!

What a nice surprise. Thank you LovelySkin for the sample! My skin is always changing during the seasons. I'm 75! I took a chance on this and boy am I glad I did. The hydration is perfect! My pores seem to calm down. My Rosacea is calmer. Lines seem to soften! Perfect! This is a keeper!

0 people found this helpful

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LovelySkin Customer

Verified Purchase

August 13, 2026

3Goldengirls

NICE PRODUCT- SINKS INTO SKIN-NOT GREASY-NICE UNDER SKIN CEUTICALS TINTED SPF.WOULD PROBABLY USE THICKER CREAM AT NIGHT, BUT DEFINITELY LIKE THIS PRODUCT.

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 60-69

Straight Hair

Mature Skin

Verified Purchase

August 08, 2026

Great Day Time Moisturizer

I love this cream. It is light enough to use under my moisturizing sunscreen, but it is effective enough to moisturize and keep my skin wrinkle-free, and I have actually seen a decrease in oil buildup around my nose and chin area. I use the serum as well, and the two together will keep my 63-year-old skin looking like I am in my 40's :). Thank you, SkinCeuticals, for NOT putting fragrance in this product.

0 people found this helpful

Profile picture of VA.

VA

from Illinois

Age Group: 70-79

Mature Skin

Verified Purchase

August 07, 2026

P-TIOX

Since turning 70, I am dealing with a loss of volume around the corners of my mouth (not nasal labial folds, more around my lower palate). In addition to this disappointing development, my chin seems to be taking on an "orange peel" appearance. YIKES! I just started using this for pore correction on the chin and help with the lines at the corners of my mouth. I feel like sticking cotton balls in this area (like Marlon Brando in The Godfather). I love how the product feels; the texture of the cream is truly wonderful. I don't know yet whether it will help much with the truly scary areas of my face but the parts of face that haven't gone to pot do look better since I started using this cream. Still, I'm hoping for help with the chin and mouth corners and do not want to end up with a Joker mouth so I will not consider injectables, fillers, etc. I figure my jaw is receding and I probably am experiencing some bone loss is this area. Oh well.

2 people found this helpful

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