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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$150.00

Special Offer: Free $20 SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum Deluxe Trial Size!

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Highlights
  • Addresses deep static wrinkles
  • Smooths the look of skin texture

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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream targets deep-set wrinkles with injection-inspired technology.

This advanced peptide cream harnesses patented technology to address the static, deep-set lines that neurotoxin injections alone can't fully correct. 10% MYRIXIN and an anti-wrinkle peptide support a smoother feel while niacinamide, LHA and zinc PCA reveal greater radiance. Tested by physicians, this cream can either enhance your neurotoxin results or stand on its own as a pillar of your anti-aging regimen.

Clinical Results:

  • Hydration is boosted by 94% in just one hour and provides 24-hour hydration
  • Sebum accumulation is reduced by 50% after 8 hours vs untreated skin
  • Wrinkles are visibly reduced by up to 33% after 12 weeks
  • Pore size is reduced by up to 30% after 12 weeks
  • Seven skin quality parameters are visibly improved including skin tone evenness (up to 30%) after 12 weeks

Key Features:

  • Ideal for men and women seeking refined texture and clarity
  • Enhances the results of in-office neurotoxin injections to visibly reduce wrinkles
  • Brings out a glass-skin appearance in just 1 week when used with P-TIOX Serum

Highlights

  • Addresses deep static wrinkles
  • Smooths the look of skin texture
  • Cools skin on contact

Ingredients

Directions

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Availability: In stock & ready to ship! . Ships within the U.S. only.

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Product Specifications

About the Brand

Customer Reviews (85)

Overall Rating

4.6
Based on 85 reviews

Review Summary

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85 Reviews

Profile picture of YDH.

YDH

from California

Age Group: 50-59

Wavy Hair

Combination Skin

Verified Purchase

October 30, 2026

Good But Not Great

I am on the fence on this cream, hence 3 stars. After using it for a few weeks now, I am not sure how good it is at reducing visible lines and correcting pore size, but it does give your skin a glass like appearance. It doesn't break my skin out, which is a plus, but I have to use a moisturizer over this, otherwise my skin feels dry. I would say overall, the results are average. Since the product is pricey, I probably will not repurchase it.

0 people found this helpful

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LoyalCustomer

from California

Age Group: 70-79

Mature Skin

Verified Purchase

October 29, 2026

Happy!

I am so happy with this product! After about 4 weeks, I can actually see some results. It glides on smoothly and absorbs quickly. My skin actually looks less “orange peelish”. Even if there’s not alot of dramatic improvement going forward, the result up to now are noticeably pleasing. Ready to order another one and will most likely put it on auto refill. Thank you Lovely Skin and SkinCeuticals :)

0 people found this helpful

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AmandaSpears

from Maryland

Age Group: 50-59

Wavy, Dry Hair

Dry Skin

Verified Purchase

October 22, 2026

Texture is too light, zero result

Texture is too light it is almost watery like a lotion and I see zero difference or not added comfort. I don't see a difference in skin brightness or evenness or plumpness either, I don't see less wrinkles either... I regret purchasing

0 people found this helpful

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LovelySkin Customer

from Texas

Age Group: 30-39

Combination Skin

Verified Purchase

October 20, 2026

Incredible 11/10

This cream has been the best thing to ever happen to my skin. I've tried it all. I have combination skin and it's the perfect weight. I use it morning and night. My wrinkles on my neck have noticeably reduced as well - better than any neck cream I've tried. I have also had minimal breakouts. Gives me the glass skin I want without being greasy or oily. Truly magic. This is an honest unpaid review!

0 people found this helpful

Profile picture of selkie.

selkie

from California

Age Group: 70-79

Wavy, Dry Hair

Mature Skin

Verified Purchase

October 17, 2026

I really like it

I decided to try this product based on the reviews. I have been using SkinCeuticals Triple Lipid Restore 2:4:2 Anti-Aging Cream for years from when my dermatologist recommended it. Both are moisturizing. The SkinCeuticals Triple Lipid Restore 2:4:2 Anti-Aging Cream does not need any other product while the P-TIOX Wrinkle Modulating Peptide Cream only feels moisturizing for a short time. I put Vanicream on top of it. I don't see any difference yet but do trust the brand.

0 people found this helpful

Profile picture of Enid.

Enid

from Puerto Rico

Age Group: 50-59

Wavy, Color treated hair

Combination Skin

Verified Purchase

October 17, 2026

Silk sensation

I have been using Skinceuticals for many years now. Every time they launch a new product I try it. When you combine this cream with the serum during night you will wake up feeling your skin firm, radiant and smooth.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

October 08, 2026

Outstanding Cream

I took a chance and purchased this cream because I've been using the P-Tiox serum for the past year and love it. The cream does not disappoint. I've used it on my chest, neck and face. The cream is a gel-like consistency and feels cool on the skin, while leaving it lightly hydrated. Also, I'm pleased to report that I have sensitive skin and have had no reaction.

0 people found this helpful

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LovelySkin Customer

from Arizona

Verified Purchase

September 26, 2026

Beautiful results

I am so surprised at how nice this cream is, especially when used with the serum. It goes on smoothly and leaves my skin glowing. Makeup just glides on and the glow shines through!

0 people found this helpful

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4bikes

from North Carolina

Age Group: 40-49

Straight Hair

Normal Skin

Verified Purchase

September 25, 2026

Very hydrating!

This product does a great job hydrating the skin, and it does soften fine lines. I bought it to help Botox last longer. I think it is doing that and this is my second jar.

1 person found this helpful

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LovelySkin Customer

Verified Purchase

September 25, 2026

It’s ok, nothing too noticeable

It doesn’t bother or irritate my sensitive skin. However I did not notice some noticeable “ wrinkle modulation “ . Just a good enough moisturizer which might not be enough for dry skin, especially in cold climates.

1 person found this helpful

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LovelySkin Customer

from California

Verified Purchase

September 24, 2026

Skin care

I love this peptide cream. I pair it with the serum, and it great. Also very nice as a moisturizer. My esthetician had recommended this, and pairing this with the serum leaves my skin looking so healthy and it simply glows. I would absolutely recommend.

0 people found this helpful

Profile picture of Lgugliel.

Lgugliel

from Tennessee

Age Group: 40-49

Wavy, Color treated hair

Combination Skin

Verified Purchase

September 22, 2026

Amazing moisturizer!

Holy grail product! I can’t believe how much this products hydrates and refines skin texture! My skin has never look better.

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 50-59

Combination Skin

Verified Purchase

September 22, 2026

Will buy again

Been using for a month, my face looks slightly brighter, hydrated ( not much difference on wrinkles ) i will purchase again to see if lines around my eyes improve. Not greasy.

0 people found this helpful

Profile picture of Renzy.

Renzy

from Pennsylvania

Age Group: 50-59

Mature Skin

Verified Purchase

September 19, 2026

Great cream

Love this peptide cream. Minimizes fine lines and wrinkles and smooths skin

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 70-79

Mature Skin

Verified Purchase

September 19, 2026

Moisturizing

It seems to be very hydrating. Leaves my skin with a dewy appearance. Haven’t used it long enough to comment on long term benefits.

0 people found this helpful

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LovelySkin Customer

Verified Purchase

September 18, 2026

SkinCeuticals P-TIOX Peptide Cream

I had been using the serum and received a cream sample in the mail. I have found that the cream really made a difference in my skin appearance. If I could afford both I would use both but at this price I can only afford one and the cream works better for me. I would definitely recommend.

0 people found this helpful

Profile picture of LAnnO.

LAnnO

from Texas

Age Group: 50-59

Dry Skin

Verified Purchase

September 17, 2026

P-Tox

Thought I would like this more.

0 people found this helpful

Profile picture of JuW.

JuW

Verified Purchase

September 16, 2026

Love this new face cream

The texture is very pleasant to apply. It is light and silky. It really makes the pores smaller and the skin looks more even. I love this new face cream.

0 people found this helpful

Profile picture of MargaretMarie.

MargaretMarie

from Michigan

Age Group: 30-39

Normal Skin

Verified Purchase

September 16, 2026

My everyday lotion

It is the perfect weight! If you like the ptox serum, you’ll love the lotion. Great for makeup prep as well

0 people found this helpful

Profile picture of Peachie.

Peachie

from Georgia

Age Group: 70-79

Curly Hair

Dry Skin

Verified Purchase

September 12, 2026

Best yet

I have seen a noticeable improvement in texture and cone of my skin using both P-tiox serum and the new cream. It goes in like a dream and doesn't feel greasy. I am even using it around my eyes with to allergic reaction and no puffiness. I love this stuff.

1 person found this helpful

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