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SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum

1.0 fl oz
| HSA|FSA Eligible LMN Required
$150.00
Highlights
  • Smooths 9 types of expression lines
  • Complements neurotoxin injections
  • Reveals glass skin radiance
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Product Overview

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Serum helps reduce nine types of contraction lines and promotes glass skin radiance.

Inspired by the effects of neurotoxin injections, this serum is formulated with an Advanced Peptide Complex and a Glass Skin Complex to smooth nine types of contraction and expression lines to rejuvenate skin for a renewed glow. Neurotoxin injections are a popular in-office treatment used to treat expression wrinkles caused by muscle contractions. 

When paired together, P-TIOX and neurotoxin injections work synergistically to help reduce the appearance of wrinkles, delivering fast, long-lasting results. Versatile and innovative, this serum is also effective on its own to smooth skin, refine pores and reveal glass skin radiance in one week of use. 

Clinical Results:

  • Improves skin smoothness, refines the look of pores and reveals glass skin radiance in one week
  • Visibly reduces fine lines in one week
  • Visibly reduces nine types of contraction lines, even those hard to treat with neurotoxin injections after 12 weeks
  • Visibly reduces global fine lines by 20.6% in 12 weeks

Key Features:

  • Advanced Peptide Complex, comprised of 2% hexapeptide and 2% dipeptide, works together in synergy to fight against contraction lines
  • 5% PHA, 5% niacinamide, and 1% laminaria extract maximize hydration while gently exfoliating to visibly improve skin texture and radiance
  • Tested on all skin tones and types
  • Hydrates skin up to 24 hours after application

Highlights

  • Smooths 9 types of expression lines
  • Complements neurotoxin injections
  • Reveals glass skin radiance

Ingredients

Directions

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Product Specifications

About the Brand

Customer Reviews (269)

Overall Rating

4.4
Based on 269 reviews

Review Summary

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269 Reviews

Profile picture of ctjranderson11.

ctjranderson11

from Pennsylvania

Age Group: 50-59

Combination Skin

Verified Purchase

February 02, 2026

Complements my other Skinceutical products

I started using P-TIOX at the recommendation of a spa consultant. I apply P-TIOX after the application of Silymarin and before the application of HA intensifier multi-glycan. I think I notice a difference, so I am continuing to use it (on my second bottle now).

0 people found this helpful

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AndreaT2552

from Florida

Age Group: 40-49

Straight, Color treated hair

Combination Skin

Verified Purchase

February 01, 2026

It’s lovely

I love this product because it sinks into your skin, it doesn’t feel sticky, it’s very lightweight and I love the results that I’m getting. As a 42-year-old woman who gets Botox and has a little bit more of mature skin. I think this is a great addition to add if you’re looking to include more peptides and help the look of texture and fine lines. Very expensive product, but I do believe it’s worth the price.

0 people found this helpful

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LovelySkin Customer

from California

Age Group: 60-69

Normal Skin

Verified Purchase

February 01, 2026

Didn’t notice a difference

I used the entire bottle, once a day, but didn’t see a difference.

0 people found this helpful

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LovelySkin Customer

from Florida

Verified Purchase

January 30, 2026

It's a great product

After receiving the sample I didn't really think anything would do anymore than what I already use on a 78 year old face. Of course, I tried it and was amazed after one week the difference I was seeing. I didn't know why it looked better but it was enough for me to order a bottle. I use Retin A and I am careful on what days and how I'm using it. The cold weather has also dried me out and I found I was too dry if I used it every day right now. Still figuring it out so I can continue using the Retin A and this product. It has definitely helped the milia around my eyes. Glad I took the chance since my skin seems to be improving every day. It's definitely part of my regime.

0 people found this helpful

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Plg

from North Carolina

Age Group: 70-79

Combination Skin

Verified Purchase

January 28, 2026

Good serum

I like the ingredients in this serum.. goes on well.. absorbs and feels good.. Too soon to speak to the skin improvements.. I use the ce Ferrulic acid in am and this at night under my retin a.

0 people found this helpful

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LarisaLa

from Texas

Age Group: 50-59

Straight, Color treated hair

Dry Skin

Verified Purchase

January 27, 2026

Great Retinol Alternative

I use this on the days I don't use retinol. It goes on smoothly and feels good- seems hydrating. It helps with anti-aging. Highly recommend!

1 person found this helpful

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LovelySkin Customer

Verified Purchase

January 07, 2026

Effective Serum

I started with a free sample of this and went on to purchase the full size. I knew from the sample bottle it was going to be promising because I already saw results. The biggest improvement I've seen is the lines above my lips (they are fine and not deep). They have really softened and are barely perceptible. It has a nice consistency, dries quickly and you don't need a lot. I carefully apply to the eye area and the lip area and around the mouth/corners. Then I just apply the rest to my entire face and pat it in. I used to rub my serums in but I am trying to be more gentle with the pat method and hope that it absorbs well that way. I feel like my skin has a bit more of a glow also. I will see how my skin continues to improve. I use many LovelySkin products (over many years) and am religious about sunscreen so I do think it's a combination of everything that gives me very good results (I am 61). But I will definitely keep this product in the regimen.

1 person found this helpful

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LovelySkin Customer

from Illinois

Verified Purchase

January 02, 2026

This is the best!!

Received a sample and loved it!!!! Currently using the product and love it

0 people found this helpful

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DAH

from Florida

Age Group: 70-79

Normal Skin

Verified Purchase

December 27, 2025

Love. This!

Was told it’s a glass-face effect. It is, and worth the $$$$. A little goes a long way.

1 person found this helpful

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LovelySkin Customer

from Illinois

Age Group: 30-39

Verified Purchase

December 27, 2025

Love the product!

Great product, I don’t see my wrinkles progressing. Also the skin feels great.

0 people found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 20-29

Straight Hair

Verified Purchase

December 26, 2025

Sensitive skin reaction

Let me preface this with the fact that I have sensitive skin so this may not be the case for everyone. I really wanted this peptide to work for me but unfortunately I got a nasty reaction on my chin. Used it for two weeks every other day to every three days, originally I thought my skin was purging so i continued to stick it out. After two-three weeks the "purging" got worse and itchy. I have since discontinued the using this product.

3 people found this helpful

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Yelena

from California

Verified Purchase

December 24, 2025

I can tell the difference

I have been able to stretch Botox appointment by two months by using this serum. I haven’t written a review yet because, I usually like to wait at least until I go through one bottle to see the difference. I am in my second bottle and I do see the difference so I’m planning to keep on using it.

3 people found this helpful

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TShoe

from Colorado

Age Group: 50-59

Wavy Hair

Normal Skin

Verified Purchase

December 21, 2025

Goes on Light

This does not clog pores, goes on lightly, no stink smell, do not know if making a difference yet however light weight and absorbs asap. Not greasy.

1 person found this helpful

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LovelySkin Customer

from Illinois

Age Group: 20-29

Wavy Hair

Combination Skin

Verified Purchase

December 20, 2025

Incredible!

With all the “skintok” craze on TikTok, I’m always skeptical of overly recommended products. But this one really works!! My skin is so smooth and glowing.

1 person found this helpful

Profile picture of DotMH.

DotMH

from California

Age Group: 60-69

Verified Purchase

December 20, 2025

P-Tiox by PCA

It works! I got a new Botox tech. Not thrilled with the results. I put this product on, use my Revive DPL or wand and boom, Botox pick me up!

2 people found this helpful

Profile picture of RG.

RG

from Connecticut

Verified Purchase

December 18, 2025

P-TIOX

This product is a good addition to my daily routine. The solution feels good on my face and it does help reduce the development of new wrinkles.

0 people found this helpful

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LovelySkin Customer

from Georgia

Verified Purchase

December 17, 2025

Great Product

I have very sensitive skin. It helps so much with redness and fine lines

2 people found this helpful

Profile picture of SaltLakeCity.

SaltLakeCity

Age Group: 70-79

Straight, Color treated hair

Oily Skin

Verified Purchase

December 16, 2025

Love Skinceuticals

I rely on SkinCeuticals products and this has helped the tone and quality of my skin. Even as an older user, my skin is smooth and I receive compliments.

3 people found this helpful

Profile picture of Pattiandmom.

Pattiandmom

from Nevada

Age Group: 50-59

Dry Skin

Verified Purchase

December 12, 2025

Excellent addition

If you use Skinscuticals Vitamin C, And you should, Original and still one of Best vitamin C products On market, Add P-tiox to your regimen . It's worth it , an excellent product if you want beautiful skin. Just do it !you'll see the results are wonderful.

4 people found this helpful

Profile picture of Lindaofazchi.

Lindaofazchi

from Arizona

Age Group: 70-79

, Color treated hair

Mature Skin

Verified Purchase

December 08, 2025

Love it

Saw instant results. Got a free sample. Bought full size. Pricy and no sale. I splurged

3 people found this helpful

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