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SkinCeuticals Triple Lipid Restore 2:4:2 Anti-Aging Cream

1.6 fl oz
| HSA/FSA Eligible LMN Required
$155.00

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Highlights
  • Smooths the appearance of fine lines
  • Replenishes nourishing lipids

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Product Overview

SkinCeuticals Triple Lipid Restore 2:4:2 refills cellular lipids and nourishes skin. 

SkinCeuticals Triple Lipid Restore 2:4:2 is an anti-aging corrective treatment formulated with essential lipids at a patented percentage of 2% pure ceramides, 4% natural cholesterol and 2% fatty acids. This unique ratio helps restore the skin's moisture barrier, support natural repair processes and correct signs of aging. The result is an improvement in elasticity, moisture levels and radiance, leaving your skin supple, healthy and radiant.

In an eight-week study, SkinCeuticals Triple Lipid Restore users experienced significant improvement in key visible signs of accelerated aging:

  • 66% improvement in smoothness
  • 35% improvement in laxity
  • 20% improvement in evenness
  • 26% improvement in radiance
  • 44% improvement in pore appearance

In a lipidomic study, use of SkinCeuticals Triple Lipid Restore cream resulted in a:

  • 57% increase in ceramides
  • 50% increase in cholesterol
  • 12% increase in fatty acids in the form of triglycerides

Key Ingredients:

  • Essential Lipids: Featuring natural cholesterol, pure ceramides and fatty acids, they restore skin's youthful elasticity and hydration cycles
  • Vitamin E: Supports natural cell repair and reproduction, helping defend against environmental damage
  • Essential Oils: Packed with antioxidants to fight free-radical damage that is responsible for signs of aging

Key Features:

  • Improves the look of texture, skin tone evenness, and overall radiance
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness
  • Ideal for aging, normal, and dry skin types

Address roughness, dullness and restore facial fullness with SkinCeuticals Triple Lipid Restore 2:4:2.

Highlights

  • Smooths the appearance of fine lines
  • Replenishes nourishing lipids
  • Provides 24 hour hydration

Ingredients

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Return Policy: This product is non-returnable

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Special Shipping Requirements: ORM-D Class
ORM-D classified products such as aerosol sprays, nail polish, perfume and products with high alcohol content may only be shipped using a ground method within the Continental US.

Availability: In stock & ready to ship! . Ships within the U.S. only.

Questions & Answers (12)

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Product Specifications

About the Brand

Customer Reviews (2327)

Overall Rating

4.8
Based on 2327 reviews

Review Summary

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2327 Reviews

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LovelySkin Customer

Verified Purchase

October 08, 2026

best anti aging+moisturizer

The triple lipid from skinceuticals is really a golden lotion for face and neck that combines the anti-aging with the moisturizer and can be used anytime of the day. It also makes your skin super soft. Highly recommended.

0 people found this helpful

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LovelySkin Customer

from Alabama

Age Group: 70-79

Dry Skin

Verified Purchase

October 03, 2026

Love this moisturizer!

This is the best moisturizer that I have ever used. Not too heavy, either. I have dry skin, and using it nightly makes such an improvement of my skin texture.

1 person found this helpful

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kurleeq1034

from West Virginia

Age Group: 40-49

Normal Skin

Verified Purchase

October 01, 2026

Helped my skin heal from perioral dermatitis

I was apprehensive about adding a new product to my limited routine in an effort to manage the perioral dermatitis I fought for over a year. This product seemed to help my facial skin barrier and melasma.

3 people found this helpful

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Renzy

from Pennsylvania

Age Group: 50-59

Mature Skin

Verified Purchase

September 30, 2026

Keeper!

Love this moisturizer for mature skin. Goes on smooth and doesnt feel greasy. Perfect for overnight.

2 people found this helpful

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LovelySkin Customer

from Georgia

Age Group: 60-69

Mature Skin

Verified Purchase

September 25, 2026

Excellent

I was going through a drawer full of samples that I had collected over the past year and after trying a sample of this product, I ordered a jar the next time it was on sale. The cream does not pill and creates a nice moisture barrier for the day.

3 people found this helpful

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Anniern

from Louisiana

Age Group: 60-69

Straight, Color treated hair

Dry Skin

Verified Purchase

September 25, 2026

Best product I have ever used

I have been using Triple Lipid Restore 2-4-2 for over 10 years. It is great for mature dry skin. I am over 65.

2 people found this helpful

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Brindi

from North Carolina

Age Group: 50-59

Normal Skin

Verified Purchase

September 22, 2026

Excellent product

I have used this cream for 15 years. It is a staple in my skincare regimen. A quality foundational product.

4 people found this helpful

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Ldl

from Florida

Verified Purchase

September 21, 2026

My Favorite

This is my favorite moisturizer. Well worth the price.

4 people found this helpful

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LovelySkin Customer

from Texas

Age Group: 80+

Dry Skin

Verified Purchase

September 21, 2026

Purchased for Mom

My Mom was low on face cream and I shared with her some samples that I had received in the mail that were not right for my skin but perfect for hers. She tried the samples and said it made her skin feel moisturized and soft. Mom is in her 80's and has dry skin. She didn't have anything negative to say after finishing the jar. She was using a very expensive face cream that just was no longer in the budget to keep purchasing and this face cream was an excellent replacement. It's always great when there are sales which makes it even better.

5 people found this helpful

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LovelySkin Customer

from Iowa

Verified Purchase

September 19, 2026

Great for dry skin

Great for crepey skin. Can tell if I don’t use it for a few days

4 people found this helpful

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LovelySkin Customer

from California

Verified Purchase

September 18, 2026

Not cheap

This cream restores my skin barrier, making it a good companion for my Retinol routine! It nourishes, though the painfully steep price tag is a definite drawback.

3 people found this helpful

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LovelySkin Customer

from Michigan

Verified Purchase

September 17, 2026

Love it

Introduced to this by my medical aesthetician and found that it is beneficial for my mature skin. Love the way it makes me feel. I wear it under SkinCeuticals sunscreen. Doesn’t feel heavy. I’ve learned less is more with this product!

3 people found this helpful

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LAnnO

from Texas

Age Group: 50-59

Dry Skin

Verified Purchase

September 17, 2026

Best Moisturizer for Mature Skin

Triple Lipid is on reorder!

2 people found this helpful

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Kmaska

from Idaho

Age Group: 50-59

Curly hair, Damage & split ends

Combination Skin

Verified Purchase

September 13, 2026

Must have!

I don’t know why but I held off trying this moisturizer for years, I think mainly because my skin has not liked every other skinceuticals product. I finally started using this a couple months ago. Literally a game changer for my skin. I am micro dosing Isotrentinoin, use arazlo every other night, am in menopause, and live in the high desert. This moisturizer is thick and luxurious, I use at night & wake up with soft replenished skin. I also use tiny bit mixed with my day moisturizer just for an extra oomph. I love, love, love this product & highly recommend! Will never stop using, I just want to add I have sensitive reactive skin but have not had any issues with the essential oils in this product, nor does it clog pores

2 people found this helpful

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LovelySkin Customer

Age Group: 50-59

Combination Skin

Verified Purchase

September 11, 2026

Amazing Corrective Cream

Over the past couple of years I've received many samples of Triple Lipid Restore 2:4:2 and finally tried it out. I'd been using several different products on my neck and was never satisfied; however, after about six weeks of using Triple Lipid Restore, the skin on my neck was visibly smoother/softer, and the fine vertical lines at the bottom are less apparent. Amazing product.

3 people found this helpful

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1381new

from Alabama

Verified Purchase

September 02, 2026

My skin loves it

Very nice product. So moisturizing I have cut back on daytime use due to the heatwave in my state. Apply in the evening and skin feels great in the morning.

7 people found this helpful

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AndreaV

from New York

Verified Purchase

August 27, 2026

My go to

Wonderful moisturizer for my 60-something skin.

8 people found this helpful

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Mimi29

from Virginia

Age Group: 70-79

Straight, Color treated hair

Mature Skin

Verified Purchase

August 24, 2026

Hydrating

Great moisturizing for aging skin

9 people found this helpful

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LovelySkin Customer

from North Carolina

Age Group: 50-59

Mature Skin

Verified Purchase

August 19, 2026

Perfect

I am a new user of Treninoin cream and needed a super thick moisturizer that helped as my skin sheds. This is doing the trick. My peeling has calmed down, subtle scent and feels like a babies skin. Love this!

8 people found this helpful

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DCarter

from Alabama

Age Group: 80+

Wavy Hair

Verified Purchase

August 18, 2026

The best moisturizer

Amazing barrier support, especially at night after using retinol. Amazing barrier repair and soothing effect

7 people found this helpful

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