SkinMedica TNS Advanced+ Serum - 3 Pack

Product Overview

SkinMedica TNS Advanced+ Serum - 3 Pack offers the classic formula, now supercharged.

This SkinMedica serum builds upon the legendary results of its predecessor for powerful anti-aging. Every piece of the TNS Essential serum, from the peptides to the growth factors has been rethought and amplified. Because of this, it's even better at softening wrinkles, diminishing dark spots and addressing other signs of aging.

Formulated with TNS-MR, the next-generation growth factor blend, this serum acts on multiple levels of the skin to achieve the best results. Additionally, Renessensce (RSC) Advanced, a highly active blend of botanicals, peptides and marine extracts, supports skin renewal for plumper, more youthful skin, delivering results in as little as two weeks.

Set Includes:

SkinMedica TNS Advanced+ Serum (3 x 1.0 fl oz)

Key Features:

New Innovative 2 Tripeptide Complex visibly firms and smooths fine lines and wrinkles
Potent blend of Spanish Marine extract and Green Microalgae builds collagen and supports skin's repair process
Provides antioxidants for improved defense against environmental stress
Visibily lifts sagging skin while improving skin tone and texture
In studies, users felt they looked up to 6 years younger after 12 weeks
Fragrance-free and paraben-free

Experience a breakthrough in anti-aging science with SkinMedica TNS Advanced+ Serum.

Highlights

Fragrance-free
Boosts collagen and elastin production
Contains growth factors

Ingredients

Directions

Shipping & Returns

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Product Specifications

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About the Brand

Customer Reviews (2023)

Overall Rating

4.6

Based on 2023 reviews

Review Summary

5 Stars

1614

4 Stars

247

3 Stars

2 Stars

1 Star

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2023 Reviews

KJTS

from Texas

Age Group: 50-59

Wavy, Color treated hair

Dry Skin

Verified Purchase

August 04, 2026

Amazing!

I have used this serum for years and it leaves my skin glowing! I love the new packaging!

0 people found this helpful

LovelySkin Customer

from Ohio

Age Group: 50-59

Wavy Hair

Combination Skin

Verified Purchase

August 03, 2026

TNS Advance + Serum

I used TNS Advance + Serum for years & years directly through the Skinmedica site. I stopped because I couldn’t justify the extra $295.00 every 2 months any longer. I started noticing the difference in my skin within six months of discontinuing the product. I just looked much older and not as fresh. The product really works, thank God I found lovely skin. It’s more affordable and I’m getting my skin back to what I remember and also because it’s more affordable, I can try other skinmedica products.

0 people found this helpful

TaraIsGreat

from New Jersey

Age Group: 50-59

Straight Hair

Mature Skin

Verified Purchase

July 31, 2026

Excellent

An esthetician introduced this to me a few years ago and I had forgotten just how good it is. Almost immediately you will see an improvement in your skin's texture. I put it on immediately after cleansing and let it seep in for a few minutes before following with moisturizer. This is a superior serum. It is definitely worth the price. Put it on auto ship for the discount. Your skin will thank you.

0 people found this helpful

shebail

from Virginia

Age Group: 60-69

Straight Hair

Combination Skin

Verified Purchase

July 31, 2026

TNS Advance Serum

I have used this product for a few years as part of my skin care routine and see visible results.

0 people found this helpful

LovelySkin Customer

Verified Purchase

July 30, 2026

still waiting for results, but seems to be working

easy to mix, with results starting after two months, am excited to see if it really regenerates.

0 people found this helpful

LovelySkin Customer

from New York

Verified Purchase

July 27, 2026

Love!

I have only been using for one month - but, can already notice the difference! Worth the price!

0 people found this helpful

LovelySkin Customer

Age Group: 40-49

Dry Skin

Verified Purchase

July 24, 2026

faulty pump & other issues

Broke me out and I can't stand the pump. Both sides would not evenly come out. I didn't pay the hefty price to deal with this and returned it.

1 person found this helpful

LovelySkin Customer

from Florida

Age Group: 30-39

Verified Purchase

July 24, 2026

Not sure if worth the $$$

I bought this serum two times so far and one bottle has lasted me about 1.5 months if used 1x a day. It is very expensive and I am not sure if it is worth the price. Haven’t noticed any major difference in skin texture or fine lines. I believe there are other products that don’t cost as much that can produce the same or better. I will try something else out.

3 people found this helpful

LovelySkin Customer

Verified Purchase

July 20, 2026

Pricey but worth it

This product deserves the awards it receives. It really does what it claims, and I think that anyone interested in adding growth factors to their routine should strongly consider it. That said, it is very expensive (by my standards, anyway); however, its effectiveness outweighs the cost, in my opinion. It is a staple in my carefully curated skincare routine.

3 people found this helpful

LovelySkin Customer

from Arizona

Age Group: 40-49

Mature Skin

Verified Purchase

July 18, 2026

Wonderful for the neck area

This im my favorite neck-area product, as I feel it is more gentle and moisturizing than the TNS gel, so I mainly apply this to my neck each morning. It has been the one thing that seems to help that area the most for me! I know everyone's skin is different, but this seems to work for me so far, and it is expensive, but I will repurchase!

1 person found this helpful

LovelySkin Customer

from Virginia

Age Group: 60-69

Wavy Hair

Mature Skin

Verified Purchase

July 18, 2026

TNS Serum Works

I’ve been using TNS serum for 3 years and it works. It softens and reduces fine lines. You mix the two serums together and my skin is softer and less age lines. Try it

1 person found this helpful

LovelySkin Customer

from Louisiana

Age Group: 50-59

Curly, Dry Hair

Mature Skin

Verified Purchase

July 15, 2026

I believe this helps

I am 59 years old (this August) and have used TNS and SkinCeuticals CE Ferulic every morning for several years. While I cannot attest to how my skin would look had I not, what I can say is this - I've had zero work done - no plastic surgery, no fillers, no Botox, etc. I'm aging naturally (the horror!), and people often tell me I look great for my age. I'm not saying I don't have wrinkles, or that this prevents them entirely, but when I look back at photos from five years ago, before I started using this combination with moisturizer and sunscreen, I honestly think my fine lines and wrinkles look better now. It's an expensive indulgence, especially both, I think (hope) worth it.

2 people found this helpful

LovelySkin Customer

from Oregon

Verified Purchase

July 15, 2026

Great product

Really makes a difference skin looks more healthy after just several weeks

1 person found this helpful

NatashaMayB

from California

Age Group: 50-59

Wavy, Color treated hair

Mature Skin

Verified Purchase

July 14, 2026

Best !!!

The best of the best, hands-down, it may be a splurge, but if this one product to have and use faithfully, it's this one been using it for 20 years and so happy I have.

0 people found this helpful

LovelySkin Customer

from Michigan

Age Group: 50-59

Normal Skin

Verified Purchase

July 12, 2026

Worth it

Have been using for 6 months and have noticed a difference regarding fine lines around eye area and upper lip. I will continue to purchase

0 people found this helpful

SunnyKay

from Oklahoma

Age Group: 40-49

Wavy Hair

Combination Skin

Verified Purchase

July 10, 2026

Absolute Must Have

I’ve tried a lot of skincare over the years, but TNS is the one product I never want to be without. My skin looks smoother, healthier, and just has that rested glow even on days I’m running on very little sleep. It’s definitely an investment, but for me it’s 100% worth every penny.

1 person found this helpful

LovelySkin Customer

from Maryland

Age Group: 50-59

Combination Skin

Verified Purchase

July 10, 2026

Pilling on my skin

I purchased the TNS Advanced +serum after extensively researching medical grade products. I purchased an entire SkinMedica line including TNS, Even and Correct cream, dark spot corrector, TNS under eye cream, and 1% retinol. I was looking forward to amazing results. I am happy with all of the other products and I’m seeing a difference in my skin. I have followed the directions of applying the TNS first to clean dry skin, and it is continuously pilling. If I try to apply any of my products over top of it, I have pilling as well. I have been careful waiting for the product to absorb into my skin before applying additional products. I wanted to love the TNS, but it just isn’t working for my skin. It is way too expensive to have pilling every time I use it. Now I need to search for a different product. The rest of the SkinMedica products have been great.

3 people found this helpful

LovelySkin Customer

from North Carolina

Age Group: 40-49

Wavy, Color treated hair

Normal Skin

Verified Purchase

July 09, 2026

So far, so good

I haven’t been using this long enough to see results, but it doesn’t irritate my sensitive skin or trigger rosacea, so that is already a plus.

0 people found this helpful

LovelySkin Customer

from Alabama

Age Group: 70-79

Wavy, Dry Hair

Normal Skin

Verified Purchase

July 07, 2026

TNS

This is another product I keep buying because all my research says it’s the best for what it’s supposed to do. If that’s the case, I can’t imagine what I would look like if I didn’t use it every day.

1 person found this helpful

KristiCagg

from California

Age Group: 50-59

Verified Purchase

July 05, 2026

Fabulous product….BUT!!!

I’ve used this for the last year, it performs exactly as promised with delivery of better tone and texture and overall brightness to the skin and minimization of fine lines. It really is excellent. The only drawback is the delivery system. 1) it is a large bottle with not a lot of ounces inside and it has two pumps to be dispersed ideally simultaneously, yet leaves the user wondering did I get equal parts for optimal facial application. 2) due to the bottle size, you can’t travel with it and decanting it’s two syrums is high maintenance. PLEASE SKINMEDICA - create a travel size sample for us loyal gals that love this product and want the convenience of traveling with it!

4 people found this helpful

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SkinMedica TNS® Advanced+ Serum - 3 Pack

Product Overview

SkinMedica TNS Advanced+ Serum - 3 Pack offers the classic formula, now supercharged.

Highlights

Ingredients

Directions

Shipping & Returns

Questions & Answers

Product Specifications

Special Offers

About the Brand

Customer Reviews (2023)

Overall Rating

Review Summary

Write a Review

Amazing!

TNS Advance + Serum

Excellent

TNS Advance Serum

still waiting for results, but seems to be working

Love!

faulty pump & other issues

Not sure if worth the $$$

Pricey but worth it

Wonderful for the neck area

TNS Serum Works

I believe this helps

Great product

Best !!!

Worth it

Absolute Must Have

Pilling on my skin

So far, so good

TNS

Fabulous product….BUT!!!

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