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This SkinMedica serum builds upon the legendary results of its predecessor for powerful anti-aging. Every piece of the TNS Essential serum, from the peptides to the growth factors has been rethought and amplified. Because of this, it's even better at softening wrinkles, diminishing dark spots and addressing other signs of aging.
Formulated with TNS-MR, the next-generation growth factor blend, this serum acts on multiple levels of the skin to achieve the best results. Additionally, Renessensce (RSC) Advanced, a highly active blend of botanicals, peptides and marine extracts, supports skin renewal for plumper, more youthful skin, delivering results in as little as two weeks.
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Experience a breakthrough in anti-aging science with SkinMedica TNS Advanced+ Serum.
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1947 Reviews
platinumprotocol
from Washington
Age Group: 30-39
Normal Skin
Verified Purchase
as someone who already has all the skincare essentials, including daily tretinoin, vitamin c, and spf, i didn't think there was much room for improvement. i was wrong. the tns advanced+ serum is the ultimate 'last bit of oomph' my skin needed. it give my skin a 'snatched,' firm look that my other actives couldn't reach alone. the healing properties are amazing, too. whether it’s post-procedure recovery or just everyday 'renovation,' this is my absolute holy grail. yes, it’s mega proxy but… it’s worth every penny.
2 people found this helpful
Myo
from International
Verified Purchase
SkinMedica TNS Advanced+ Serum is easily one of the most advanced anti-aging serums I’ve tried. The formula feels luxurious, absorbs beautifully into the skin, and works well both morning and night. After a few weeks of consistent use, my skin looked smoother, healthier, and noticeably more radiant. What really stands out is how this serum addresses multiple concerns at once—fine lines, texture, and overall skin firmness. It truly feels like a professional-grade treatment in a bottle, and the dual-chamber technology is a clever way to combine powerful ingredients. My only suggestion would be regarding the price. While the product performs well and the ingredients are clearly high quality, the current price point may make it difficult for many people to maintain long-term use. If the brand ever offered slightly lower pricing, refill options, or loyalty discounts, I believe even more customers would adopt this serum as a permanent part of their skincare routine. Overall, this is a fantastic product that delivers visible improvements—just hoping it becomes a little more accessible so more people can enjoy it regularly.
9 people found this helpful
Nanawest
Age Group: 70-79
Mature Skin
Verified Purchase
This is what I come back to everytime. I do try other products and this is not the only thing I use, but for overall skin texture, smoothness, tone and such this is stellar. Now that they have fixed the poor pump system it is even better!
4 people found this helpful
Jameson
from North Carolina
Age Group: 40-49
Curly hair, Dry/flaky scalp
Mature Skin
Verified Purchase
I have been using this only at night for over 5 years. Everyone I know tells me my skin looks better now than it did when I was in my early 30’s, and I’m in my late 40’s now. This miracle in a bottle is phenomenal in building that collagen that we women start to lose as we age,starting at 30. Also, I hated the old bottle,so I was so happy when they changed it,cause this bottles pump works so much better.
5 people found this helpful
SkincareSelfcare
from Oregon
Age Group: 40-49
Mature Skin
Verified Purchase
The results of this product have been undeniable for me. It gives my 45 year old face a glass skin look with a couple uses. Very nice product. I docked one star because the there is something about the smell and texture that I don't love, borderline yuck. Also, you have to use two dispensers for two separate products and I don't know if I'm using an equal portion until I'm out of one.
2 people found this helpful
TLVRN123
from Kentucky
Age Group: 50-59
Mature Skin
Verified Purchase
Love this product. I am 57 and have tried many GF with no improvement. After 2 weeks I can already tell the difference in my skin. I can see slight improvement in fine wrinkles and feel my elasticity has improved. Will be purchasing again!
3 people found this helpful
LovelySkin Customer
from Massachusetts
Age Group: 50-59
Verified Purchase
I really like the TNS! It goes on smooth and settles in skin nicely. Skin is looking good!
1 person found this helpful
LovelySkin Customer
from California
Verified Purchase
Ever since I started using this serum, my skin has felt tighter and more firm and my wrinkles look much less noticeable. I have been using this serum for year and plan to keep using it in the future. Thank you Skin Medica!
1 person found this helpful
GiaB
from Florida
Age Group: 60-69
Straight Hair
Mature Skin
Verified Purchase
I read about TNS Advanced for the longest time and finally decided to bite the bullet. This is actually my second bottle. It’s hard to explain what it does. I only know that if I stop using it, there’s a difference. It doesn’t reverse what’s already there, but it does enhance your skin. It’s pricey, but it’s worth it. I can compromise on moisturizers and some other products but this has become a staple.
3 people found this helpful
LovelySkin Customer
Age Group: 50-59
Mature Skin
Verified Purchase
I have used this and a growth factor serum from a different brand and I think this one may have a tiny edge over the other brand in what it does for the skin, but not enough to warrant the much higher price. The other brand actually has pretty good sales, but unfortunately SkinMedica is one of those brands that rarely has sales and they are not too significant when they do. If you can afford the cost then I would say go for this one, but if you are trying to save a little and make your dollar go further than I would try the other.
3 people found this helpful
LovelySkin Customer
from Montana
Age Group: 40-49
Verified Purchase
I absolutely love it. I can see difference already. Fine lines around my eyes are much softer, my skin looks “awake”, fresh! I have rosacea and very sensitive skin, I have zero reactivity to this product. Highly recommend! It is expensive but I purchased it when it was on sale so it was a little bit more affordable.
2 people found this helpful
LovelySkin Customer
from Indiana
Age Group: 50-59
Verified Purchase
Love this product!
2 people found this helpful
LovelySkin Customer
from Tennessee
Age Group: 80+
Straight Hair
Normal Skin
Verified Purchase
I have used TNS for years. It helps improve the texture of my skin and smooths out fine wrinkles. I tried other products but came back to TNS because I saw a difference. It’s the best even though it is expensive!
3 people found this helpful
maryt
from Illinois
Age Group: 40-49
Wavy hair, Damage & split ends
Mature Skin
Verified Purchase
Awesome serum, and the new packaging is a huge improvement
2 people found this helpful
Pati
from North Carolina
Age Group: 60-69
Wavy Hair
Mature Skin
Verified Purchase
I love this product and have been using it for years. My dermatologist recommended it.
3 people found this helpful
Burg
from Virginia
Verified Purchase
I am late to the design change of this dispenser. I DO NOT like the dual action pump. Small amounts of both ingredients do not come out equally. And then am I supposed to mix it myself? The product is excellent and I have been a loyal user since it was first introduced but thinking now of finding something simpler. This is not produced for the mature client but for youngsters who enjoy experimenting. At this price point, I expect fluidity.
4 people found this helpful
ARosario
from Florida
Age Group: 50-59
Wavy Hair
Normal Skin
Verified Purchase
I’ve used this product for 15 years and my skin is noticeably different when I skip a day. It is light, effective and the perfect addition to my routine! It does what it says.
3 people found this helpful
Rosalyn
from Ohio
Age Group: 50-59
Verified Purchase
Wish I either didn't like it as much OR it was BOGO Lol
4 people found this helpful
DanaAZ
from Arizona
Age Group: 60-69
Curly Hair
Mature Skin
Verified Purchase
I've been using this product for a decade. It's incredible for my skin and anti-aging. Everyone thinks I'm 15 years younger than i am. But the delivery system was not always terrific. They have now created a fail safe delivery system that ensures both products come out evenly and easily. Thank you so much skinmedica.
4 people found this helpful
LovelySkin Customer
from Puerto Rico
Verified Purchase
My favorite serum !! Mi skin look real radiant !! Is my second bottle .
0 people found this helpful