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Ingredient spotlight: Azelaic acid with Effaclar AZ Gel

by Ashlei|January 28, 2026
Ingredient spotlight: Azelaic acid with Effaclar AZ Gel

When it comes to hardworking skin care ingredients, azelaic acid deserves a place in the spotlight. This gentle yet powerful multitasker tackles everything from stubborn breakouts to lingering dark spots and early signs of aging - all without the irritation that often comes with other active ingredients. If you've been searching for a solution that addresses multiple concerns at once, La Roche-Posay Effaclar A.Z. Gel Azelaic Acid Acne Treatment makes it easy to harness the benefits of this dermatologist-recommended ingredient.

What is azelaic acid?

Azelaic acid is a naturally occurring compound found in grains like wheat, rye and barley. In the world of skin care, it has become a trusted ingredient for those dealing with multiple concerns simultaneously. What sets it apart from other active ingredients? While many ingredients focus on just one skin issue, azelaic acid works on several fronts to improve your overall complexion.

The benefits of azelaic acid for your skin

Azelaic acid offers impressive versatility for a range of skin concerns:

Fights acne at the source: It eliminates acne-causing bacteria while keeping pores clear, which means you're not just treating current breakouts - you're actively preventing future ones.

"Azelaic acid is one of my go-to recommendations for patients dealing with post-inflammatory hyperpigmentation," says board-certified dermatologist, Mohs surgeon and cosmetic surgeon Dr. Joel Schlessinger.

"It's particularly effective because it targets pigmentation at multiple levels, slowing melanin production while also providing gentle exfoliation to help fade existing dark spots. What makes it especially valuable is that it does this without causing the irritation or sensitivity that some other brightening ingredients can trigger."

Fades post-acne marks: Dark spots left behind after breakouts can be just as frustrating as the blemishes themselves. Azelaic acid inhibits tyrosinase, the enzyme responsible for melanin production, helping those stubborn marks fade more quickly.

Calms redness and inflammation: If you struggle with redness or inflamed skin, azelaic acid's anti-inflammatory properties work to soothe irritation and create a more even complexion.

Smooths skin texture: Regular use helps refine rough, bumpy skin and minimize the appearance of pores for a smoother, more polished look.

Gentle on sensitive skin: Unlike some powerful actives that can cause excessive dryness or irritation, azelaic acid is generally well-tolerated, making it an excellent option for those with reactive skin.

Safe in pregnancy and breastfeeding: Unlike the large majority of over-the-counter and prescription topical treatments for acne and pigmentation, such as retinols (which are not safe during pregnancy and breastfeeding), studies of azelaic acid have shown no evidence of fetal harm, and it has low systemic absorption when applied topically.

Board-certified dermatologist, Mohs surgeon and cosmetic surgeon, Dr. Daniel Schlessinger notes, "What I appreciate most about azelaic acid is its multi-purpose uses for both acne, rosacea and excess pigmentation. Many of my patients struggle with sensitive, reactive skin that can't tolerate traditional acne treatments, and azelaic acid offers them an effective alternative. Its anti-inflammatory and antibacterial properties make it uniquely suited for addressing multiple concerns without compromising the skin barrier."

La Roche-Posay Effaclar AZ Gel: A proven azelaic acid treatment

La Roche-Posay designed Effaclar AZ Gel to address the unique needs of skin dealing with both recurring breakouts and early signs of aging. The formula combines azelaic acid with 1.2% salicylic acid to deliver comprehensive action against blemishes, stubborn post-acne marks, loss of elasticity and wrinkles.

This hydrating, ultra-fast absorbing gel-cream penetrates deep into pores to control existing acne while helping prevent new blemishes from forming. It also includes hyaluronic acid, a moisture-binding ingredient that helps keep skin hydrated throughout the treatment process. Following La Roche-Posay's strict formulation standards, the product has been rigorously tested for both efficacy and safety, even on sensitive skin.

How to use Effaclar AZ Gel

Getting started with Effaclar AZ Gel is straightforward, but there are a few important steps to follow for best results:

Begin by shaking the bottle well, then thoroughly cleanse your skin. Apply a thin layer to cover the entire affected area. Because azelaic acid can cause some initial dryness, it's best to start slowly - apply once daily at first, then gradually increase to two or three times daily as your skin builds tolerance.

Incorporate Effaclar AZ Gel into your routine after cleansing and before moisturizing. Always finish your morning routine with a broad-spectrum sunscreen, as azelaic acid can increase sun sensitivity. Be careful to avoid the eye area during application.

Who should use azelaic acid?

Azelaic acid is particularly beneficial if you're experiencing:

  • Recurring acne breakouts that seem to appear in the same spots
  • Dark marks that persist long after blemishes have healed
  • Early signs of aging, like fine lines and loss of firmness
  • Uneven texture or enlarged pores
  • Multiple concerns that require both clarifying and anti-aging benefits

This ingredient is especially appealing if you want to see real improvement in your skin's clarity and texture without dealing with harsh side effects.

Ready to try azelaic acid?

Azelaic acid stands out as a multifunctional ingredient that works hard without working against your skin. La Roche-Posay Effaclar AZ Gel harnesses this powerful ingredient alongside salicylic acid and hyaluronic acid for a well-rounded approach to clearer, healthier-looking skin. Clinical studies demonstrate that with consistent use, wrinkles appear reduced and skin looks firmer. Whether you're managing recurring breakouts, working to fade persistent post-acne marks or addressing the first signs of aging, this dermatologist-backed treatment offers a gentle yet effective path to achieving your skin care goals.

Interested in learning more ways to keep your skin healthy and glowing with La Roche-Posay? Learn all about La Roche-Posay’s newest formula for balanced skin on the LovelySkin blog.