Advanced RGN-6 and Triple Lipid Restore 2:4:2 are two of SkinCeuticals' most buzzworthy anti-aging corrective creams. Both are dermatologist-backed, clinically tested and formulated to improve skin health from different angles. So, what are the key differences between them, which is right for you and should you be using both? Read on to learn the answers to these top questions.

SkinCeuticals SkinCeuticals Advanced RGN-6 Regenerative Cream

The regeneration powerhouse

SkinCeuticals Advanced RGN-6 Regenerative Cream is a revolutionary regenerative cream meticulously crafted to enhance skin repair and rejuvenation. Developed over five years in collaboration with global skin regeneration scientists, its formula is inspired by the cutting-edge science behind laser treatments, aiming to promote a more youthful complexion. This patented, multi-corrective formula is a great option for anyone looking to address multiple signs of aging and damage in the skin for a rejuvenated look.

Key technology

At its core, Advanced RGN-6 boasts six synergistic actives inspired by laser regeneration science. These powerful ingredients work together to trigger six dimensions of repair within the skin, helping to reverse visible signs of aging and skin tone damage.

Product details

• Perfect for: All skin types, including sensitive.
• Skin concerns: Firmness, wrinkles, stubborn discoloration (including post-blemish marks) and redness.
• Texture: A lightweight, comforting emulsion that absorbs beautifully.
• Pairs best with: In-office laser treatments, as it's physician-tested to complement procedures and help reduce downtime.

Visible benefits

• After 1 week: Helps reverse visible aging damage from 1 week with daily use.
• After 12 weeks: Advanced RGN-6 was clinically shown to help reduce visible redness by up to 69% and increase skin firmness by up to 35%.
• Post laser treatment: When applied post treatment Advanced RGN-6 helps reduce downtime, skin is visibly less rough, smoother and more hydrated.

SkinCeuticals Triple Lipid Restore 2:4:2 Anti-Aging Cream

The barrier repair icon

A true icon in barrier repair, SkinCeuticals Triple Lipid Restore 2:4:2 Anti-Aging Cream remains one of SkinCeuticals' best-selling corrective creams for dehydrated and aging skin. The formula features a patented and optimal combination of 2% ceramides 1 +3, 4% cholesterol, 2% fatty acids, all of which are essential lipids that play a crucial role in the health of our skin barrier. These lipids act as a sealant, preventing moisture loss and protecting the skin from external irritants. Triple Lipid Restore 2:4:2 helps address lipid loss in the skin, whether due to the natural aging process or external stressors.

Key technology

The magic lies in its precise 2:4:2 lipid ratio, clinically proven to significantly improve the skin's barrier resilience by up to 30% in just one week. Triple Lipid Restore 2:4:2 replenishes essential lipids in the skin with 2% ceramides 1+3, 4% cholesterol and 2% fatty acids for a smoother, hydrated and radiant complexion.

Product details

• Perfect for: All skin types, including sensitive.
• Skin concerns: Dryness, dehydration, dullness and compromised skin barrier.
• Texture: A rich, luxurious cream that melts into the skin.
• Pairs best with: Retinoids, as it's known to shorten the adjustment period and reduce associated dryness.

Visible benefits

• After 8 weeks: Triple Lipid Restore 2:4:2 was shown to help improve smoothness by up to 66%, pore appearance by up to 44% and radiance by up to 26%.
• Retinoid support: Dramatically shortens retinoid adjustment periods (up to one week) and significantly reduces dryness.

Can you use both?

You can absolutely use both Advanced RGN-6 and Triple Lipid Restore 2:4:2 in your daily anti-aging routine to achieve amplified results. You can either layer them by applying Advanced RGN-6 first, then following with Triple Lipid Restore 2:4:2 or use one in the morning and reach for the other in the evening.