Your GLP-1 weight loss journey has transformed your body, but unexpected facial changes, like hollowed cheeks, deepened lines and loss of fullness, may have you concerned. Fortunately, the right skin care strategy can help with your facial appearance throughout your transformation.

What is Ozempic face?

Ozempic face describes facial volume loss and skin changes from rapid weight loss with GLP-1 medications like Ozempic, Wegovy and Mounjaro. When you lose significant weight quickly, you also lose subcutaneous fat, which provides facial structure and plumpness.

"The facial changes we see with rapid weight loss are the result of both fat loss and the skin's inability to adjust at the same pace," explains board-certified dermatologist, cosmetic surgeon and Mohs surgeon Dr. Joel Schlessinger. Common signs include sunken cheeks, hollow temples, deeper nasolabial folds, more visible jowls and an overall aged appearance.

"Rapid weight loss causes skin laxity because it results in loss of volume, which is why GLP-1 users who have lost weight quickly find it can be especially noticeable," says Dr. Daniel Schlessinger, who is also a board-certified dermatologist, cosmetic surgeon and Mohs surgeon.

How to avoid Ozempic face: A proactive approach

While some facial volume loss may be inevitable with significant weight loss, scientifically backed strategies can minimize its appearance. The key is to start early and use clinically proven products.

"GLP-1 patients need a multipronged approach in order to counteract the effects of their weight loss," says Dr. Joel Schlessinger. "One of my favorite over-the-counter skin care lines for these patients is SkinCeuticals as it offers innovative formulations that target skin biology at a cellular level."

SkinCeuticals’ advanced ingredients are designed to support the skin during significant physiological changes, making them ideal companions for individuals on a GLP-1 medication regimen.

SkinCeuticals A.G.E. collection: Targeted solutions for volume loss

The SkinCeuticals A.G.E. (Advanced Glycation End-products) line is specifically designed to address the structural skin changes that lead to sagging and volume loss—making it ideal for those experiencing Ozempic face. These products work by targeting glycation, a process that accelerates during metabolic changes such as rapid weight loss.

AGEs form when proteins or fats combine with sugars, resulting in a loss of skin stiffness and elasticity. Weight loss-induced metabolic changes can increase AGE formation, accelerating visible signs of aging.

SkinCeuticals A.G.E. Interrupter Ultra Serum

This potent serum features upgraded concentrations of Proxylane, wild fruit flavonoids and niacinamide to combat multiple signs of aging simultaneously. Plus, its lightweight texture layers easily with other products.

What’s more, it’s particularly effective at improving skin texture and radiance—qualities that diminish during rapid weight loss. For best results, apply morning and night before your moisturizer for enhanced firmness and visible lifting effects.

SkinCeuticals A.G.E. Advanced Eye

The eye area often shows signs of Ozempic face first. This specialized treatment combines Proxylane, blueberry extract and flavonoids to target visible signs of aging around the eyes.

Its formula provides immediate brightening while improving firmness and reducing dark circles over time. All you have to do is gently pat this cream around your orbital bone morning and night.

SkinCeuticals A.G.E. Interrupter Advanced Corrective Cream

Formulated with 18% concentrated proxylane, wild fruit flavonoid blend and glycyrrhetinic acid, this cream improves the appearance of fine lines, wrinkles and skin texture.

Clinical studies demonstrate visible improvements in multiple wrinkle zones and increased firmness after twelve weeks. To experience the benefits for yourself, simply apply twice daily.

Complementary SkinCeuticals products for complete support

While the A.G.E. collection targets volume loss directly, these additional products provide essential support for overall skin health during your GLP-1 journey.

SkinCeuticals C E Ferulic Antioxidant Serum

This award-winning serum is your first line of defense. During rapid physiological changes, your skin experiences increased oxidative stress, which accelerates the aging process. This powerful combination of 15% vitamin C, 1% vitamin E and 0.5% ferulic acid neutralizes free radicals before they damage your skin's support structure.

Vitamin C is essential for collagen synthesis—the foundation your skin needs to maintain firmness during weight loss.

SkinCeuticals HA Intensifier Multi-Glycan Multi-Dimensional Volumizing Serum

This innovative serum increases your skin's natural hyaluronic acid production by up to 30%, helping your skin create its own rather than simply applying it topically. The multi-glycan technology supports your skin's natural filler mechanisms, providing a cushioning effect that counteracts hollowness. Clinical studies show visible improvements in skin fullness within eight weeks.

SkinCeuticals Retinol 1.0 Maximum Strength Refining Night Cream

This maximum-strength formula contains 1.0% pure retinol to stimulate cell turnover and boost collagen production while you sleep. As you lose facial fat, maintaining robust collagen levels helps prevent the skin from appearing crepey or saggy.

SkinCeuticals Physical Fusion UV Defense Tinted Mineral Sunscreen SPF 50

Daily sun protection is critical when your skin is vulnerable. This 100% mineral sunscreen offers broad-spectrum UVA/UVB protection with a universal tint that complements your natural skin tone.

Its formula contains artemia salina to boost the skin's resistance to UV and heat stress. With 6% titanium dioxide and 5% zinc oxide, this sunscreen provides physical protection without a white cast.

Beyond topical products

While skin care forms an approach to Ozempic face, there are also some lifestyle adjustments you can make to set yourself up for success:

Stay hydrated: Adequate water intake supports skin plumpness. Aim for at least eight glasses daily.

Prioritize protein: Protein contributes to the creation of new, healthy collagen, so it’s important to maintain a diet that meets your recommended daily intake. 

Consider professional treatments: Combining your SkinCeuticals routine with in-office procedures like laser, biostimulators and filler can enhance results.

Your path forward

Understanding what causes Ozempic face and learning how to avoid Ozempic face empowers you to maintain both your weight loss success and improve your appearance throughout. These seven SkinCeuticals products provide a scientifically backed approach to supporting your skin through this transformative period.

Your weight loss journey represents a significant commitment to your health. Your skin care routine should reflect that same dedication. With the right products and consistent application, you can achieve the healthy, vibrant appearance that matches how incredible you feel.

Looking for more ways to boost firmness and radiance with SkinCeuticals? You can read more on the LovelySkin Blog!