Return to Product Details
SkinMedica TNS® Advanced+ Serum

Reviews For SkinMedica TNS® Advanced+ Serum

$221.25 was $295.00
1,879 Reviews
October 27, 2025

Well Worth The Money

I had been hearing really great things about this serum for a while now but I have always gone back and forth about purchasing it due to the cost. I finally went ahead and purchased this serum and I must say I am beyond impressed. Now that I am in my early 50's I was looking for a serum for more mature skin. The serum actually consists of two formulations that are dispensed via a dual chamber system; chamber 1 includes TNS-MR and chamber 2 consists of Renessensce (RSC) Advanced. After doing some research on this product, I learned that Growth factors are messenger proteins that are inherent in our bodies and are capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Growth factors play an important role in maintaining healthy skin, and topical application may help improve the appearance of fine lines, wrinkles, skin tone and texture. Progeline works by helping your skin to repair itself and therefore prevent signs of aging. I finally decided to move forward after reading about the science behind this product and I must say I am glad I purchased this serum. After only a few uses I can definitely see a difference in terms of elasticity and epidermis thickness. I really wasn't expecting to see such results so quickly but what a difference this serum has made thus far. Is it worth the price? I suppose that is subjective; however, I believe this serum is well worth the cost; so much so, I set my account up to auto replenish this serum every 6 weeks. I think this serum is best for those with mature skin looking for a product that will improve the overall appearance of wrinkles, fine lines, skin tone, and texture. If you are like me and have been on the fence about purchasing this serum due to it's cost, I strongly recommend purchasing this serum if you are looking to up your skin care routine with a powerful anti-aging serum. Well worth the money and them some if you want to take a few years off your face without surgery.

Profile Photo

LovelySkin Customer

from Nevada

Age Group: 50-59

Verified Purchase

1 person found this helpful

October 22, 2025

Results not enough for the expense

I wanted to love this product. I believe that it does its job but for me it was just too subtle to justify the cost of continuing to purchase.

Profile Photo

LovelySkin Customer

from Iowa

Age Group: 50-59

Verified Purchase

3 people found this helpful

October 15, 2025

Love the results not the bottle

Fantastic product that has kept my skin looking young and glowing for years. I don’t look 65 and I love it. The pump on the bottle gives me issues with not evenly dispensing. I love it enough to stick with it while hoping for a redesign!

Profile Photo

LookingYoungPA

Age Group: 60-69

Straight, Color treated hair

Combination Skin

Verified Purchase

7 people found this helpful

October 10, 2025

Still too early to tell

I think it might be too early to tell. but theres something about this serum that i think makes my skin look and feel amazing. Ill definitely be repurchasing.

Profile Photo

Kg16

from Puerto Rico

Age Group: 30-39

Dry Skin

Verified Purchase

1 person found this helpful

October 10, 2025

Great Product

I have used this product consistently for over 20 years. I am 63 and told that I look great!

Profile Photo

LovelySkin Customer

from Kansas

Verified Purchase

0 people found this helpful

September 27, 2025

Great face product

I’ve been using this cream for about five years, continuously get comments about how great my skin looks. I always have a back up bottle on hand. one thing about the product. I’m not happy with it’s impossible to see how much product is left in the bottle.

Profile Photo

Peg77

Age Group: 70-79

Wavy Hair

Verified Purchase

3 people found this helpful

September 27, 2025

Skinmedica TNS

Excellent serum. Almost immediate results. Makes my skin smooth,clear and bright. I just don’t like the price tag.

Profile Photo

LovelySkin Customer

from New Jersey

Age Group: 50-59

Straight Hair

Mature Skin

Verified Purchase

4 people found this helpful

September 27, 2025

Actually works

I have been using this product for several years. This is one of the very few products that actually works and justifies the price tag. Highly recommended.

Profile Photo

LovelySkin Customer

Verified Purchase

1 person found this helpful

September 26, 2025

Amazing, Going to buy again!

This is what my dermatologist told me to start using. I love this stuff!!

Profile Photo

TaylorLM

from Texas

Age Group: 30-39

Straight, Dry Hair

Combination Skin

Verified Purchase

1 person found this helpful

September 25, 2025

Skin medica TNS serum

I love this serum especially after any type of face treatment. Wonderful post any laser treatment. Highly recommend this

Profile Photo

LovelySkin Customer

from California

Age Group: 60-69

Mature Skin

Verified Purchase

1 person found this helpful

September 25, 2025

Holy grail

I have used this product on and off for years as a special treat when the finances allow. I finally took the plunge to do auto replenishment to see if continual use will make a difference. So far so good and I am loving this product even more now. The first few pumps did not distribute the product evenly as the other chamber didn’t come out and after I do some research, this is unknown issue. Would be nice if they could come up with a better option for packaging as this is a very pricey product and every pump counts

Profile Photo

LovelySkin Customer

from Virginia

Age Group: 40-49

Verified Purchase

6 people found this helpful

September 25, 2025

TNS

I’ve been using TNS for months and I feel like my skin texture or something is better. It’s pricey but I’m hoping in the long run it will be well worth it.

Profile Photo

LovelySkin Customer

from California

Verified Purchase

1 person found this helpful

September 25, 2025

SkinMedica TNS Advanced+ Serum

Over 50 , sensitive/reactive skin. This serum has improved my texture, lightened dark spots, hydrating. It’s a game changer! Noticeable improvement with in a week.

Profile Photo

LovelySkin Customer

from North Carolina

Age Group: 50-59

Verified Purchase

2 people found this helpful

September 24, 2025

Wish I didn't love it!

This serum is quite pricey and I really hoped I wouldn't think it was worth it. But, as the saying goes, "you get what you pay for." It really has made a significant difference with my skin quality and I have purchased it numerous times. I really feel my skin quality is much better with it than without it.

Profile Photo

momincharge

from Connecticut

Age Group: 60-69

Mature Skin

Verified Purchase

2 people found this helpful

September 24, 2025

Not sure

Overall, I like the texture and how the formulation is packaged separately in 2 portions that are merged together when you pump it. I feel like that will keep the serum potent longer. I don't know if I see any real changes in my face yet, so I am still waiting. But I don't think it is giving me breakouts and I have very sensitive skin. I think the conditioned media component has a lot of quality skin enhancing ingredients, so I believe it is a good product and will keep using it for now.

Profile Photo

LovelySkin Customer

from Massachusetts

Age Group: 30-39

Straight Hair

Combination Skin

Verified Purchase

1 person found this helpful

September 18, 2025

Love this product

My skin is soft and revitalized. Can’t live without it.

Profile Photo

DKFlorida

from Florida

Age Group: 60-69

Straight, Color treated hair

Dry Skin

Verified Purchase

0 people found this helpful

September 13, 2025

MVP

My skin feels very hydrated and looks so glowy after this I don’t even need moisturizer. Ppl in the industry say this is a must have so I won’t live without it

Profile Photo

LovelySkin Customer

from New Jersey

Age Group: 40-49

Straight hair, Damage & split ends

Oily Skin

Verified Purchase

1 person found this helpful

September 12, 2025

Wonderful improvement

I’m on my second pump bottle of the TNS Advanced + Serum. I can really tell a difference in the appearance of my skin. I use it morning and night. My skin tone is much more even. Less red and more moisturized. There has been a decrease in all of the fine lines on my face. This is an expensive serum, but it seems to work for me.

Profile Photo

OlyLady

from Washington

Age Group: 70-79

Verified Purchase

0 people found this helpful

September 11, 2025

Top Serum to improve skin texture

I've tried multiple serums to reduce lines/wrinkles and improve the texture of my skin, this is my hands down favorite. It is lightweight and fragrance free and does the best job of improving the texture of my skin, reducing fine lines and making my skin look and feel firmer.

Profile Photo

ElizaS

from Florida

Age Group: 60-69

Verified Purchase

0 people found this helpful

September 09, 2025

younger brighter skin

I have been using TNS advanced serum for 7 years Light weight serum that has reduced my fine lines and kept them away. A day doesn't go by that someone doesn't make a comment about how wonderful my skin looks.

Profile Photo

LovelySkin Customer

from Georgia

Verified Purchase

2 people found this helpful


Loading
Return to the top